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Results for “Tp53 Mutations”

92 trials

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Showing 20 of 92 results

Early research (Phase 1)UnknownNCT03645200
What this trial is testing

Treatment of Carrying TP53 Harmful Mutations

Who this might be right for
Advanced Cancer
Tianjin Medical University Second Hospital 60
Large-scale testing (Phase 3)Study completedNCT02756611
What this trial is testing

Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)

Who this might be right for
Chronic Lymphocytic Leukemia
AbbVie 258
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Testing effectiveness (Phase 2)Study completedNCT02448329
What this trial is testing

Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy

Who this might be right for
Advanced Gastric Adenocarcinoma
Samsung Medical Center 26
Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Testing effectiveness (Phase 2)UnknownNCT03381781
What this trial is testing

Decitabine,Cytarabine and Arsenic Trioxide for Acute Myeloid Leukemia With p53 Mutations

Who this might be right for
Acute Myeloid LeukemiaP53 Mutation
Li Junmin 100
Early research (Phase 1)Looking for participantsNCT06778863
What this trial is testing

CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorMetastatic Solid Tumor+8 more
Clasp Therapeutics, Inc. 90
Testing effectiveness (Phase 2)Active Not RecruitingNCT03611868
What this trial is testing

APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Who this might be right for
Unresectable or Metastatic Melanoma or Advanced Solid TumorsMelanomaUveal Melanoma+5 more
Ascentage Pharma Group Inc. 230
Large-scale testing (Phase 3)Active Not RecruitingNCT02066220
What this trial is testing

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

Who this might be right for
Brain Tumors
Universitätsklinikum Hamburg-Eppendorf 360
Not applicableStudy completedNCT02289326
What this trial is testing

Biomarker Monitoring in TP53 Mutation Carriers

Who this might be right for
Li-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation Carrier
Scripps Health 6
Not applicableNot Yet RecruitingNCT07632170
What this trial is testing

The Efficacy and Safety of Selinisole Combined With Azacitidine and Venetoclax in the Treatment of Newly Diagnosed High-risk Myeloid Tumors With TP53 Mutations

Who this might be right for
Myeloid Tumors
Bing Han 30
Large-scale testing (Phase 3)Looking for participantsNCT06043973
What this trial is testing

Almonertinib Combined With Anlotinib as First-line Treatment for Advanced Non-small Cell Lung Cance

Who this might be right for
Advanced Non-small Cell Lung Cancer
Qianfoshan Hospital 98
Early research (Phase 1)Study completedNCT01981525
What this trial is testing

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Who this might be right for
Li-Fraumeni Syndrome
National Cancer Institute (NCI) 26
Early research (Phase 1)Looking for participantsNCT06795009
What this trial is testing

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Who this might be right for
Uterine CancerEndometrial Cancer
Washington University School of Medicine 36
Testing effectiveness (Phase 2)Active Not RecruitingNCT05491811
What this trial is testing

Ensartinib in Combination With Bevacizumab in ALK-positive NSCLC Patients With TP53 Mutation

Who this might be right for
Non-Small Cell Lung Cancer
Sun Yat-sen University 47
Large-scale testing (Phase 3)Not Yet RecruitingNCT05489848
What this trial is testing

Chemotherapy vs Chemoradiotherapy for Post-operative Endometrial Cancer Patients With P53-mutation

Who this might be right for
Endometrial Cancer
Fudan University 294
Not applicableUnknownNCT03927599
What this trial is testing

Advanced Refractory Solid Tumors With TP53 Mutations Register Study

Who this might be right for
Solid Tumor, Adult
Tianjin Medical University Second Hospital 100
Large-scale testing (Phase 3)Looking for participantsNCT07342478
What this trial is testing

ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL

Who this might be right for
CLL / SLLCLL (Chronic Lymphocytic Leukemia)CLL, Refractory+5 more
Newave Pharmaceutical Inc 306
Not applicableUnknownNCT02140723
What this trial is testing

P53 and Response to Preoperative Radiotherapy for T2 and T3

Who this might be right for
Rectal Cancer
Medical University of Vienna 60
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