Post-approval studies (Phase 4)WithdrawnNCT00646087What this trial is testingKetamine Frequency Treatment for Major Depressive DisorderWho this might be right forTreatment Resistant Depression Essentia Health
Not applicableStudy completedNCT03977038What this trial is testingInvestigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in DepressionWho this might be right forMajor Depressive DisorderTreatment Resistant Depression Sunnybrook Health Sciences Centre 25
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07810738What this trial is testingThe BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.Who this might be right forLate Life Treatment Resistant DepressionDepression - Major Depressive DisorderTreatment Resistant Depression Washington University School of Medicine 300
Not applicableUnknownNCT03666390What this trial is testingUsing a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and SuicideWho this might be right forMajor Depressive Disorder Taipei Veterans General Hospital, Taiwan 48
Testing effectiveness (Phase 2)Ended earlyNCT03079297What this trial is testingRapid Antidepressant Effects of LeucineWho this might be right forMajor Depressive Disorder University of Texas Southwestern Medical Center 16
Large-scale testing (Phase 3)Study completedNCT01386086What this trial is testingAripiprazole and Resistant Postpartum DepressionWho this might be right forPostpartum Depression London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's 10
Not applicableNot Yet RecruitingNCT07834762What this trial is testingHome-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant DepressionWho this might be right forTreatment Resistant Depression (TRD)Major Depressive Disorder (MDD) University of California, San Diego 74
Not applicableStudy completedNCT06953362What this trial is testingDeciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major DepressionWho this might be right forTreatment Resistant Depression University of California, San Francisco 6
Testing effectiveness (Phase 2)Study completedNCT00070694What this trial is testingAn Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant DepressionWho this might be right forDepressive Disorder National Institute of Mental Health (NIMH) 96
Not applicableStudy completedNCT00305045What this trial is testingTreating Refractory Major Depressive Disorder With Repetitive Transcranial Magnetic StimulationWho this might be right forMajor Depressive Disorder Centre for Addiction and Mental Health 73
Not applicableUnknownNCT04000022What this trial is testingRepetitive Transcranial Magnetic Stimulation in Pharmaco-naïve Patients With Major DepressionWho this might be right forMajor Depressive Disorder University Hospital, Bonn 20
Not applicableEnded earlyNCT03347487What this trial is testingDBS of the Habenula for Treatment- Resistant Major DepressionWho this might be right forTreatment Resistant Major Depression Disorder Ruijin Hospital 7
Not applicableUnknownNCT04021433What this trial is testingKetamine for Treatment Resistant MDDWho this might be right forDepressive Disorder, Major Hadassah Medical Organization 20
Not applicableStudy completedNCT07097025What this trial is testing2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy RecommendationWho this might be right forTreatment Resistant Depression (TRD)Depression - Major Depressive DisorderBipolar Depression Dr.Yoav Domany 19
Not applicableStudy completedNCT02752178What this trial is testingPeripheral Immunomarker Validation in Treatment-resistant DepressionWho this might be right forDepressive Disorder, Major University of Cambridge 393
Post-approval studies (Phase 4)Study completedNCT00231959What this trial is testingEffectiveness of Pramipexole for Treatment-Resistant DepressionWho this might be right forDepression Massachusetts General Hospital 65
Not applicableStudy completedNCT01507155What this trial is testingAn Open Label Study of Clinical Utility and Patient Outcomes of the Genecept AssayWho this might be right forTreatment Resistant DepressionGeneralized Anxiety Disorder Genomind, LLC 685
Large-scale testing (Phase 3)UnknownNCT01450150What this trial is testingTranscranial Direct Current Stimulation as an Augmenting Intervention for Major DepressionWho this might be right forMajor Depressive Disorder Douglas Mental Health University Institute 30
Testing effectiveness (Phase 2)Study completedNCT02456948What this trial is testingAdjunct Minocyline in Treatment-resistant DepressionWho this might be right forMajor Depressive Disorder Charite University, Berlin, Germany 168
Not applicableStudy completedNCT00533832What this trial is testingPivotal Trial (D02) of Vagus Nerve Stimulation (VNS) for Treatment-Resistant Depression (TRD)Who this might be right forMajor Depressive Disorder Cyberonics, Inc. 266