Little is known about the characteristics of genetic mutation in a large multi-gene panel in epithelial ovarian cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy.
Study Type
OBSERVATIONAL
Enrollment
500
A multi-gene panel, which consists of more than 500 hundred genes will be provided for mutation analysis
Lei Li
Beijing, Beijing Municipality, China
RECRUITINGFrequency of genetic mutations
Frequency of various genetic mutations among recruited patients
Time frame: Two years
Total mutation burden
Total mutation burden calculated in definite patient
Time frame: Two years
Frequency of microsatellite Instability
Microsatellite Instability in definite patient
Time frame: Two years
Expression rates of PD-1 and PD-L1 antibodies
Expression rates of PD-1 and PD-L1 antibodies among recruited patients
Time frame: Two years
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