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Results for “pMMR (Microsatellite Stable Rectal Cancer)”

27 trials

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Showing 20 of 27 results

Testing effectiveness (Phase 2)WithdrawnNCT05582031
What this trial is testing

Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers

Who this might be right for
Anal Squamous Cell CarcinomaColorectal NeoplasmsSoft Tissue Sarcoma+5 more
Translational Research in Oncology
Large-scale testing (Phase 3)Looking for participantsNCT07528209
What this trial is testing

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

Who this might be right for
Rectal CancerpMMR (Microsatellite Stable Rectal Cancer)
Sun Yat-sen University 556
Testing effectiveness (Phase 2)Ended earlyNCT05733611
What this trial is testing

RP2/RP3 in Combination With Atezolizumab and Bevacizumab for the Treatment of Patients With CRC

Who this might be right for
Refractory Metastatic Colorectal CancerpMMRMSS
Replimune, Inc. 5
Testing effectiveness (Phase 2)Looking for participantsNCT06856837
What this trial is testing

- IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases

Who this might be right for
Metastatic Colorectal Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest 140
Testing effectiveness (Phase 2)Study completedNCT04895137
What this trial is testing

MFOLFOX6+Bevacizumab+PD-1 Monoclonal Antibody in Local Advanced MSS CRC

Who this might be right for
Colorectal CancerImmunotherapy
Sixth Affiliated Hospital, Sun Yat-sen University 42
Early research (Phase 1)Ended earlyNCT04108481
What this trial is testing

Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticColon CancerMetastatic Colorectal Cancer+7 more
University of Iowa 5
Testing effectiveness (Phase 2)UnknownNCT05160727
What this trial is testing

Radiotherapy Combined With Tislelizumab and Irinotecan in MSS/pMMR Recurrence and Metastatic Colorectal Cancer

Who this might be right for
Mismatch Repair-proficientColorectal Cancer MetastaticMicrosatellite Stable
Zhejiang Cancer Hospital 44
Not applicableActive Not RecruitingNCT06688786
What this trial is testing

A Pospective, Single-arm, Multicenter Clinical Trial Evaluating Preoperative Neoadjuvant mFOLFOX6 Chemotherapy in Combination With PD1 Monoclonal Antibody in MSS/pMMR Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 30
Testing effectiveness (Phase 2)Study completedNCT04126733
What this trial is testing

Study on the Effectiveness and Safety of the Combination of the Two Drugs Regorafenib and Nivolumab in Patients With Colorectal Cancer (Cancer of the Colon or Rectum Classified as Proficient Mismatch Repair and Microsatellite Stable)

Who this might be right for
Colorectal Cancer
Bayer 70
Testing effectiveness (Phase 2)Looking for participantsNCT06522919
What this trial is testing

Sequential Immunochemotherapy Treatment with Pembrolizumab Plus Dendritic Cell (DC) Vaccine Followed by Trifluridine/Tipiracil Plus Bevacizumab in Refractory Mismatch-repair-proficient (pMMR) or Microsatellite-stable (MSS) Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticMicrosatellite Stable Colorectal CarcinomaRefractory Mismatch-repair-proficient (pMMR) Metastatic Colorectal Cancer
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07359456
What this trial is testing

Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases

Who this might be right for
Metastatic Colorectal Cancer
UNICANCER 130
Large-scale testing (Phase 3)Not Yet RecruitingNCT07277842
What this trial is testing

PD-1 + FOLFOXIRI vs CAPOX as Total Neoadjuvant Therapy for pMMR Low Rectal Cancer

Who this might be right for
Locally Advanced Low Rectal AdenocarcinomapMMR (Microsatellite Stable Rectal Cancer)
Sun Yat-sen University 382
Testing effectiveness (Phase 2)Looking for participantsNCT07079631
What this trial is testing

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
BioNTech SE 482
Testing effectiveness (Phase 2)Looking for participantsNCT07735624
What this trial is testing

RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer

Who this might be right for
Early Rectal CancerStage I Rectal CancerMicrosatellite Stable Rectal Carcinoma
Dana-Farber Cancer Institute 16
Post-approval studies (Phase 4)Not Yet RecruitingNCT07446465
What this trial is testing

FOLFOX Chemotherapy Combined With Fruquintinib and Serplulimab as First-Line Conversion Therapy for Initially Unresectable pMMR/MSS Colorectal Cancer

Who this might be right for
Colorectal Cancer (Locally Advanced or Metastatic)Colorectal Cancer Microsatellite Stable (MSS)
Ye Xu 42
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07381400
What this trial is testing

Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Study)

Who this might be right for
Rectal Cancer
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine 128
Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Testing effectiveness (Phase 2)Looking for participantsNCT06850103
What this trial is testing

SCRT-CAPEOX-Serplulimab for MSS/pMMR Rectal Cancer With Oligometastases

Who this might be right for
Colorectal CarcinomaOligometastasespMMR+2 more
First Affiliated Hospital of Zhejiang University 51
Large-scale testing (Phase 3)Looking for participantsNCT07750158
What this trial is testing

Zanzalintinib Alone or in Combination With Pembrolizumab and Berahyaluronidase Alfa in Participants With Colorectal Cancer With Molecular Residual Disease

Who this might be right for
Colorectal Cancer
Exelixis 600
Testing effectiveness (Phase 2)Active Not RecruitingNCT05205330
What this trial is testing

Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI Cancers

Who this might be right for
Refractory Metastatic Colorectal CancerSolid TumorMetastatic Microsatellite-stable Colorectal Cancer+3 more
Rottapharm Biotech 107
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