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Results for “Tp53 Mutations”

83 trials

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Showing 20 of 83 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT05280626
What this trial is testing

First-line Treatment of P53 Mutation With PD-L1 Expression in DLBCL With Anti-PD-1 Mab and R-CHOP

Who this might be right for
Diffuse Large B-Cell Lymphoma
Innovent Biologics (Suzhou) Co. Ltd. 100
Early research (Phase 1)Looking for participantsNCT06908434
What this trial is testing

A Phase I First-in-Human Study of GenSci128 in Patients With Solid Tumors Harboring a TP53 Y220C Mutation

Who this might be right for
Solid Tumors Harboring a TP53 Y220C Mutation
Changchun GeneScience Pharmaceutical Co., Ltd. 82
Testing effectiveness (Phase 2)Looking for participantsNCT04585750
What this trial is testing

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Who this might be right for
Advanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more
PMV Pharmaceuticals, Inc 300
Testing effectiveness (Phase 2)Active Not RecruitingNCT05491811
What this trial is testing

Ensartinib in Combination With Bevacizumab in ALK-positive NSCLC Patients With TP53 Mutation

Who this might be right for
Non-Small Cell Lung Cancer
Sun Yat-sen University 49
Early research (Phase 1)Looking for participantsNCT06795009
What this trial is testing

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Who this might be right for
Uterine CancerEndometrial Cancer
Washington University School of Medicine 36
Not applicableLooking for participantsNCT07242963
What this trial is testing

Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study

Who this might be right for
Medulloblastoma RecurrentMedulloblastoma, Childhood, RecurrentMedulloblastoma, SHH-activated and TP53 Mutant+1 more
Mohammad H. Abu Arja 300
Not applicableUnknownNCT03927599
What this trial is testing

Advanced Refractory Solid Tumors With TP53 Mutations Register Study

Who this might be right for
Solid Tumor, Adult
Tianjin Medical University Second Hospital 100
Early research (Phase 1)UnknownNCT03645200
What this trial is testing

Treatment of Carrying TP53 Harmful Mutations

Who this might be right for
Advanced Cancer
Tianjin Medical University Second Hospital 60
Testing effectiveness (Phase 2)WithdrawnNCT06690281
What this trial is testing

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

Who this might be right for
Gastrointestinal CarcinomaPancreatic CancerHepatocellular Cancer+5 more
National Cancer Institute (NCI)
Not applicableUnknownNCT04489706
What this trial is testing

Arsenic Trioxide in Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation

Who this might be right for
Ovarian CancerEndometrial Cancer
Ruijin Hospital 20
Large-scale testing (Phase 3)Not Yet RecruitingNCT05489848
What this trial is testing

Chemotherapy vs Chemoradiotherapy for Post-operative Endometrial Cancer Patients With P53-mutation

Who this might be right for
Endometrial Cancer
Fudan University 294
Early research (Phase 1)Active Not RecruitingNCT02432963
What this trial is testing

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

Who this might be right for
Adult Solid NeoplasmBladder CarcinomaColon Carcinoma+14 more
City of Hope Medical Center 11
Large-scale testing (Phase 3)WithdrawnNCT03377725
What this trial is testing

Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS)

Who this might be right for
Myelodysplastic SyndromesP53 Mutation
Li Junmin
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Large-scale testing (Phase 3)Active Not RecruitingNCT03836261
What this trial is testing

Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

Who this might be right for
Chronic Lymphocytic Leukemia
Acerta Pharma BV 984
Very early researchEnded earlyNCT03272633
What this trial is testing

Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies

Who this might be right for
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia in RemissionHematopoietic Cell Transplantation Recipient+16 more
Rutgers, The State University of New Jersey 2
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+19 more
Masonic Cancer Center, University of Minnesota 70
Large-scale testing (Phase 3)Not Yet RecruitingNCT07342478
What this trial is testing

ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL

Who this might be right for
CLL / SLLCLL (Chronic Lymphocytic Leukemia)CLL, Refractory+5 more
Newave Pharmaceutical Inc 306
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
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