Testing effectiveness (Phase 2)Ended earlyNCT04141904What this trial is testingTofacitinib in Depression (TIDE)Who this might be right forDepressionInflammation University of Oxford 2
Not applicableTemporarily pausedNCT06112652What this trial is testingNeuromodulation of Different Doses to Treat TRD Guided by pBFS TechniqueWho this might be right forModerate DepressionMajor Depressive DisorderSevere Depression Changping Laboratory 100
Testing effectiveness (Phase 2)Study completedNCT03870776What this trial is testingRESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive EpisodeWho this might be right forDepression Mapreg 126
Not applicableStudy completedNCT06232291What this trial is testingObservation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant DepressionWho this might be right forTreatment-Resistant DepressionMajor Depressive Disorder Medical University of Gdansk 3
Early research (Phase 1)Ended earlyNCT02675556What this trial is testingAllogeneic Human Mesenchymal Stem Cells (hMSCs) Infusion in Patients With Treatment Resistant DepressionWho this might be right forTreatment Resistant Depression Joshua M Hare 1
Not applicableStudy completedNCT00953745What this trial is testingDopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant DepressionWho this might be right forMajor Depressive Disorder Washington University School of Medicine 43
Not applicableStudy completedNCT01597167What this trial is testingMagnesium Sulfate Versus 5% Dextrose With Treatment Resistant DepressionWho this might be right forDepression University of Miami 21
Post-approval studies (Phase 4)Study completedNCT03149991What this trial is testingBrexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)Who this might be right forDepression Massachusetts General Hospital 51
Not applicableWithdrawnNCT01613820What this trial is testingKetamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderWho this might be right forMajor Depressive Disorder Massachusetts General Hospital
Early research (Phase 1)Study completedNCT02577250What this trial is testingKetamine Infusions for PTSD and Treatment-Resistant DepressionWho this might be right forDepressive Disorder, Treatment-ResistantStress Disorders, Post-Traumatic Minneapolis Veterans Affairs Medical Center 20
Testing effectiveness (Phase 2)Study completedNCT04739865What this trial is testingThe Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant DepressionWho this might be right forTreatment Resistant Depression COMPASS Pathways 19
Not applicableLooking for participantsNCT04296097What this trial is testingEvaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)Who this might be right forSevere Permanent Uni or Bilateral Non-pulsatile TinnitusWithout Associated Vestibular PathologyResistant to Therapeutic Failure+1 more University Hospital, Grenoble 7
Not applicableUnknownNCT03972033What this trial is testingRCT Comparing EMDR and CBT for Treatment of Resistant DepressionWho this might be right forEye Movement Desensitization and ReprocessingCognitive Behavioral TherapyNeurobiological Processing+4 more University of Turin, Italy 128
Large-scale testing (Phase 3)Study completedNCT04039022What this trial is testingOpen-Label Safety Study of AXS-05 in Subjects With DepressionWho this might be right forMajor Depressive DisorderTreatment Resistant DepressionDepression Axsome Therapeutics, Inc. 876
Not applicableEnded earlyNCT03360942What this trial is testingLong Term Follow-up of Deep Brain Stimulation for Treatment-Resistant DepressionWho this might be right forTreatment Resistant DepressionDepressive Disorder, Treatment-ResistantDepression, Bipolar Dartmouth-Hitchcock Medical Center 5
Not applicableStudy completedNCT03105700What this trial is testingLow Frequency TMS for Depression in EpilepsyWho this might be right forEpilepsyDepressions, Refractory Dartmouth-Hitchcock Medical Center 15
Post-approval studies (Phase 4)UnknownNCT04352621What this trial is testingStudy to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)Who this might be right forMajor Depressive Disorder University of Cincinnati 20
Testing effectiveness (Phase 2)Looking for participantsNCT07211438What this trial is testingEvaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant DepressionWho this might be right forTreatment-Resistant Depression Centre for Addiction and Mental Health 40
Not applicableNot Yet RecruitingNCT06813313What this trial is testingTheta Burst Stimulation With an 8-Coil Versus H1-Coil for Resistant DepressionWho this might be right forTreatment of Resistant DepressionH1-CoilTheta Burst Stimulation Dominique JANUEL 108
Not applicableStudy completedNCT06708013What this trial is testingThe Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the ChoroidWho this might be right forMajor Depressive Disorder (MDD) Gulhane Training and Research Hospital 30