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Results for “Severe Liver Impairment”

64 trials

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Showing 20 of 64 results

Large-scale testing (Phase 3)Study completedNCT04119843
What this trial is testing

Safety and Diagnostic Efficacy of Mangoral in Participants With Focal Liver Lesions and Reduced Kidney Function

Who this might be right for
Known or Suspected Focal Liver LesionsSevere Renal Impairment
Ascelia Pharma AB 87
Early research (Phase 1)Study completedNCT03681457
What this trial is testing

Evaluation of the Pharmacokinetics of Tropifexor in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Healthy Control Subjects

Who this might be right for
Non-alcoholic Fatty Liver Disease
Novartis Pharmaceuticals 42
Early research (Phase 1)Study completedNCT05116826
What this trial is testing

Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients

Who this might be right for
Moderate Hepatic ImpairmentSevere Hepatic ImpairmentLiver Diseases
Genfit 25
Not applicableLooking for participantsNCT05399745
What this trial is testing

BILACO Trial: Biliary Atresia - a Severe Complex Congenital Liver Disease

Who this might be right for
Biliary AtresiaCognitive Impairment
Rigshospitalet, Denmark 100
Early research (Phase 1)Study completedNCT04634149
What this trial is testing

Evaluate the Drug Levels, Safety, and Tolerability of BMS-986036 in Participants With Normal Liver Function and Participants With Moderate and Severe Liver Impairment

Who this might be right for
Moderate Liver ImpairmentSevere Liver Impairment
Bristol-Myers Squibb 16
Early research (Phase 1)Study completedNCT02402452
What this trial is testing

Pharmacokinetics of Voxilaprevir in Adults With Normal Renal Function and Severe Renal Impairment

Who this might be right for
HCV Infection
Gilead Sciences 20
Early research (Phase 1)Looking for participantsNCT07168356
What this trial is testing

Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease

Who this might be right for
Hepatitis B
GlaxoSmithKline 32
Early research (Phase 1)Ended earlyNCT03295266
What this trial is testing

Single-Dose Pharmacokinetics of MK-3866 in Participants With Hepatic Impairment (MK-3866-006)

Who this might be right for
Hepatic InsufficiencyAntibacterial Agents
Merck Sharp & Dohme LLC 9
Early research (Phase 1)Study completedNCT00698464
What this trial is testing

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Who this might be right for
Hepatic CirrhosisAlcoholism
Novartis Pharmaceuticals 34
Early research (Phase 1)Study completedNCT02002767
What this trial is testing

Study to Evaluate the Pharmacokinetics of Velpatasvir in Participants With Normal Renal Function and Severe Renal Impairment

Who this might be right for
Hepatitis C Virus
Gilead Sciences 19
Early research (Phase 1)Study completedNCT04867941
What this trial is testing

Evaluate the Effect of Hepatic Insufficiency on the Pharmacokinetics (PK) of ACP-196

Who this might be right for
Hepatic Insufficiency
Acerta Pharma BV 18
Early research (Phase 1)Study completedNCT03814005
What this trial is testing

Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, ChronicLeukemia, Myeloid, Acute+3 more
Takeda 17
Early research (Phase 1)Study completedNCT03376841
What this trial is testing

Impact of Severe Hepatic Impairment on Pharmacokinetics of Cenicriviroc and Its Metabolites

Who this might be right for
Hepatic Impairment
Allergan 16
Not applicableStudy completedNCT02813538
What this trial is testing

Major Liver Resection: Early Clotting Disorders and Functional Impairment.

Who this might be right for
Hepatic InsufficiencyBlood Coagulation Disorders
Hospital General Universitario Gregorio Marañon 60
Early research (Phase 1)Study completedNCT03341884
What this trial is testing

Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants

Who this might be right for
Hepatic Insufficiency
Genentech, Inc. 29
Early research (Phase 1)Study completedNCT00903773
What this trial is testing

VX-950-TiDP24-C132: A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics of Telaprevir.

Who this might be right for
Hepatitis CKidney Diseases
Tibotec BVBA 24
Early research (Phase 1)Study completedNCT06812780
What this trial is testing

Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD2389

Who this might be right for
Hepatic Impairment
AstraZeneca 35
Early research (Phase 1)Study completedNCT05373953
What this trial is testing

Clinical Study to Investigate the Pharmacokinetics, Safety and Tolerability Following Single Administration of CHF6001 in Subjects With Mild, Moderate and Severe Liver Impairment in Comparison With Matched Healthy Control Subjects

Who this might be right for
Chronic Obstructive Pulmonary Disease
Chiesi Farmaceutici S.p.A. 44
Early research (Phase 1)Study completedNCT06425198
What this trial is testing

Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment

Who this might be right for
Hepatic ImpairmentHealthy Participants
Bristol-Myers Squibb 37
Not applicableNot Yet RecruitingNCT07151430
What this trial is testing

Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity

Who this might be right for
MultimorbidityHypertensionDiabetes Mellitus+8 more
Xuanwu Hospital, Beijing 358
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