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Results for “siRNA”

105 trials

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Showing 20 of 105 results

Testing effectiveness (Phase 2)Study completedNCT00259753
What this trial is testing

Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration

Who this might be right for
Macular Degeneration
OPKO Health, Inc. 120
Testing effectiveness (Phase 2)Study completedNCT04270760
What this trial is testing

Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study

Who this might be right for
Cardiovascular Disease
Amgen 281
Testing effectiveness (Phase 2)Looking for participantsNCT05648214
What this trial is testing

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Who this might be right for
Healthy VolunteersMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Regeneron Pharmaceuticals 172
Large-scale testing (Phase 3)Study completedNCT03681184
What this trial is testing

Evaluate Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1

Who this might be right for
Primary Hyperoxaluria Type 1 (PH1)
Alnylam Pharmaceuticals 39
Testing effectiveness (Phase 2)Looking for participantsNCT07187401
What this trial is testing

A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Persistent Anemia
Regeneron Pharmaceuticals 24
Large-scale testing (Phase 3)Study completedNCT05783206
What this trial is testing

Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Mild COVID-19

Who this might be right for
COVID-19
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia 984
Testing effectiveness (Phase 2)Study completedNCT02706886
What this trial is testing

Study of Lumasiran in Healthy Adults and Patients With Primary Hyperoxaluria Type 1

Who this might be right for
Primary Hyperoxaluria Type 1 (PH1)
Alnylam Pharmaceuticals 52
Early research (Phase 1)Active Not RecruitingNCT05902520
What this trial is testing

Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors

Who this might be right for
HNSCCMelanomaGynecologic Cancer+3 more
AgonOx, Inc. 18
Testing effectiveness (Phase 2)UnknownNCT01676259
What this trial is testing

SiG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer

Who this might be right for
Pancreatic Ductal AdenocarcinomaPancreatic Cancer
Silenseed Ltd 80
Large-scale testing (Phase 3)Looking for participantsNCT06597006
What this trial is testing

Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia

Who this might be right for
Familial Hypercholesterolemia - Homozygous
Novartis Pharmaceuticals 9
Testing effectiveness (Phase 2)Study completedNCT05103332
What this trial is testing

Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

Who this might be right for
Hypertension
Alnylam Pharmaceuticals 663
Early research (Phase 1)Ended earlyNCT00927459
What this trial is testing

Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol

Who this might be right for
Hypercholesterolemia
Arbutus Biopharma Corporation 23
Large-scale testing (Phase 3)Study completedNCT03108664
What this trial is testing

HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED)

Who this might be right for
Dry Eye Disease
Sylentis, S.A. 330
Early research (Phase 1)Study completedNCT06115967
What this trial is testing

Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants

Who this might be right for
Rheumatoid Arthritis
AstraZeneca 40
Testing effectiveness (Phase 2)Looking for participantsNCT06138964
What this trial is testing

Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars

Who this might be right for
KeloidWound HealWound
National Skin Centre 50
Early research (Phase 1)Study completedNCT01437007
What this trial is testing

TKM 080301 for Primary or Secondary Liver Cancer

Who this might be right for
Colorectal Cancer With Hepatic MetastasesPancreas Cancer With Hepatic MetastaseGastric Cancer With Hepatic Metastase+2 more
National Cancer Institute (NCI) 1
Large-scale testing (Phase 3)Looking for participantsNCT07181109
What this trial is testing

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Who this might be right for
High Risk Cardiovascular DiseaseHypertensionHigh Cardiovascular Risk
Alnylam Pharmaceuticals 11,000
Early research (Phase 1)Study completedNCT00716014
What this trial is testing

Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita

Who this might be right for
Pachyonychia Congenita
Pachyonychia Congenita Project 1
Testing effectiveness (Phase 2)Study completedNCT00802347
What this trial is testing

I5NP for Prophylaxis of Delayed Graft Function in Kidney Transplantation

Who this might be right for
Delayed Graft FunctionOther Complication of Kidney Transplant
Quark Pharmaceuticals 374
Testing effectiveness (Phase 2)Study completedNCT01776658
What this trial is testing

Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain

Who this might be right for
Ocular PainDry Eye Syndrome
Sylentis, S.A. 60
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