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Results for “Resistance to Immunotherapy”

75 trials

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Showing 20 of 75 results

Large-scale testing (Phase 3)Not Yet RecruitingNCT07437287
What this trial is testing

Testing Mitazalimab in Combination With Standard Chemotherapy in Immunotherapy Resistant Advanced Biliary Tract Cancers

Who this might be right for
Biliary Tract Cancer (BTC)
UNICANCER 160
Early research (Phase 1)Looking for participantsNCT06469281
What this trial is testing

Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

Who this might be right for
Epithelial Ovarian CancerPrimary Peritoneal CarcinomaFallopian Tube Cancer
Regeneron Pharmaceuticals 90
Testing effectiveness (Phase 2)Looking for participantsNCT06035224
What this trial is testing

Cadonilimab（AK104） Plus Lenvatinib in Previous Immunotherapy Treated Advanced/Metastatic Clear Cell Renal Cell Carcinoma

Who this might be right for
Clear Cell Renal Cell Carcinoma、Resistance to Immunotherapy
RenJi Hospital 28
Testing effectiveness (Phase 2)Looking for participantsNCT05690048
What this trial is testing

Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)

Who this might be right for
ImmunotherapyHCC - Hepatocellular Carcinoma
Michael Dill 48
Testing effectiveness (Phase 2)Looking for participantsNCT06490068
What this trial is testing

Study of LTC004 Combine With Toripalimab in Patient With Solid Tumors Resistant to Immunotherapy

Who this might be right for
Advanced Solid Tumor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 10
Testing effectiveness (Phase 2)UnknownNCT00856804
What this trial is testing

Thalidomide Plus Peginterferon and Ribavirin in Patients With Interferon Resistance

Who this might be right for
Hepatitis C
Valme University Hospital 10
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07022301
What this trial is testing

Sintilimab Plus Anlotinib as Second or Further-line Therapy for ES-SCLC Who Have Progressed After Anti-PD-1/L1 Therapy

Who this might be right for
Small Cell Lung Cancer Extensive StageResistance to Immunotherapy
First Affiliated Hospital of Wannan Medical College 25
Testing effectiveness (Phase 2)Looking for participantsNCT07288034
What this trial is testing

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Who this might be right for
Lung Non-Small Cell CarcinomaStage IIIB Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8
City of Hope Medical Center 535
Not applicableNot Yet RecruitingNCT07028866
What this trial is testing

Virus-associated Tumour Microenvironment: Characterisation and Immunological Mechanisms of Resistance to Anti-tumour Treatments

Who this might be right for
Lymphoma Cancer
Assistance Publique - Hôpitaux de Paris 254
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07324473
What this trial is testing

Ivarmacitinib Combined With Camrelizumab and Apatinib for Unresectable Advanced Hepatocellular Carcinoma With Acquired Resistance to Immune Checkpoint Therapy: A Single-Arm Exploratory Clinical Study

Who this might be right for
Hepatocellular CarcinomasResistance to ImmunotherapyImmunomodulation+1 more
First Affiliated Hospital of Chongqing Medical University 65
Large-scale testing (Phase 3)Looking for participantsNCT05281471
What this trial is testing

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Who this might be right for
Platinum-resistant Ovarian CancerPlatinum-refractory Ovarian CancerFallopian Tube Cancer+4 more
Genelux Corporation 186
Testing effectiveness (Phase 2)Active Not RecruitingNCT03607890
What this trial is testing

Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor

Who this might be right for
Refractory MSI - H Solid Tumors Prior of PD-(L) 1 TherapyMSI-H Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 38
Early research (Phase 1)WithdrawnNCT05807126
What this trial is testing

Testing the Addition of Immunotherapy With Hu5F9-G4 (Magrolimab) to the Usual PARP Inhibitor, Olaparib for Treatment of Metastatic or Recurrent Breast or Castrate-Resistant Prostate Cancer With BRCA Mutations

Who this might be right for
Anatomic Stage IV Breast Cancer AJCC v8Castration-Resistant Prostate CarcinomaStage IVB Prostate Cancer AJCC v8
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)Looking for participantsNCT07306624
What this trial is testing

Nelmastobart in Combination With Docetaxel in Non Small Cell Lung Cancer

Who this might be right for
Non Small Cell Lung Cancer
STCube, Inc. 62
Not applicableUnknownNCT03985696
What this trial is testing

Exosomes and Immunotherapy in Non-Hodgkin B-cell Lymphomas

Who this might be right for
Lymphoma, B-cell, Aggressive Non-Hodgkin (B-NHL)
University Hospital, Limoges 90
Testing effectiveness (Phase 2)Study completedNCT03262779
What this trial is testing

Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer.

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Yale University 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT05990543
What this trial is testing

Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer

Who this might be right for
Recurrent or Metastatic Colorectal Cancer
Korea University Anam Hospital 59
Early research (Phase 1)Looking for participantsNCT05806814
What this trial is testing

Sipuleucel-T Based Autologous Cellular Immunotherapy for Advanced Prostate Cancer

Who this might be right for
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
University of Oklahoma 13
Not applicableUnknownNCT04253080
What this trial is testing

Expression of IL4 Induced Gene 1 in Patients With Cutaneous Melanoma: Value in Prognosis and/or in Predictive Response to Immune Checkpoint Inhibitors

Who this might be right for
Cutaneous Melanoma
Assistance Publique - Hôpitaux de Paris 170
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07412262
What this trial is testing

A Prospective, Single-Arm, Multicenter, Phase II Clinical Study of Chidamide Combined With Ivonescimab in the Treatment of Advanced Non-Small Cell Lung Cancer With Acquired Resistance to Immunotherapy and High YAP Protein Expression

Who this might be right for
Non-Small Cell Lung Cancer
Guangdong Association of Clinical Trials 32
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