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Results for “TP53 Mutation”

101 trials

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Showing 20 of 101 results

Early research (Phase 1)Study completedNCT06054464
What this trial is testing

Investigate the Effects of Acid Reducing Agents on Pharmacokinetics of PC14586 in Healthy Participants

Who this might be right for
Healthy Volunteers
PMV Pharmaceuticals, Inc 28
Not applicableNot Yet RecruitingNCT06900582
What this trial is testing

SENTInel Node Mapping Versus Comprehensive Lymphadenectomy in p53-Mutated Endometrial Cancer: A Non-Inferiority Randomized Trial

Who this might be right for
LymphadenectomyEndometrial CancerGene, p53+1 more
University Hospital, Strasbourg, France 374
Not applicableActive Not RecruitingNCT07303218
What this trial is testing

The HER Project: HRD in EGFR-mutated NSCLC

Who this might be right for
EGFRNon Small Cell Lung CancerHomologous Recombination Deficiency+1 more
IRCCS San Raffaele 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT02965950
What this trial is testing

The p53 Breast Cancer Trial

Who this might be right for
Locally Advanced Breast CancerMetastatic Breast Carcinoma
Haukeland University Hospital 190
Not applicableUnknownNCT03524677
What this trial is testing

Mutation of K-RAS, CDKN2A, SMAD4 and TP53 in Pancreatic Cancer: Role of Liquid Biopsy in Preoperative Diagnosis

Who this might be right for
Pancreatic Cancer
University of Roma La Sapienza 50
Testing effectiveness (Phase 2)Study completedNCT01164995
What this trial is testing

Study With Wee-1 Inhibitor AZD1775 (MK-1775) and Carboplatin to Treat p53 Mutated Refractory and Resistant Ovarian Cancer

Who this might be right for
Epithelial Ovarian Cancer
The Netherlands Cancer Institute 24
Not applicableStudy completedNCT02827617
What this trial is testing

Identification of Biomarkers That Are Predictive of Early Ibrutinib Treatment Failure in High Risk TP53 Mutated Chronic Lymphocytic Leukemia

Who this might be right for
Chronic Lymphocytic Leukemia
Oncology Institute of Southern Switzerland 56
Not applicableNot Yet RecruitingNCT06521684
What this trial is testing

Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma

Who this might be right for
Endometrial NeoplasmsTP53 Gene MutationChromosomal Instability+1 more
Peking Union Medical College Hospital 110
Testing effectiveness (Phase 2)UnknownNCT04533321
What this trial is testing

A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell Carcinoma

Who this might be right for
Squamous Cell Carcinoma
National University Hospital, Singapore 20
Large-scale testing (Phase 3)Study completedNCT02756611
What this trial is testing

Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)

Who this might be right for
Chronic Lymphocytic Leukemia
AbbVie 258
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05778149
What this trial is testing

Safety and Efficacy of Aumolertinib Combined With Anlotinib as 1st Line Treatment in Advanced Lung Cancer EGFR Mutation With TP53 Co-Mutation

Who this might be right for
AumolertinibAnlotinibTP53+2 more
Tianjin Medical University Cancer Institute and Hospital 47
Testing effectiveness (Phase 2)UnknownNCT03588078
What this trial is testing

Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine

Who this might be right for
Myelodysplastic Syndrome With Gene MutationAcute Myeloid Leukemia With Gene MutationsMyeloproliferative Neoplasm+1 more
Groupe Francophone des Myelodysplasies 53
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Large-scale testing (Phase 3)Study completedNCT04285567
What this trial is testing

Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine And Rituximab (BR) in FIT Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without DEL (17P) or TP53 Mutation

Who this might be right for
Chronic Lymphocytic Leukemia (CLL)
Hoffmann-La Roche 166
Early research (Phase 1)Looking for participantsNCT06908434
What this trial is testing

A Phase I First-in-Human Study of GenSci128 in Patients With Solid Tumors Harboring a TP53 Y220C Mutation

Who this might be right for
Solid Tumors Harboring a TP53 Y220C Mutation
Changchun GeneScience Pharmaceutical Co., Ltd. 82
Not applicableUnknownNCT03938012
What this trial is testing

Evaluating Mutations in MET and TP53 Among Patients Diagnosed With Squamous Cell Carcinoma

Who this might be right for
Squamous Cell Carcinoma of the LungSquamous Cell Carcinoma of the Head and Neck
National University Hospital, Singapore 80
Not applicableLooking for participantsNCT01443468
What this trial is testing

Clinical and Genetic Studies of Li-Fraumeni Syndrome

Who this might be right for
Li-Fraumeni SyndromeNeoplasmsTp53 Mutations
National Cancer Institute (NCI) 5,000
Testing effectiveness (Phase 2)Looking for participantsNCT07008638
What this trial is testing

Phase I/II Clinical Trial of Proteasome Inhibitor in Combination With CPX-351 for the Treatment of Newly-Diagnosed TP53-mutated Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid LeukemiaTP53
Masonic Cancer Center, University of Minnesota 32
Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
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