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Results for “siRNA”

100 trials

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Showing 20 of 100 results

Early research (Phase 1)Looking for participantsNCT05484206
What this trial is testing

Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434

Who this might be right for
Hepatic ImpairmentCirrhosis
Vir Biotechnology, Inc. 144
Testing effectiveness (Phase 2)Looking for participantsNCT07489209
What this trial is testing

A Dose-exploration Study of EDP167 in HoFH

Who this might be right for
Homozygous Familial Hypercholesterolemia (HoFH)
Eddingpharm (Zhuhai) Co., Ltd. 20
Early research (Phase 1)Looking for participantsNCT06585449
What this trial is testing

Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease

Who this might be right for
Huntington's Disease
Alnylam Pharmaceuticals 66
Early research (Phase 1)Ended earlyNCT02795325
What this trial is testing

DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)

Who this might be right for
Primary Hyperoxaluria Type 1
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 41
Testing effectiveness (Phase 2)Looking for participantsNCT07187401
What this trial is testing

A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Persistent Anemia
Regeneron Pharmaceuticals 24
Testing effectiveness (Phase 2)Ended earlyNCT05761301
What this trial is testing

Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM

Who this might be right for
Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals 49
Testing effectiveness (Phase 2)Ended earlyNCT00395057
What this trial is testing

A Study Using Intravitreal Injections of a Small Interfering RNA in Patients With Age-Related Macular Degeneration

Who this might be right for
Choroid NeovascularizationAge-Related Macular Degeneration
Allergan 138
Testing effectiveness (Phase 2)Study completedNCT06272487
What this trial is testing

Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Who this might be right for
High Cardiovascular RiskHypertension
Alnylam Pharmaceuticals 375
Large-scale testing (Phase 3)Study completedNCT04152200
What this trial is testing

Evaluate Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1

Who this might be right for
Primary Hyperoxaluria Type 1Primary Hyperoxaluria
Alnylam Pharmaceuticals 21
Early research (Phase 1)Looking for participantsNCT07295717
What this trial is testing

Evaluate ALN-4285 in Adult Healthy Volunteers

Who this might be right for
Healthy Volunteers
Alnylam Pharmaceuticals 76
Testing effectiveness (Phase 2)Study completedNCT00259753
What this trial is testing

Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration

Who this might be right for
Macular Degeneration
OPKO Health, Inc. 120
Not applicableUnknownNCT05438069
What this trial is testing

German Inclisiran Network: Retrospective Registry of Patients Being Treated With the siRNA Inclisiran in Germany

Who this might be right for
Hypercholesterolemia
Jena University Hospital 500
Large-scale testing (Phase 3)Study completedNCT05888103
What this trial is testing

Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol.

Who this might be right for
Primary Hypercholesterolemia or Mixed Dyslipidemia
Novartis Pharmaceuticals 207
Early research (Phase 1)Study completedNCT05661916
What this trial is testing

Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects

Who this might be right for
Transthyretin-Mediated Amyloidosis
Alnylam Pharmaceuticals 96
Testing effectiveness (Phase 2)Looking for participantsNCT07463846
What this trial is testing

Evaluate ALN-2232 in Participants With Obesity

Who this might be right for
Obesity
Alnylam Pharmaceuticals 156
Early research (Phase 1)Study completedNCT07412080
What this trial is testing

EDP167 in Healthy Volunteers and Subjects With Mild Dyslipidemia

Who this might be right for
Healthy Adult Male and Female VolunteersMild Dyslipidemia
Eddingpharm (Zhuhai) Co., Ltd. 40
Early research (Phase 1)Active Not RecruitingNCT06669234
What this trial is testing

Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults

Who this might be right for
Healthy Volunteer
Regeneron Pharmaceuticals 56
Testing effectiveness (Phase 2)Study completedNCT00802347
What this trial is testing

I5NP for Prophylaxis of Delayed Graft Function in Kidney Transplantation

Who this might be right for
Delayed Graft FunctionOther Complication of Kidney Transplant
Quark Pharmaceuticals 374
Testing effectiveness (Phase 2)Study completedNCT00306904
What this trial is testing

Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema

Who this might be right for
Diabetic Macular Edema
OPKO Health, Inc. 48
Early research (Phase 1)Ended earlyNCT02110563
What this trial is testing

Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma

Who this might be right for
Solid TumorsMultiple MyelomaNon-Hodgkins Lymphoma+3 more
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 50
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