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Results for “Richter's Syndrome”

88 trials

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Showing 20 of 88 results

Testing effectiveness (Phase 2)Looking for participantsNCT04271956
What this trial is testing

Efficacy and Safety of Zanubrutinib Plus Tislelizumab Treatment With or Without Sonrotoclax for Patients With Richter Transformation

Who this might be right for
Richter Transformation
German CLL Study Group 83
Testing effectiveness (Phase 2)Active Not RecruitingNCT05025800
What this trial is testing

ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma

Who this might be right for
Aggressive B-Cell Non-Hodgkin LymphomaAnn Arbor Stage III Grade 2 Follicular LymphomaAnn Arbor Stage III Grade 3 Follicular Lymphoma+17 more
M.D. Anderson Cancer Center 47
Testing effectiveness (Phase 2)Study completedNCT02530515
What this trial is testing

Ex Vivo-activated Autologous Lymph Node Lymphocytes in Treating Patients With Chronic Lymphocytic Leukemia

Who this might be right for
AnemiaCancer FatigueChronic Lymphocytic Leukemia+11 more
M.D. Anderson Cancer Center 8
Testing effectiveness (Phase 2)Study completedNCT02332980
What this trial is testing

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

Who this might be right for
Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue+20 more
Mayo Clinic 65
Testing effectiveness (Phase 2)Study completedNCT00452374
What this trial is testing

Oxaliplatin, Fludarabine, Cytarabine and Rituximab in Richter's Syndrome, Refractory CLL and PLL

Who this might be right for
Leukemia
M.D. Anderson Cancer Center 48
Testing effectiveness (Phase 2)Active Not RecruitingNCT02029443
What this trial is testing

ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaRichter's Syndrome+1 more
Acerta Pharma BV 306
Testing effectiveness (Phase 2)WithdrawnNCT06247540
What this trial is testing

Venetoclax, Rituximab and Nivolumab in Combination for the Treatment of Richter's Transformation Arising From Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Who this might be right for
Recurrent Transformed Chronic Lymphocytic LeukemiaRefractory Transformed Chronic Lymphocytic LeukemiaRichter Syndrome+2 more
Northwestern University
Testing effectiveness (Phase 2)Ended earlyNCT04305444
What this trial is testing

Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas

Who this might be right for
Relapsed Chronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic LeukemiaDiffuse Large B Cell Lymphoma+2 more
Zhejiang DTRM Biopharma 55
Early research (Phase 1)Looking for participantsNCT06735664
What this trial is testing

Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation

Who this might be right for
Recurrent Transformed Chronic Lymphocytic LeukemiaRefractory Transformed Chronic Lymphocytic LeukemiaRichter Syndrome+1 more
City of Hope Medical Center 23
Testing effectiveness (Phase 2)Ended earlyNCT01629511
What this trial is testing

Allogeneic Stem Cell Transplant for CLL

Who this might be right for
Allogeneic Hematopoietic Stem Cell Transplantation RecipientChronic Lymphocytic LeukemiaProlymphocytic Leukemia+1 more
M.D. Anderson Cancer Center 15
Not applicableNot Yet RecruitingNCT05923502
What this trial is testing

(CHANT)Real World Study of Duvelisib in the Treatment of Non-Hodgkin's Lymphoma (NHL)

Who this might be right for
Follicular LymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRichter Syndrome+3 more
Ruijin Hospital 200
Early research (Phase 1)Not Yet RecruitingNCT07539688
What this trial is testing

Phase I Clinical Study on the Safety and Efficacy of CY-219 CAR-T Cell Injection in the Treatment of Relapsed/Refractory B-Cell Lymphoma

Who this might be right for
Relapsed/Refractory B-cell LymphomaDiffuse Large B-cell LymphomaInert B-cell Lymphoma Transformed Into Large B-cell Lymphoma (Excluding Richter Transformation, THRLBCL, and BL)
Institute of Hematology & Blood Diseases Hospital, China 18
Early research (Phase 1)Ended earlyNCT03778073
What this trial is testing

Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma

Who this might be right for
B-cell Non Hodgkin LymphomaRichter's Transformation
TG Therapeutics, Inc. 18
Early research (Phase 1)Ended earlyNCT04978779
What this trial is testing

Evaluate VIP152 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia or Richter Syndrome

Who this might be right for
Relapsed Non Hodgkin LymphomaChronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic Leukemia+4 more
Vincerx Pharma, Inc. 6
Testing effectiveness (Phase 2)Looking for participantsNCT05388006
What this trial is testing

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Who this might be right for
Chronic Lymphocytic LeukemiaRichter SyndromeSmall Lymphocytic Lymphoma
Mayo Clinic 27
Testing effectiveness (Phase 2)WithdrawnNCT02718755
What this trial is testing

Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies

Who this might be right for
Hematologic Malignancy
M.D. Anderson Cancer Center
Testing effectiveness (Phase 2)WithdrawnNCT04660045
What this trial is testing

Early Intervention With Acalabrutinib in Patients With High Risk CLL

Who this might be right for
Chronic Lymphocytic LeukemiaCLL/SLL
Weill Medical College of Cornell University
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07735533
What this trial is testing

UB-VV400 With Rapamycin in Relapsed/Refractory B-cell Malignancies

Who this might be right for
Lymphoma, B CellLymphoma Non-HodgkinHigh Grade B Cell Lymphoma+4 more
Umoja Biopharma 274
Not applicableLooking for participantsNCT02863692
What this trial is testing

Registry of the German CLL Study Group

Who this might be right for
CLLSLLHCL+5 more
German CLL Study Group 8,000
Testing effectiveness (Phase 2)Active Not RecruitingNCT03162536
What this trial is testing

Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

Who this might be right for
Lymphoma, B-CellSmall Lymphocytic LymphomaChronic Lymphocytic Leukemia+6 more
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) 190
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