Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Treatment Resistant Depression (TRD)”

124 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 124 results

Large-scale testing (Phase 3)Not Yet RecruitingNCT07227103
What this trial is testing

A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial

Who this might be right for
Treatment Resistant DepressionTreatment Resistant Depression (TRD)
NeuroRx, Inc. 400
Large-scale testing (Phase 3)Study completedNCT00789854
What this trial is testing

Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients

Who this might be right for
Major Depressive DisorderTreatment Resistant Depression
AstraZeneca 688
Large-scale testing (Phase 3)Looking for participantsNCT07088380
What this trial is testing

Ketamine Augmentation of ECT in Treatment-Resistant Depression

Who this might be right for
Major Depressive DisorderTreatment Resistant Depression
Università Vita-Salute San Raffaele 30
Not applicableStudy completedNCT07097025
What this trial is testing

2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation

Who this might be right for
Treatment Resistant Depression (TRD)Depression - Major Depressive DisorderBipolar Depression
Dr.Yoav Domany 19
Early research (Phase 1)Not Yet RecruitingNCT07307768
What this trial is testing

Ketamine Biomarker Validation

Who this might be right for
Treatment Resistant Depression (TRD)
Soterix Medical 20
Very early researchLooking for participantsNCT06784388
What this trial is testing

Personalized DBS Targeting for Treating Depression

Who this might be right for
Treatment-resistant Depression (TRD)
Second Affiliated Hospital, Zhejiang University, School of Medicine 5
Not applicableNot Yet RecruitingNCT07824973
What this trial is testing

Ketamine Treatment for Treatment-Resistant Depression - the Role of Framing

Who this might be right for
Treatment Resistant Depression (TRD)
Valdemar Landgren 120
Large-scale testing (Phase 3)Looking for participantsNCT07623135
What this trial is testing

Lumateperone for Late-Life Depression

Who this might be right for
Treatment Resistant Depression (TRD)Late Life Depression (LLD)Depression / Major Depressive Disorder
Eric Lenze 100
Not applicableTemporarily pausedNCT06112652
What this trial is testing

Neuromodulation of Different Doses to Treat TRD Guided by pBFS Technique

Who this might be right for
Moderate DepressionMajor Depressive DisorderSevere Depression
Changping Laboratory 100
Not applicableEnrolling By InvitationNCT07737990
What this trial is testing

Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant Depression

Who this might be right for
Treatment-resistant Depression (TRD)
Joshua Rosenblat 65
Large-scale testing (Phase 3)Study completedNCT03113968
What this trial is testing

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

Who this might be right for
Treatment Resistant DepressionElectroconvulsive TherapyECT+6 more
Bo Hu 403
Post-approval studies (Phase 4)Study completedNCT03149991
What this trial is testing

Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)

Who this might be right for
Depression
Massachusetts General Hospital 51
Post-approval studies (Phase 4)Looking for participantsNCT07080723
What this trial is testing

Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression

Who this might be right for
Treatment Resistant Depression (TRD)
Aalborg University Hospital 80
Post-approval studies (Phase 4)UnknownNCT04352621
What this trial is testing

Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)

Who this might be right for
Major Depressive Disorder
University of Cincinnati 20
Early research (Phase 1)Study completedNCT02911597
What this trial is testing

Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)

Who this might be right for
Depression
Stanford University 16
Testing effectiveness (Phase 2)Study completedNCT00093847
What this trial is testing

Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression

Who this might be right for
Depression
Massachusetts General Hospital 73
Early research (Phase 1)Study completedNCT06965569
What this trial is testing

Multiple Ascending Dose Phase 1 Study of ALA-3000

Who this might be right for
Treatment Resistant Depression
Alar Pharmaceuticals Inc. 37
Not applicableLooking for participantsNCT03320304
What this trial is testing

Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.

Who this might be right for
Treatment Resistant Depression
LivaNova 500
Not applicableLooking for participantsNCT03887715
What this trial is testing

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Who this might be right for
Treatment Resistant Depression
LivaNova 6,800
Not applicableNot Yet RecruitingNCT06542900
What this trial is testing

Efficacy of Deep Brain Stimulation(DBS) for Treatment-Resistant Depression(TRD)

Who this might be right for
Treatment Resistant Depression
Xuanwu Hospital, Beijing 60
Next Page