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Results for “siRNA”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07835984
What this trial is testing

Evaluate Efficacy and Safety of GW906 Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by One or Two Antihypertensive Medications

Who this might be right for
Hypertension
Shenzhen Salubris Pharmaceuticals Co., Ltd. 560
Early research (Phase 1)Study completedNCT04782271
What this trial is testing

Safety, Tolerability and Pharmacokinetic Profile of SYL1801 Eye Drops

Who this might be right for
Safety, Tolerability and Pharmacokinetic Profile in Healthy VolunteersChoroidal Neovascularization
Sylentis, S.A. 36
Testing effectiveness (Phase 2)Looking for participantsNCT07489209
What this trial is testing

A Dose-exploration Study of EDP167 in HoFH

Who this might be right for
Homozygous Familial Hypercholesterolemia (HoFH)
Eddingpharm (Zhuhai) Co., Ltd. 20
Large-scale testing (Phase 3)Study completedNCT05888103
What this trial is testing

Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol.

Who this might be right for
Primary Hypercholesterolemia or Mixed Dyslipidemia
Novartis Pharmaceuticals 207
Early research (Phase 1)Active Not RecruitingNCT06669234
What this trial is testing

Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults

Who this might be right for
Healthy Volunteer
Regeneron Pharmaceuticals 56
Large-scale testing (Phase 3)Study completedNCT03681184
What this trial is testing

Evaluate Lumasiran in Children and Adults With Primary Hyperoxaluria Type 1

Who this might be right for
Primary Hyperoxaluria Type 1 (PH1)
Alnylam Pharmaceuticals 39
Large-scale testing (Phase 3)Active Not RecruitingNCT05030428
What this trial is testing

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

Who this might be right for
Atherosclerotic Cardiovascular Disease
Novartis Pharmaceuticals 17,004
Large-scale testing (Phase 3)Study completedNCT04659863
What this trial is testing

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial Hypercholesterolemia

Who this might be right for
Familial Hypercholesterolemia - Homozygous
Novartis Pharmaceuticals 13
Testing effectiveness (Phase 2)Looking for participantsNCT05519475
What this trial is testing

A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

Who this might be right for
Metabolic Dysfunction-Associated SteatoHepatitis (MASH)
Regeneron Pharmaceuticals 120
Testing effectiveness (Phase 2)Looking for participantsNCT07187401
What this trial is testing

A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Persistent Anemia
Regeneron Pharmaceuticals 24
Early research (Phase 1)Ended earlyNCT00689065
What this trial is testing

Safety Study of CALAA-01 to Treat Solid Tumor Cancers

Who this might be right for
CancerSolid Tumor
Calando Pharmaceuticals 24
Post-approval studies (Phase 4)Not Yet RecruitingNCT06586684
What this trial is testing

Effect of Small Interfering RNA Inclisiran on Carotid Plaques As Assessed by Carotid Ultrasound

Who this might be right for
Carotid PlaqueHyperlipidemiaEchocardiography
First Affiliated Hospital of Xinjiang Medical University 40
Early research (Phase 1)Looking for participantsNCT07430397
What this trial is testing

A Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CITY-FXI in Healthy Adults and Adults With FV Leiden or Prothrombin G20210A Mutation

Who this might be right for
Factor V LeidenProthrombin G20210A
City Therapeutics 128
Large-scale testing (Phase 3)Study completedNCT03905694
What this trial is testing

Lumasiran in Infants and Young Children With Primary Hyperoxaluria Type 1

Who this might be right for
Primary HyperoxaluriaPrimary Hyperoxaluria Type 1 (PH1)
Alnylam Pharmaceuticals 18
Large-scale testing (Phase 3)Looking for participantsNCT07428499
What this trial is testing

Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)

Who this might be right for
Hereditary Angioedema (HAE)Hereditary Angioedema - Type 1Hereditary Angioedema - Type 2+1 more
ADARx Pharmaceuticals, Inc. 90
Large-scale testing (Phase 3)Study completedNCT05310422
What this trial is testing

Safety Study of Tivanisiran to Treat Dry Eye

Who this might be right for
Dry Eye Disease
Sylentis, S.A. 301
Testing effectiveness (Phase 2)Study completedNCT02250612
What this trial is testing

SYL040012, Treatment for Open Angle Glaucoma

Who this might be right for
Open Angle GlaucomaOcular Hypertension
Sylentis, S.A. 184
Early research (Phase 1)Active Not RecruitingNCT05844293
What this trial is testing

Single Ascending Dose of FXI-GalNAc-siRNA in Healthy Subjects

Who this might be right for
FXI
Sirnaomics 40
Testing effectiveness (Phase 2)Looking for participantsNCT07432867
What this trial is testing

Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.

Who this might be right for
Sickle Cell Disease
Assistance Publique - Hôpitaux de Paris 15
Testing effectiveness (Phase 2)Looking for participantsNCT07610278
What this trial is testing

Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia

Who this might be right for
Hypercholesterolaemia
Novartis Pharmaceuticals 120
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