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Results for “Ribociclib”

163 trials

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Showing 20 of 163 results

Testing effectiveness (Phase 2)Study completedNCT03822468
What this trial is testing

Study of 2 Ribociclib Doses in Combination With Aromatase Inhibitors in Women With HR+, HER2- Advanced Breast Cancer

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 376
Early research (Phase 1)Active Not RecruitingNCT02608216
What this trial is testing

[18F]FLT PET/CT in Rb+ Metastatic Breast Cancer

Who this might be right for
Breast NeoplasmMetastatic Breast CancerRb+ Breast Cancer
University of Pennsylvania 20
Large-scale testing (Phase 3)Not Yet RecruitingNCT07391774
What this trial is testing

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

Who this might be right for
Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8Anatomic Stage IIIC Breast Cancer AJCC v8+2 more
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)UnknownNCT02985125
What this trial is testing

LEE011 Plus Everolimus in Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy

Who this might be right for
Metastatic Pancreatic Adenocarcinoma
Georgetown University 44
Post-approval studies (Phase 4)Ended earlyNCT04657679
What this trial is testing

Pharmacokinetics and Pharmacogenomics of Ribociclib in Race-based Cohorts

Who this might be right for
Breast Cancer
Georgetown University 21
Early research (Phase 1)Ended earlyNCT05429502
What this trial is testing

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Who this might be right for
Neuroblastoma
Novartis Pharmaceuticals 12
Not applicableLooking for participantsNCT06805812
What this trial is testing

Predicting clinicAL outcoMes During First-line CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With Advanced Hormone REceptor-poSitive HER2-negative Breast Cancer: the Retrospective-prospective Multicenter Italian PALMARES-2 Study

Who this might be right for
Breast AdenocarcinomaBreast Cancer Stage IVBreast Cancer, Metastatic+38 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 3,500
Early research (Phase 1)Looking for participantsNCT05508906
What this trial is testing

Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Who this might be right for
Metastatic Breast CancerER-positive Breast CancerHER2-negative Breast Cancer+2 more
Olema Pharmaceuticals, Inc. 190
Very early researchActive Not RecruitingNCT02933736
What this trial is testing

Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients

Who this might be right for
Glioblastoma MultiformeMeningioma
Nader Sanai 48
Early research (Phase 1)Study completedNCT02333370
What this trial is testing

A Phase Ib Dose Escalation Study of the Combination of LEE011 With Letrozole and Dose Expansion of LEE011 With Hormonal Therapy for the Treatment of Pre-(With Goserelin) and Postmenopausal Women With Hormone Receptor Positive, HER2-negative, Advanced Breast Cancer

Who this might be right for
Hormone Receptor Positive, HER2-negative, Advanced Breast Cancer
Novartis Pharmaceuticals 88
Testing effectiveness (Phase 2)Active Not RecruitingNCT03090165
What this trial is testing

Ribociclib and Bicalutamide in AR+ TNBC

Who this might be right for
Triple Negative Breast Cancer
Kari Wisinski 37
Early research (Phase 1)Study completedNCT03009201
What this trial is testing

Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery

Who this might be right for
Advanced Soft Tissue SarcomaLocally Advanced AngiosarcomaLocally Advanced Leiomyosarcoma+24 more
OHSU Knight Cancer Institute 16
Testing effectiveness (Phase 2)Looking for participantsNCT05768139
What this trial is testing

First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Who this might be right for
Breast CancerSolid Tumors, Adult
Eli Lilly and Company 720
Not applicableStudy completedNCT07148505
What this trial is testing

Real-world Outcomes Among Patients Treated With Ribociclib

Who this might be right for
Metastatic Breast Cancer
Novartis Pharmaceuticals 373
Early research (Phase 1)Study completedNCT01237236
What this trial is testing

A Trial of LEE011 in Patients With Advanced Solid Tumors or Lymphoma.

Who this might be right for
Advanced Solid TumorLymphomas
Novartis Pharmaceuticals 156
Testing effectiveness (Phase 2)Study completedNCT03484923
What this trial is testing

Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

Who this might be right for
Melanoma
Novartis Pharmaceuticals 196
Early research (Phase 1)WithdrawnNCT04585724
What this trial is testing

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Who this might be right for
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more
Emory University
Early research (Phase 1)Study completedNCT02154776
What this trial is testing

Dose Escalation Study of LEE011 in Combination With Buparlisib and Letrozole in HR+, HER2-negative Post-menopausal Women With Advanced Breast Cancer.

Who this might be right for
Advanced or Metastatic Breast Cancer
Novartis Pharmaceuticals 13
Testing effectiveness (Phase 2)Ended earlyNCT01777776
What this trial is testing

Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma.

Who this might be right for
Locally Advanced Metastatic BRAF Mutant Melanoma
Array BioPharma 28
Early research (Phase 1)Ended earlyNCT03294694
What this trial is testing

Ribociclib + PDR001 in Breast Cancer and Ovarian Cancer

Who this might be right for
Metastatic Hormone-Receptor-Positive (HR+) Breast CancerHER2-Negative Breast CancerMetastatic Epithelial Ovarian Cancer
Dana-Farber Cancer Institute 33
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