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Results for “Resistance to Immunotherapy”

77 trials

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Showing 20 of 77 results

Early research (Phase 1)Study completedNCT03629756
What this trial is testing

Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Who this might be right for
Non-small Cell Lung CancerSquamous Cell Carcinoma of the Head and NeckBreast Cancer+9 more
Arcus Biosciences, Inc. 48
Testing effectiveness (Phase 2)Looking for participantsNCT05824975
What this trial is testing

Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

Who this might be right for
Advanced Solid TumorMetastatic Solid TumorSoft Tissue Sarcoma (STS)+6 more
GI Innovation, Inc. 358
Early research (Phase 1)Ended earlyNCT04615845
What this trial is testing

Autologous Dendritic Cell Immunotherapy in Patients With mCRPC

Who this might be right for
Metastatic Castration Resistant Prostate Cancer
Pharmicell Co., Ltd. 3
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07014215
What this trial is testing

PD-1 Combined With Bevacizumab and PCSK-9 Inhibitor in Patients With Advanced NSCLC Who Have Progressed After Anti- PD- 1/L1 Therapy

Who this might be right for
NSCLC (Advanced Non-small Cell Lung Cancer)Resistance to Immunotherapy
Anhui Provincial Cancer Hospital 52
Early research (Phase 1)Not Yet RecruitingNCT05662904
What this trial is testing

Genetic Ablation of CD33 in HSC to Broaden the Therapeutic Index of CD33-directed Immunotherapy in Patients with AML

Who this might be right for
Relapsed/Refractory Acute Myeloid Leukemia (AML)
German Cancer Research Center 12
Early research (Phase 1)Study completedNCT03835533
What this trial is testing

Platform Study for Prostate Researching Translational Endpoints Correlated to Response to Inform Use of Novel Combinations

Who this might be right for
Metastatic Castration-resistant Prostate Cancer
Parker Institute for Cancer Immunotherapy 43
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07324473
What this trial is testing

Ivarmacitinib Combined With Camrelizumab and Apatinib for Unresectable Advanced Hepatocellular Carcinoma With Acquired Resistance to Immune Checkpoint Therapy: A Single-Arm Exploratory Clinical Study

Who this might be right for
Hepatocellular CarcinomasResistance to ImmunotherapyImmunomodulation+1 more
First Affiliated Hospital of Chongqing Medical University 65
Early research (Phase 1)Looking for participantsNCT07813637
What this trial is testing

Phase 1 Trial to Study JANX013 and JANX007 Combination in mCRPC

Who this might be right for
Prostate CancerCastration-Resistant Prostate Cancer (CRPC)Metastatic Prostate Cancer+1 more
Janux Therapeutics 110
Testing effectiveness (Phase 2)Study completedNCT03262779
What this trial is testing

Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer.

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Yale University 20
Early research (Phase 1)Study completedNCT06681402
What this trial is testing

Phase I Single-blind Clinical Trial to Evaluate the Safety and Local Immune Activation of a Toll-like Receptor 5 Agonist (FLAMOD) Administered by Aerosol

Who this might be right for
Pneumonia
Institut National de la Santé Et de la Recherche Médicale, France 46
Testing effectiveness (Phase 2)Looking for participantsNCT07639138
What this trial is testing

Lenalidomide Plus Targeted Therapy and Immunotherapy for Refractory HCC

Who this might be right for
Hepatocellular Carcinoma (HCC)
Shunda Du 32
Large-scale testing (Phase 3)Not Yet RecruitingNCT07437287
What this trial is testing

Testing Mitazalimab in Combination With Standard Chemotherapy in Immunotherapy Resistant Advanced Biliary Tract Cancers

Who this might be right for
Biliary Tract Cancer (BTC)
UNICANCER 160
Large-scale testing (Phase 3)Looking for participantsNCT05281471
What this trial is testing

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Who this might be right for
Platinum-resistant Ovarian CancerPlatinum-refractory Ovarian CancerFallopian Tube Cancer+4 more
Genelux Corporation 186
Testing effectiveness (Phase 2)Ended earlyNCT01420965
What this trial is testing

Sipuleucel-T, CT-011, and Cyclophosphamide for Advanced Prostate Cancer

Who this might be right for
Prostatic Neoplasms
Augusta University 7
Not applicableStudy completedNCT03985696
What this trial is testing

Exosomes and Immunotherapy in Non-Hodgkin B-cell Lymphomas

Who this might be right for
Lymphoma, B-cell, Aggressive Non-Hodgkin (B-NHL)
University Hospital, Limoges 90
Testing effectiveness (Phase 2)Active Not RecruitingNCT03607890
What this trial is testing

Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor

Who this might be right for
Refractory MSI - H Solid Tumors Prior of PD-(L) 1 TherapyMSI-H Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 38
Testing effectiveness (Phase 2)Active Not RecruitingNCT05873244
What this trial is testing

CXD101 in Immunotherapy-related Liver Cancer

Who this might be right for
HCC
Stephen Chan Lam 26
Testing effectiveness (Phase 2)Looking for participantsNCT07071103
What this trial is testing

Intestinal Low Dose Radiotherapy Combined With Immunotherapy in Immune-resistant Metastatic Malignant Solid Tumors

Who this might be right for
RadiotherapyMetastatic Solid CancersImmune Checkpoint Blockade+3 more
Chuangzhen Chen 48
Very early researchNot Yet RecruitingNCT06364800
What this trial is testing

Allogeneic Gamma-delta T Cells Combined With Targeted Therapy and Immunotherapy in a Phase 1 Clinical Trial of Hepatocellular Carcinoma Resistant to PD-1 Monoclonal Antibody

Who this might be right for
Hepatocellular Carcinoma
Beijing 302 Hospital 18
Not applicableStudy completedNCT04145141
What this trial is testing

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

Who this might be right for
Hepatocellular CarcinomaLiver CancerCholangiocarcinoma
National Cancer Institute (NCI) 132
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