Not applicableStudy completedNCT00505466What this trial is testingTransition From Research to Disclosure in Human GeneticsWho this might be right forEducation M.D. Anderson Cancer Center 577
Testing effectiveness (Phase 2)Study completedNCT03789175What this trial is testingNicotinamide Riboside on Mitochondrial Function in Li-Fraumeni SyndromeWho this might be right forCancerSkin FibroblastsMuscle Weakness National Heart, Lung, and Blood Institute (NHLBI) 1
Early research (Phase 1)Ended earlyNCT04477291What this trial is testingCG-806 in Patients With Relapsed or Refractory AML or Higher-Risk MDSWho this might be right forAcute Myeloid LeukemiaMyelodysplastic Syndromes Aptose Biosciences Inc. 45
Testing effectiveness (Phase 2)UnknownNCT04669067What this trial is testingTL-895 and KRT-232 Study in Acute Myeloid LeukemiaWho this might be right forAcute Myeloid Leukemia Telios Pharma, Inc. 18
Early research (Phase 1)Study completedNCT03434262What this trial is testingSJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain TumorsWho this might be right forAnaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more St. Jude Children's Research Hospital 68
Testing effectiveness (Phase 2)Ended earlyNCT03063203What this trial is testingSingle Agent Decitabine in TP53 Mutated Relapsed/Refractory Acute Myeloid LeukemiaWho this might be right forAcute Myeloid LeukemiaAcute Myeloid Leukemia, Relapsed, Adult Washington University School of Medicine 17
Early research (Phase 1)Looking for participantsNCT05631886What this trial is testingCombination of CAR-DC Vaccine and ICIs in Malignant TumorsWho this might be right forSolid Tumor, AdultLymphomaEphA2 Overexpression+4 more Chinese PLA General Hospital 10
Early research (Phase 1)Active Not RecruitingNCT07094464What this trial is testingMaintenance Therapy With Selinexor and Azacitidine in TP53 Mutant AML/MDS After TransplantationWho this might be right forTP53-mutated MDS and AMLAllogeneic Hematopoietic Stem Cell Transplantation Daihong Liu 20
Not applicableEnded earlyNCT03466034What this trial is testingThe Role of Hypoxia as a Selective Pressure for TP53 MutationsWho this might be right forEndometrial Cancer Institute of Cancer Research, United Kingdom 5
Not applicableLooking for participantsNCT01443468What this trial is testingClinical and Genetic Studies of Li-Fraumeni SyndromeWho this might be right forLi-Fraumeni SyndromeNeoplasmsTp53 Mutations National Cancer Institute (NCI) 5,000
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07372885What this trial is testingGRanulocyte Augmented Cord Blood Transplantation for Poor Risk leukaEmiaWho this might be right forAcute Myeloid LeukemiaStem Cell TransplantationStem Cell Transplantation, Hematopoietic+2 more University of Manchester 50
Testing effectiveness (Phase 2)Looking for participantsNCT04585750What this trial is testingThe Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)Who this might be right forAdvanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more PMV Pharmaceuticals, Inc 300
Large-scale testing (Phase 3)Study completedNCT01464086What this trial is testingLIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)Who this might be right forLi Fraumeni Syndrome Gustave Roussy, Cancer Campus, Grand Paris 107
Early research (Phase 1)Study completedNCT03654716What this trial is testingPhase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric CancerWho this might be right forLeukemiaBrain TumorSolid Tumor+1 more Dana-Farber Cancer Institute 21
Testing effectiveness (Phase 2)WithdrawnNCT04510584What this trial is testingMaintenance Treatment With Bevacizumab and Atezolizumab for Ovarian CancerWho this might be right forOvarian Endometrioid TumorFallopian Tube CancerPrimary Peritoneal Cancer+1 more University Health Network, Toronto
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06750991What this trial is testingCD-RCHOP in ND DLBCL With a Combination of TP53 Mutation and Del(17p)Who this might be right forDLBCL Ruijin Hospital 34
Testing effectiveness (Phase 2)Study completedNCT03931291What this trial is testingAPR-246 in Combination With Azacitidine for TP53 Mutated AML (Acute Myeloid Leukemia) or MDS (Myelodysplastic Syndromes) Following Allogeneic Stem Cell TransplantWho this might be right forAcute Myeloid Leukemia or Myelodysplastic Syndromes Aprea Therapeutics 33
Not applicableStudy completedNCT04452292What this trial is testingNext Generation Sequencing-Based Stratification of Front Line Treatment of HighGrade Neuroendocrine CarcinomaWho this might be right forLarge-Cell Neuroendocrine Carcinoma Charles Kunos 2
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05778149What this trial is testingSafety and Efficacy of Aumolertinib Combined With Anlotinib as 1st Line Treatment in Advanced Lung Cancer EGFR Mutation With TP53 Co-MutationWho this might be right forAumolertinibAnlotinibTP53+2 more Tianjin Medical University Cancer Institute and Hospital 47
Testing effectiveness (Phase 2)UnknownNCT04358393What this trial is testingAPG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDSWho this might be right forAMLAcute Myeloid LeukemiaChronic Myelomonocytic Leukemia+4 more Ascentage Pharma Group Inc. 69