Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. .
Chromosome
17
Biotype
protein_coding
Diseases
25
Variants
50
Also Known As
25 disease associations found
| Disease | Score | Therapeutic Areas |
|---|---|---|
| non-small cell lung carcinoma | 0.78 | respiratory or thoracic diseasecancer or benign tumor |
| cancer | 0.78 | cancer or benign tumor |
| gastric cancer | 0.73 | gastrointestinal diseasecancer or benign tumor |
| breast carcinoma | 0.70 | reproductive system or breast diseasecancer or benign tumor |
| gastric adenocarcinoma | 0.69 | gastrointestinal diseasecancer or benign tumor |
| neoplasm | 0.68 | cancer or benign tumor |
| urinary bladder cancer | 0.66 | urinary system disordercancer or benign tumor |
| lung adenocarcinoma | 0.64 | cancer or benign tumorrespiratory or thoracic disease |
| breast cancer | 0.63 | reproductive system or breast diseasecancer or benign tumor |
| HER2 positive breast carcinoma | 0.62 | reproductive system or breast diseasecancer or benign tumor |
| breast neoplasm | 0.62 | reproductive system or breast diseasecancer or benign tumor |
| urinary bladder carcinoma | 0.61 | urinary system disordercancer or benign tumor |
| breast adenocarcinoma | 0.59 | integumentary system disordercancer or benign tumorreproductive system or breast disease |
| lung cancer | 0.59 | respiratory or thoracic diseasecancer or benign tumor |
| gastric neoplasm | 0.59 | gastrointestinal diseasecancer or benign tumor |
25 drugs targeting this gene
Epidermal growth factor receptor erbB1 inhibitor
Receptor protein-tyrosine kinase erbB-2 inhibitor
Epidermal growth factor receptor erbB1 inhibitor
Receptor protein-tyrosine kinase erbB-2 inhibitor
Receptor protein-tyrosine kinase erbB-2 binding agent
Receptor protein-tyrosine kinase erbB-2 inhibitor
Receptor protein-tyrosine kinase erbB-2 binding agent
Epidermal growth factor receptor erbB1 inhibitor
Receptor protein-tyrosine kinase erbB-4 inhibitor
Receptor protein-tyrosine kinase erbB-4 inhibitor
Receptor protein-tyrosine kinase erbB-2 inhibitor
Receptor protein-tyrosine kinase erbB-2 inhibitor
Epidermal growth factor receptor erbB1 inhibitor
Receptor protein-tyrosine kinase erbB-2 binding agent
Receptor protein-tyrosine kinase erbB-4 inhibitor
ErbB-2/ErbB-3 heterodimer inhibitor
Ephrin receptor inhibitor
Receptor tyrosine-protein kinase erbB-2 binding agent
Epidermal growth factor receptor inhibitor
Ephrin type-B receptor 4 inhibitor
Epidermal growth factor receptor erbB1 inhibitor
Receptor protein-tyrosine kinase erbB-2 inhibitor
50 variants reported
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