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Results for “siRNA”

110 trials

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Showing 20 of 110 results

Early research (Phase 1)Ended earlyNCT02110563
What this trial is testing

Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma

Who this might be right for
Solid TumorsMultiple MyelomaNon-Hodgkins Lymphoma+3 more
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 50
Early research (Phase 1)Study completedNCT01437007
What this trial is testing

TKM 080301 for Primary or Secondary Liver Cancer

Who this might be right for
Colorectal Cancer With Hepatic MetastasesPancreas Cancer With Hepatic MetastaseGastric Cancer With Hepatic Metastase+2 more
National Cancer Institute (NCI) 1
Early research (Phase 1)Study completedNCT03133130
What this trial is testing

Study to Investigate the Pharmacokinetics, Safety, and Tolerability of BMT101 in Healthy Male Volunteers

Who this might be right for
Hypertrophic Scar
Hugel 32
Large-scale testing (Phase 3)WithdrawnNCT00557791
What this trial is testing

Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD (CARBON)

Who this might be right for
Age Related Macular Degeneration
OPKO Health, Inc.
Testing effectiveness (Phase 2)Study completedNCT06423352
What this trial is testing

Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension

Who this might be right for
Mild to Moderate Hypertension
Alnylam Pharmaceuticals 36
Early research (Phase 1)Ended earlyNCT02795325
What this trial is testing

DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)

Who this might be right for
Primary Hyperoxaluria Type 1
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 41
Testing effectiveness (Phase 2)Active Not RecruitingNCT06659640
What this trial is testing

Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)

Who this might be right for
Hereditary Hemorrhagic Telangiectasia
Alnylam Pharmaceuticals 89
Early research (Phase 1)Study completedNCT01858935
What this trial is testing

A Phase 1, Randomized, Double-Blind, Placebo-Controlled Escalating Single Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ND-L02-s0201 Injection in Normal Healthy Subjects

Who this might be right for
Healthy
Bristol-Myers Squibb 56
Testing effectiveness (Phase 2)Looking for participantsNCT07575308
What this trial is testing

HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB

Who this might be right for
Von Willebrand Disease (VWD)Heavy Menstrual Bleeding (HMB)
Alnylam Pharmaceuticals 24
Early research (Phase 1)Study completedNCT02227459
What this trial is testing

Phase 1b/2, Open Label, Repeat Dose, Dose Escalation Study of ND-L02-s0201 Injection in Subjects With Moderate to Extensive Fibrosis (METAVIR F3-4)

Who this might be right for
Moderate to Extensive Hepatic Fibrosis (METAVIR F3-4)
Bristol-Myers Squibb 25
Early research (Phase 1)Study completedNCT04555486
What this trial is testing

Study to Evaluate Safety, Tolerability, PK and PD of DCR-PHXC in PH Type 3 Patients

Who this might be right for
Primary Hyperoxaluria Type 3
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 6
Early research (Phase 1)Study completedNCT05208996
What this trial is testing

The siCoV/KK46 Drug Open-safety Study

Who this might be right for
COVID-19
National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia 10
Testing effectiveness (Phase 2)Study completedNCT03350451
What this trial is testing

An Extension Study of an Investigational Drug, Lumasiran (ALN-GO1), in Participants With Primary Hyperoxaluria Type 1

Who this might be right for
PH1Primary HyperoxaluriaRNAi Therapeutic+2 more
Alnylam Pharmaceuticals 20
Early research (Phase 1)Looking for participantsNCT07295717
What this trial is testing

Evaluate ALN-4285 in Adult Healthy Volunteers

Who this might be right for
Healthy Volunteers
Alnylam Pharmaceuticals 76
Testing effectiveness (Phase 2)Looking for participantsNCT07738107
What this trial is testing

ATR 1072 in Participants With PRKAG2 Syndrome

Who this might be right for
Cardiac GlycogenosisCardiomyopathyHypertrophic+1 more
Atrium Therapeutics 37
Large-scale testing (Phase 3)Looking for participantsNCT06597006
What this trial is testing

Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia

Who this might be right for
Familial Hypercholesterolemia - Homozygous
Novartis Pharmaceuticals 9
Testing effectiveness (Phase 2)Active Not RecruitingNCT07835971
What this trial is testing

Evaluate Efficacy and Safety of GW906 in Patients With Essential Hypertension

Who this might be right for
Hypertension
Shenzhen Salubris Pharmaceuticals Co., Ltd. 319
Early research (Phase 1)Study completedNCT06115967
What this trial is testing

Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants

Who this might be right for
Rheumatoid Arthritis
AstraZeneca 40
Testing effectiveness (Phase 2)Looking for participantsNCT07463846
What this trial is testing

Evaluate ALN-2232 in Participants With Obesity

Who this might be right for
Obesity
Alnylam Pharmaceuticals 156
Testing effectiveness (Phase 2)Study completedNCT02706886
What this trial is testing

Study of Lumasiran in Healthy Adults and Patients With Primary Hyperoxaluria Type 1

Who this might be right for
Primary Hyperoxaluria Type 1 (PH1)
Alnylam Pharmaceuticals 52
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