Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “TP53 Mutation”

99 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 99 results

Testing effectiveness (Phase 2)WithdrawnNCT06690281
What this trial is testing

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

Who this might be right for
Gastrointestinal CarcinomaPancreatic CancerHepatocellular Cancer+5 more
National Cancer Institute (NCI)
Not applicableStudy completedNCT04452292
What this trial is testing

Next Generation Sequencing-Based Stratification of Front Line Treatment of HighGrade Neuroendocrine Carcinoma

Who this might be right for
Large-Cell Neuroendocrine Carcinoma
Charles Kunos 2
Testing effectiveness (Phase 2)Ended earlyNCT02688907
What this trial is testing

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation

Who this might be right for
Small Cell Lung Cancer
Samsung Medical Center 7
Early research (Phase 1)Not Yet RecruitingNCT07511062
What this trial is testing

Axatilimab Combined With Decitabine/Venetoclax for the Treatment of TP53-mutated AML

Who this might be right for
Acute Myeloid LeukemiaTP53 Gene Mutation
Northside Hospital, Inc. 32
Testing effectiveness (Phase 2)Active Not RecruitingNCT05491811
What this trial is testing

Ensartinib in Combination With Bevacizumab in ALK-positive NSCLC Patients With TP53 Mutation

Who this might be right for
Non-Small Cell Lung Cancer
Sun Yat-sen University 49
Not applicableUnknownNCT04489706
What this trial is testing

Arsenic Trioxide in Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation

Who this might be right for
Ovarian CancerEndometrial Cancer
Ruijin Hospital 20
Testing effectiveness (Phase 2)Study completedNCT02758665
What this trial is testing

Trial of Ibrutinib Plus Venetoclax Plus Obinutuzumab in Patients With CLL

Who this might be right for
Leukemia, Lymphocytic, Chronic
University of Ulm 41
Testing effectiveness (Phase 2)Ended earlyNCT03063203
What this trial is testing

Single Agent Decitabine in TP53 Mutated Relapsed/Refractory Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia, Relapsed, Adult
Washington University School of Medicine 17
Not applicableStudy completedNCT00505466
What this trial is testing

Transition From Research to Disclosure in Human Genetics

Who this might be right for
Education
M.D. Anderson Cancer Center 577
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Early research (Phase 1)Active Not RecruitingNCT05396859
What this trial is testing

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaRecurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia
OHSU Knight Cancer Institute 13
Testing effectiveness (Phase 2)WithdrawnNCT04510584
What this trial is testing

Maintenance Treatment With Bevacizumab and Atezolizumab for Ovarian Cancer

Who this might be right for
Ovarian Endometrioid TumorFallopian Tube CancerPrimary Peritoneal Cancer+1 more
University Health Network, Toronto
Testing effectiveness (Phase 2)Looking for participantsNCT06413992
What this trial is testing

Camrelizumab Plus Fluzoparib for TP-53 Mutated Endometrial Cancer

Who this might be right for
Endometrial CarcinomaTP53 MutationRecurrent or Metastatic
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 117
Testing effectiveness (Phase 2)Study completedNCT02337829
What this trial is testing

Acalabrutinib in Patients With Relapsed/Refractory and Treatment naïve Deletion 17p CLL/SLL

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Acerta Pharma BV 48
Testing effectiveness (Phase 2)UnknownNCT04869475
What this trial is testing

Arsenic Trioxide in Refractory Solid Tumors With Rescuable p53 Mutation

Who this might be right for
Refractory Solid Tumors
Ruijin Hospital 20
Testing effectiveness (Phase 2)Ended earlyNCT03149679
What this trial is testing

The p53 Colorectal Cancer Trial

Who this might be right for
Colorectal Cancer MetastaticColorectal Cancer Stage IVTP53 Gene Mutation
Haukeland University Hospital 12
Not applicableStudy completedNCT04976439
What this trial is testing

Patogenic Mutation in 5 Genes

Who this might be right for
Colorectal CancerAPC Gene MutationTP53 Gene Mutation+3 more
Dr Cipto Mangunkusumo General Hospital 22
Early research (Phase 1)Active Not RecruitingNCT07094464
What this trial is testing

Maintenance Therapy With Selinexor and Azacitidine in TP53 Mutant AML/MDS After Transplantation

Who this might be right for
TP53-mutated MDS and AMLAllogeneic Hematopoietic Stem Cell Transplantation
Daihong Liu 20
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Early research (Phase 1)Looking for participantsNCT06778863
What this trial is testing

CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorMetastatic Solid Tumor+8 more
Clasp Therapeutics, Inc. 90
Load More Results