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Results for “Tp53 Mutations”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Looking for participantsNCT06386146
What this trial is testing

JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation

Who this might be right for
Solid Tumors
Jacobio Pharmaceuticals Co., Ltd. 144
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Testing effectiveness (Phase 2)Ended earlyNCT03149679
What this trial is testing

The p53 Colorectal Cancer Trial

Who this might be right for
Colorectal Cancer MetastaticColorectal Cancer Stage IVTP53 Gene Mutation
Haukeland University Hospital 12
Early research (Phase 1)Looking for participantsNCT05877599
What this trial is testing

NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Who this might be right for
Non-small Cell Lung CancerHead and Neck Squamous Cell CarcinomaColorectal Carcinoma+5 more
AstraZeneca 45
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07752875
What this trial is testing

LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

Who this might be right for
Ovarian CancerSmall Cell Lung CancerNon Small Cell Lung Cancer+7 more
LG Chem 250
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Testing effectiveness (Phase 2)Study completedNCT01357161
What this trial is testing

Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)

Who this might be right for
Ovarian Cancer
Merck Sharp & Dohme LLC 136
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Testing effectiveness (Phase 2)UnknownNCT04023916
What this trial is testing

Sintilimab Plus R-CHOP as the First-line Treatment in Patients With Diffuse Large B-Cell Lymphoma.

Who this might be right for
Diffuse Large B-Cell LymphomaSintilimabTP53 Mutation
Chinese Academy of Medical Sciences 30
Testing effectiveness (Phase 2)Ended earlyNCT02688907
What this trial is testing

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation

Who this might be right for
Small Cell Lung Cancer
Samsung Medical Center 7
Large-scale testing (Phase 3)WithdrawnNCT03377725
What this trial is testing

Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS)

Who this might be right for
Myelodysplastic SyndromesP53 Mutation
Li Junmin
Testing effectiveness (Phase 2)WithdrawnNCT06690281
What this trial is testing

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

Who this might be right for
Gastrointestinal CarcinomaPancreatic CancerHepatocellular Cancer+5 more
National Cancer Institute (NCI)
Not applicableStudy completedNCT00505466
What this trial is testing

Transition From Research to Disclosure in Human Genetics

Who this might be right for
Education
M.D. Anderson Cancer Center 577
Testing effectiveness (Phase 2)Study completedNCT03789175
What this trial is testing

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

Who this might be right for
CancerSkin FibroblastsMuscle Weakness
National Heart, Lung, and Blood Institute (NHLBI) 1
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Not applicableEnded earlyNCT03466034
What this trial is testing

The Role of Hypoxia as a Selective Pressure for TP53 Mutations

Who this might be right for
Endometrial Cancer
Institute of Cancer Research, United Kingdom 5
Not applicableLooking for participantsNCT01443468
What this trial is testing

Clinical and Genetic Studies of Li-Fraumeni Syndrome

Who this might be right for
Li-Fraumeni SyndromeNeoplasmsTp53 Mutations
National Cancer Institute (NCI) 5,000
Testing effectiveness (Phase 2)Looking for participantsNCT04585750
What this trial is testing

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Who this might be right for
Advanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more
PMV Pharmaceuticals, Inc 300
Large-scale testing (Phase 3)Study completedNCT01464086
What this trial is testing

LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)

Who this might be right for
Li Fraumeni Syndrome
Gustave Roussy, Cancer Campus, Grand Paris 107
Testing effectiveness (Phase 2)WithdrawnNCT04510584
What this trial is testing

Maintenance Treatment With Bevacizumab and Atezolizumab for Ovarian Cancer

Who this might be right for
Ovarian Endometrioid TumorFallopian Tube CancerPrimary Peritoneal Cancer+1 more
University Health Network, Toronto
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