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Results for “Targeted Molecular Therapy”

155 trials

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Showing 20 of 155 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT04699188
What this trial is testing

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Who this might be right for
KRAS G12C Mutant Solid TumorsCarcinoma, Non-Small-Cell LungCarcinoma, Colorectal+7 more
Novartis Pharmaceuticals 344
Not applicableStudy completedNCT00897702
What this trial is testing

Molecular Mechanisms of Clinical Resistance to Targeted Therapy Among Patients With Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 269
Testing effectiveness (Phase 2)Study completedNCT02094872
What this trial is testing

Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic

Who this might be right for
Recurrent MelanomaStage IIIA MelanomaStage IIIB Melanoma+2 more
Yale University 49
Testing effectiveness (Phase 2)Looking for participantsNCT05332561
What this trial is testing

Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)

Who this might be right for
Early-stage Breast Cancer
German Cancer Research Center 240
Large-scale testing (Phase 3)Looking for participantsNCT06988475
What this trial is testing

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

Who this might be right for
Solid TumourHaematological MalignancyMalignant Neoplasm+8 more
Cancer Research UK 30
Not applicableUnknownNCT04331912
What this trial is testing

PFS and OS of Patients With Advanced Neuroendocrine Cancer (NEN) After Systemic Treatment

Who this might be right for
Neuroendocrine Tumors
University of Warmia and Mazury 100
Testing effectiveness (Phase 2)Looking for participantsNCT02925234
What this trial is testing

The Drug Rediscovery Protocol (DRUP Trial)

Who this might be right for
CancerTumorsNeoplasm+1 more
The Netherlands Cancer Institute 1,550
Not applicableStudy completedNCT06881433
What this trial is testing

Immune Checkpoint Inhibitors and Anti-vascular Endothelial Growth Factor Antibody/Tyrosine Kinase Inhibitors With or Without HAIC for Unresectable HCC With Portal Vein Tumor Thrombosis

Who this might be right for
Hepatocellular Carcinoma (HCC)
Zhongda Hospital 1,649
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06523049
What this trial is testing

Vorolanib Plus Sintilimab for Advanced Renal Cell Carcinoma After Failure of Prior Immune Checkpoint Inhibitors Based Combination Therapy

Who this might be right for
Renal Cell CarcinomaImmunotherapyMolecular Targeted Therapy
Hao Zeng 67
Not applicableStudy completedNCT06376773
What this trial is testing

Neoadjuvant Treatment Based on Gastric Cancer Molecular Subtyping.

Who this might be right for
Advanced Gastric CancerNeoadjuvant TherapyMulti-omics Analysis
Fujian Medical University 234
Very early researchEnded earlyNCT04592991
What this trial is testing

CCR2 AAA Pilot Study

Who this might be right for
Abdominal Aortic Aneurysm (AAA)
Washington University School of Medicine 1
Not applicableStudy completedNCT02613962
What this trial is testing

Proof -of -Concept Study To Stratify Targeted Therapies Adapted To Molecular Profiling

Who this might be right for
Relapsed or Refractory Pediatric Tumor
Gustave Roussy, Cancer Campus, Grand Paris 791
Not applicableLooking for participantsNCT05885009
What this trial is testing

Feasibility and Impact of Liquid Biopsy Genomic Profiling on Treatment Patients With Metastatic Prostate Cancer in Spain (SOLTI-2102)

Who this might be right for
Metastatic Prostate Cancer
SOLTI Breast Cancer Research Group 240
Very early researchNot Yet RecruitingNCT07280793
What this trial is testing

CAR-T Cell Efficacy With Molecular Imaging in Multiple Myeloma

Who this might be right for
Non-invasive CAR-T Cell MonitoringBCMA-targeted PET ImagingCAR-T Cell Biodistribution and Persistence+1 more
Xuzhou Medical University 10
Not applicableLooking for participantsNCT04504604
What this trial is testing

TCF-001 TRACK (Target Rare Cancer Knowledge) Study

Who this might be right for
Rare CancersCholangiocarcinomaCancer of Unknown Primary Site
TargetCancer Foundation 400
Large-scale testing (Phase 3)Not Yet RecruitingNCT07440290
What this trial is testing

DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

Who this might be right for
Haematological MalignancyMalignant NeoplasmLymphoproliferative Disorders+16 more
Cancer Research UK 30
Early research (Phase 1)Looking for participantsNCT06983743
What this trial is testing

ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors

Who this might be right for
Metastatic Solid Tumors
Erasca, Inc. 200
Post-approval studies (Phase 4)UnknownNCT05187208
What this trial is testing

PARP Inhibitor Oral Maintenance in Low-Risk Ovarian Cancer

Who this might be right for
Epithelial Ovarian CancerOvarian CancerOvarian Cancer Stage III+1 more
Seoul National University Hospital 102
Testing effectiveness (Phase 2)UnknownNCT04160416
What this trial is testing

MXELOXIRI Combined With Molecular Targeted Drug in mCRC

Who this might be right for
Unresectable Metastatic Colorectal Cancer
First Affiliated Hospital of Zhejiang University 48
Testing effectiveness (Phase 2)Study completedNCT04720131
What this trial is testing

Camrelizumab Combined With Apatinib and Capecitabine in Patients With Advanced Biliary Tract Cancer.

Who this might be right for
Biliary Tract CancerAnti-PD-1 TherapyTargeted Molecular Therapy+1 more
Beijing Friendship Hospital 28
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