Very early researchStudy completedNCT03414632What this trial is testingTransthyretin Cardiac Amyloidosis in HFpEFWho this might be right forHeart Failure With Preserved Ejection Fraction Mayo Clinic 287
Early research (Phase 1)Study completedNCT04360434What this trial is testingFirst-in-Human Study of NI006 in Patients With Amyloid Transthyretin CardiomyopathyWho this might be right forAmyloid Transthyretin Cardiomyopathy Neurimmune AG 46
Not applicableStudy completedNCT03322319What this trial is testingFrequency of Cardiac Amyloidosis in the Caribbean's. (TEAM Amylose)Who this might be right forLeft Ventricular Hypertrophy University Hospital Center of Martinique 175
Post-approval studies (Phase 4)Looking for participantsNCT07695701What this trial is testingCardiac Magnetic Resonance and Echocardiography Study With AcoramidisWho this might be right forTransthyretin Amyloidosis Cardiomyopathy (ATTR-CM)AmyloidosisAmyloid Cardiomyopathy+1 more Eidos Therapeutics, a BridgeBio company 150
Large-scale testing (Phase 3)Looking for participantsNCT06128629What this trial is testingMAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)Who this might be right forTransthyretin Amyloidosis (ATTR) With Cardiomyopathy Intellia Therapeutics 1,200
Not applicableLooking for participantsNCT07235462What this trial is testingLearn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world SettingWho this might be right forTransthyretin Amyloid Cardiomyopathy (ATTR-CM) Bayer 2,000
Large-scale testing (Phase 3)Not Yet RecruitingNCT07116473What this trial is testingTo Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)Who this might be right forAmyloidosis in Transthyretin (TTR)Amyloidosis, FamilialAmyloid Cardiomyopathy+7 more Eidos Therapeutics, a BridgeBio company 250
Testing effectiveness (Phase 2)Study completedNCT00694161What this trial is testingThe Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid CardiomyopathyWho this might be right forCardiomyopathy Pfizer 35
Not applicableUnknownNCT05087953What this trial is testingAutonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart DiseaseWho this might be right forAutonomic Nervous System DiseaseAmyloid Neuropathies University of Sao Paulo General Hospital 60
Not applicableStudy completedNCT03237494What this trial is testingTRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive SubjectsWho this might be right forTransthyretin AmyloidosisTransthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy+2 more CENTOGENE GmbH Rostock 5,028
Not applicableUnknownNCT06412432What this trial is testingExercise Training and Rehabilitation In Cardiac AmyloidosisWho this might be right forCardiac Amyloidosis Federico II University 34
Not applicableUnknownNCT05699044What this trial is testingScreening of ATTRwt in Patient With Advanced AV-Block Undergoing Pacemaker ImplantationWho this might be right forAmyloid CardiomyopathyBlock, AV Steen Hvitfeldt Poulsen 170
Not applicableStudy completedNCT02252653What this trial is testingDISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac AmyloidosisWho this might be right forFamilial Amyloidotic Cardiomyopathy (FAC) Alnylam Pharmaceuticals 1,010
Early research (Phase 1)Study completedNCT04601051What this trial is testingStudy to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)Who this might be right forTransthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis Intellia Therapeutics 72
Not applicableActive Not RecruitingNCT04869631What this trial is testingScreening for Amyloidosis Before Aortic Valve Elective ReplacementWho this might be right forAmyloidosisAortic Valve Stenosis Charite University, Berlin, Germany 1,000
Not applicableLooking for participantsNCT07690436What this trial is testingRetinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CMWho this might be right forTransthyretin Amyloid Cardiomyopathy AstraZeneca 500
Post-approval studies (Phase 4)Study completedNCT05233163What this trial is testingSGLT2 Inhibitors in Transthyretin Amyloid CardiomyopathyWho this might be right forTransthyretin Amyloid Cardiomyopathy Columbia University 15
Large-scale testing (Phase 3)Study completedNCT03860935What this trial is testingEfficacy and Safety of AG10 in Subjects With Transthyretin Amyloid CardiomyopathyWho this might be right forAmyloidosisAmyloid CardiomyopathyTransthyretin Amyloidosis+2 more Eidos Therapeutics, a BridgeBio company 632
Not applicableUnknownNCT06345235What this trial is testingNew Biomarkers and Plasma Prothrombotic Potential in Cardiac Transthyretin AmyloidosisWho this might be right forTransthyretin Amyloidosis John Paul II Hospital, Krakow 100
Not applicableNot Yet RecruitingNCT07170306What this trial is testingCardiac Amyloidosis in Patients With Aortic StenosisWho this might be right forAortic StenosisTransthyretin Amyloid Cardiomyopathy Shanghai Zhongshan Hospital 143