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Results for “AML With Gene Mutations”

96 trials

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Showing 20 of 96 results

Large-scale testing (Phase 3)UnknownNCT04174612
What this trial is testing

AML Patients Bearing FLT3 Mutations Based on Peripheral Blast Clearance

Who this might be right for
Acute Myeloid Leukemia With FLT3/ITD Mutation
Gruppo Italiano Malattie EMatologiche dell'Adulto 172
Testing effectiveness (Phase 2)Active Not RecruitingNCT02677922
What this trial is testing

Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Who this might be right for
Leukemia, Myeloid, Acute
Celgene 130
Not applicableStudy completedNCT04788420
What this trial is testing

Influence of Co-existing Mutations on Sorafenib Maintenance Therapy After Allo-HSCT for Patients With FLT3-ITD AML

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia With FLT3/ITD MutationHematopoietic Stem Cell Transplantation
Nanfang Hospital, Southern Medical University 456
Testing effectiveness (Phase 2)Study completedNCT00079482
What this trial is testing

Study of CEP-701 (Lestaurtinib) in Patients With Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid Leukemia
Cephalon 224
Testing effectiveness (Phase 2)Ended earlyNCT01907815
What this trial is testing

Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Acute Myeloid Leukemia

Who this might be right for
Recurrent Adult Acute Myeloid LeukemiaUntreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI) 24
Early research (Phase 1)Not Yet RecruitingNCT07511062
What this trial is testing

Axatilimab Combined With Decitabine/Venetoclax for the Treatment of TP53-mutated AML

Who this might be right for
Acute Myeloid LeukemiaTP53 Gene Mutation
Northside Hospital, Inc. 32
Not applicableStudy completedNCT01138319
What this trial is testing

Biomarkers in Patients With Acute Myeloid Leukemia

Who this might be right for
Leukemia
Children's Oncology Group 18
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06667973
What this trial is testing

Efficacy of Gilteritinib in Combination With FLAI as Induction Therapy of FLT3-positive Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaFLT3 Gene MutationAdult AML+1 more
Gruppo Italiano Malattie EMatologiche dell'Adulto 80
Testing effectiveness (Phase 2)Study completedNCT01522469
What this trial is testing

Phase II Study of Crenolanib in Subjects With Relapsed/Refractory AML With FLT3 Activating Mutations

Who this might be right for
Relapsed or Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Arog Pharmaceuticals, Inc. 14
Not applicableStudy completedNCT01385150
What this trial is testing

Biomarkers in Blood Samples From Patients With Acute Myeloid Leukemia

Who this might be right for
Leukemia
Eastern Cooperative Oncology Group 220
Not applicableEnded earlyNCT01463410
What this trial is testing

Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the AMLProfiler

Who this might be right for
Acute Myeloid Leukemia (AML)Acute Promyelocytic Leukemia (APL)Refractory Anemia With Excess of Blasts (RAEB)
Skyline Diagnostics BV 264
Testing effectiveness (Phase 2)Looking for participantsNCT07028073
What this trial is testing

A New Treatment of Newly Diagnosed KIT Mutation CBF-Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia With T(8;21)(Q22;Q22)Acute Myeloid Leukemia With T(16;16)(P13;Q22)KIT Gene Mutation+1 more
The First Affiliated Hospital of Soochow University 78
Testing effectiveness (Phase 2)WithdrawnNCT03881735
What this trial is testing

Enasidenib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia With an IDH2 Gene Mutation

Who this might be right for
Blasts Under 5 Percent of Peripheral Blood White CellsBone Marrow Blasts Decreased by 50 Percent or More Compared to Pretreatment LevelIDH2 Gene Mutation+2 more
Roswell Park Cancer Institute
Testing effectiveness (Phase 2)Looking for participantsNCT06561880
What this trial is testing

The Efficacy of Triple Regimen in Newly Diagnosed AML Patients With FLT3 Mutation

Who this might be right for
FLT3 Gene MutationAML
Institute of Hematology & Blood Diseases Hospital, China 36
Large-scale testing (Phase 3)Active Not RecruitingNCT04027309
What this trial is testing

Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic Syndrome With Excess Blasts-2
Stichting Hemato-Oncologie voor Volwassenen Nederland 777
Testing effectiveness (Phase 2)Study completedNCT02400281
What this trial is testing

Study of Crenolanib Combined With Chemotherapy in FLT3-mutated Acute Myeloid Leukemia Patients

Who this might be right for
Acute Myeloid Leukemia
Arog Pharmaceuticals, Inc. 28
Testing effectiveness (Phase 2)Looking for participantsNCT06696183
What this trial is testing

Gilteritinib in Combination With Venetoclax and Azacitidine for AML Patients With FLT3 Mutations Ineligible for Intensive Treatment

Who this might be right for
AML - Acute Myeloid Leukemia
Technische Universität Dresden 60
Testing effectiveness (Phase 2)Study completedNCT05024994
What this trial is testing

E7820 in People With Bone Marrow (Myeloid) Cancers

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia
Memorial Sloan Kettering Cancer Center 12
Large-scale testing (Phase 3)Looking for participantsNCT04293562
What this trial is testing

Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Who this might be right for
Acute Myeloid Leukemia
Children's Oncology Group 1,186
Large-scale testing (Phase 3)Study completedNCT03250338
What this trial is testing

Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML

Who this might be right for
Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Arog Pharmaceuticals, Inc. 106
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