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Results for “Tp53 Mutations”

88 trials

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Showing 20 of 88 results

Early research (Phase 1)Study completedNCT06054464
What this trial is testing

Investigate the Effects of Acid Reducing Agents on Pharmacokinetics of PC14586 in Healthy Participants

Who this might be right for
Healthy Volunteers
PMV Pharmaceuticals, Inc 28
Not applicableNot Yet RecruitingNCT06900582
What this trial is testing

SENTInel Node Mapping Versus Comprehensive Lymphadenectomy in p53-Mutated Endometrial Cancer: A Non-Inferiority Randomized Trial

Who this might be right for
LymphadenectomyEndometrial CancerGene, p53+1 more
University Hospital, Strasbourg, France 374
Testing effectiveness (Phase 2)Active Not RecruitingNCT02965950
What this trial is testing

The p53 Breast Cancer Trial

Who this might be right for
Locally Advanced Breast CancerMetastatic Breast Carcinoma
Haukeland University Hospital 190
Not applicableUnknownNCT03524677
What this trial is testing

Mutation of K-RAS, CDKN2A, SMAD4 and TP53 in Pancreatic Cancer: Role of Liquid Biopsy in Preoperative Diagnosis

Who this might be right for
Pancreatic Cancer
University of Roma La Sapienza 50
Not applicableNot Yet RecruitingNCT06521684
What this trial is testing

Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma

Who this might be right for
Endometrial NeoplasmsTP53 Gene MutationChromosomal Instability+1 more
Peking Union Medical College Hospital 110
Testing effectiveness (Phase 2)UnknownNCT04533321
What this trial is testing

A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell Carcinoma

Who this might be right for
Squamous Cell Carcinoma
National University Hospital, Singapore 20
Large-scale testing (Phase 3)Study completedNCT02756611
What this trial is testing

Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)

Who this might be right for
Chronic Lymphocytic Leukemia
AbbVie 258
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05778149
What this trial is testing

Safety and Efficacy of Aumolertinib Combined With Anlotinib as 1st Line Treatment in Advanced Lung Cancer EGFR Mutation With TP53 Co-Mutation

Who this might be right for
AumolertinibAnlotinibTP53+2 more
Tianjin Medical University Cancer Institute and Hospital 47
Testing effectiveness (Phase 2)UnknownNCT03588078
What this trial is testing

Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine

Who this might be right for
Myelodysplastic Syndrome With Gene MutationAcute Myeloid Leukemia With Gene MutationsMyeloproliferative Neoplasm+1 more
Groupe Francophone des Myelodysplasies 53
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Large-scale testing (Phase 3)Study completedNCT04285567
What this trial is testing

Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine And Rituximab (BR) in FIT Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without DEL (17P) or TP53 Mutation

Who this might be right for
Chronic Lymphocytic Leukemia (CLL)
Hoffmann-La Roche 166
Early research (Phase 1)Looking for participantsNCT06908434
What this trial is testing

A Phase I First-in-Human Study of GenSci128 in Patients With Solid Tumors Harboring a TP53 Y220C Mutation

Who this might be right for
Solid Tumors Harboring a TP53 Y220C Mutation
Changchun GeneScience Pharmaceutical Co., Ltd. 82
Not applicableUnknownNCT03938012
What this trial is testing

Evaluating Mutations in MET and TP53 Among Patients Diagnosed With Squamous Cell Carcinoma

Who this might be right for
Squamous Cell Carcinoma of the LungSquamous Cell Carcinoma of the Head and Neck
National University Hospital, Singapore 80
Not applicableLooking for participantsNCT01443468
What this trial is testing

Clinical and Genetic Studies of Li-Fraumeni Syndrome

Who this might be right for
Li-Fraumeni SyndromeNeoplasmsTp53 Mutations
National Cancer Institute (NCI) 5,000
Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Testing effectiveness (Phase 2)Study completedNCT03789175
What this trial is testing

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

Who this might be right for
CancerSkin FibroblastsMuscle Weakness
National Heart, Lung, and Blood Institute (NHLBI) 1
Early research (Phase 1)Looking for participantsNCT06795009
What this trial is testing

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Who this might be right for
Uterine CancerEndometrial Cancer
Washington University School of Medicine 36
Not applicableUnknownNCT03927599
What this trial is testing

Advanced Refractory Solid Tumors With TP53 Mutations Register Study

Who this might be right for
Solid Tumor, Adult
Tianjin Medical University Second Hospital 100
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