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Results for “siRNA”

92 trials

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Showing 20 of 92 results

Testing effectiveness (Phase 2)Study completedNCT03350451
What this trial is testing

An Extension Study of an Investigational Drug, Lumasiran (ALN-GO1), in Participants With Primary Hyperoxaluria Type 1

Who this might be right for
PH1Primary HyperoxaluriaRNAi Therapeutic+2 more
Alnylam Pharmaceuticals 20
Early research (Phase 1)Looking for participantsNCT06452771
What this trial is testing

A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults

Who this might be right for
Healthy Volunteers With Hyperlipidemia
Regeneron Pharmaceuticals 88
Not applicableStudy completedNCT00257647
What this trial is testing

Use of SV40 Vectors to Treat Chronic Myeloid Leukemia (CML)

Who this might be right for
Chronic Myeloid Leukemia
Hadassah Medical Organization 25
Testing effectiveness (Phase 2)Study completedNCT04936035
What this trial is testing

Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension

Who this might be right for
Hypertension
Alnylam Pharmaceuticals 394
Early research (Phase 1)Active Not RecruitingNCT05902520
What this trial is testing

Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors

Who this might be right for
HNSCCMelanomaGynecologic Cancer+3 more
AgonOx, Inc. 18
Early research (Phase 1)Study completedNCT05208996
What this trial is testing

The siCoV/KK46 Drug Open-safety Study

Who this might be right for
COVID-19
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia 10
Testing effectiveness (Phase 2)Study completedNCT02250612
What this trial is testing

SYL040012, Treatment for Open Angle Glaucoma

Who this might be right for
Open Angle GlaucomaOcular Hypertension
Sylentis, S.A. 184
Testing effectiveness (Phase 2)Study completedNCT01739244
What this trial is testing

Dose Finding Clinical Trial With SYL040012 to Evaluate the Tolerability and Effect on Intraocular Pressure in Subjects With Ocular Hypertension or Open Angle Glaucoma

Who this might be right for
Ocular HypertensionOpen Angle Glaucoma
Sylentis, S.A. 80
Testing effectiveness (Phase 2)Study completedNCT04666298
What this trial is testing

Study of Efficacy and Safety of Inclisiran in Japanese Participants With High Cardiovascular Risk and Elevated LDL-C

Who this might be right for
HypercholesterolemiaHeterozygous Familial Hypercholesterolemia
Novartis Pharmaceuticals 312
Early research (Phase 1)Active Not RecruitingNCT01591356
What this trial is testing

EphA2 siRNA in Treating Patients With Advanced or Recurrent Solid Tumors

Who this might be right for
Advanced Malignant Solid Neoplasm
M.D. Anderson Cancer Center 49
Not applicableStudy completedNCT02864329
What this trial is testing

Small RNA Pathways in Mammalian Gametogenesis

Who this might be right for
Male Infertility
Weill Medical College of Cornell University 182
Testing effectiveness (Phase 2)UnknownNCT05637255
What this trial is testing

A Randomized, Double Masked, Parallel Group, Dose-finding Study to Evaluate SYL1801 in Patients With Neovascular Age-related Macular Degeneration (AMD)

Who this might be right for
Wet Macular DegenerationNeovascular Age-related Macular DegenerationMacular Degeneration
Sylentis, S.A. 90
Large-scale testing (Phase 3)Looking for participantsNCT06960213
What this trial is testing

STOP-HAE: A Phase 3 Study of ADX-324 in HAE

Who this might be right for
Hereditary AngioedemaHAEHereditary Angioedema - Type 1+1 more
ADARx Pharmaceuticals, Inc. 90
Testing effectiveness (Phase 2)Looking for participantsNCT03608631
What this trial is testing

IExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

Who this might be right for
KRAS NP_004976.2:p.G12DMetastatic Pancreatic AdenocarcinomaPancreatic Ductal Adenocarcinoma+1 more
M.D. Anderson Cancer Center 28
Testing effectiveness (Phase 2)Looking for participantsNCT06138964
What this trial is testing

Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars

Who this might be right for
KeloidWound HealWound
National Skin Centre 50
Testing effectiveness (Phase 2)Looking for participantsNCT06659640
What this trial is testing

Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)

Who this might be right for
Hereditary Hemorrhagic Telangiectasia
Alnylam Pharmaceuticals 120
Testing effectiveness (Phase 2)Looking for participantsNCT07187401
What this trial is testing

A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Persistent Anemia
Regeneron Pharmaceuticals 24
Testing effectiveness (Phase 2)Ended earlyNCT04012099
What this trial is testing

The Hypertrophic Scar Prevention of BMT101.

Who this might be right for
Hypertrophic Scar
Hugel 20
Testing effectiveness (Phase 2)Study completedNCT05103332
What this trial is testing

Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

Who this might be right for
Hypertension
Alnylam Pharmaceuticals 663
Not applicableNot Yet RecruitingNCT06923280
What this trial is testing

Sequential PEG-IFN for HBV After Ending RNA-targeted Regimens

Who this might be right for
Hepatitis B, Chronic
Huashan Hospital 30
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