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Results for “Apert Syndrome”

33 trials

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Showing 20 of 33 results

Early research (Phase 1)Study completedNCT01703481
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Adult Participants With Advanced or Refractory Solid Tumors or Lymphoma

Who this might be right for
Tumor or Lymphoma
Janssen Research & Development, LLC 188
Early research (Phase 1)Looking for participantsNCT06160752
What this trial is testing

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

Who this might be right for
Locally Advanced CholangiocarcinomaIntrahepatic CholangiocarcinomaSolid Tumor+1 more
Tyra Biosciences, Inc 40
Early research (Phase 1)Ended earlyNCT03144661
What this trial is testing

An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies

Who this might be right for
Hepatocellular Carcinoma (HCC)CholangiocarcinomaEsophageal Cancer+3 more
Incyte Corporation 25
Not applicableUnknownNCT01927354
What this trial is testing

Study on the Interplay Between Twist1 and Other EMT Regulators Through microRNA-29 Family.

Who this might be right for
Head-and-Neck Squamous Cell Carcinoma
National Taiwan University Hospital 100
Not applicableStudy completedNCT03955913
What this trial is testing

Identify Participants With Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations

Who this might be right for
Urothelial CancerReceptors, Fibroblast Growth Factor
Janssen Research & Development, LLC 3,679
Testing effectiveness (Phase 2)Looking for participantsNCT07292168
What this trial is testing

A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1

Who this might be right for
Renal Cell Carcinoma MetastaticProstate Cancer MetastaticNon-small Cell Lung Cancer Metastatic+2 more
Kidney Cancer Research Bureau 58
Testing effectiveness (Phase 2)Ended earlyNCT01367275
What this trial is testing

Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGF

Who this might be right for
Colorectal CancerColorectal Adenocarcinoma
M.D. Anderson Cancer Center 8
Not applicableNot Yet RecruitingNCT07535372
What this trial is testing

ASO Treatment for Syndromic Craniosynostoses

Who this might be right for
CraniosynostosesCrouzon SyndromeSaethre Chotzen Syndrome+3 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 12
Testing effectiveness (Phase 2)Study completedNCT04045613
What this trial is testing

Derazantinib and Atezolizumab in Patients With Urothelial Cancer

Who this might be right for
Urothelial Carcinoma
Basilea Pharmaceutica 95
Testing effectiveness (Phase 2)WithdrawnNCT02846766
What this trial is testing

Study of Lenvatinib in Patients With Advanced Cancer and Aberrations in FGF/FGFR Signaling

Who this might be right for
Cancer
Teresa Helsten, MD
Testing effectiveness (Phase 2)Looking for participantsNCT04962867
What this trial is testing

NCCH2006/MK010 Trial (FORTUNE Trial)

Who this might be right for
Advanced or Recurrent Solid TumorsFGFR Gene Alterations
National Cancer Center, Japan 75
Testing effectiveness (Phase 2)Study completedNCT04238715
What this trial is testing

E7090 in Participants With Unresectable Advanced or Metastatic Cholangiocarcinoma With Fibroblast Growth Factor Receptor (FGFR) 2 Gene Fusion

Who this might be right for
Cholangiocarcinoma
Eisai Co., Ltd. 63
Not applicableEnded earlyNCT00213889
What this trial is testing

TWIST Human Gene and Cleft Lips and Palates

Who this might be right for
Cleft Lip
University Hospital, Strasbourg, France 45
Testing effectiveness (Phase 2)Ended earlyNCT04003610
What this trial is testing

Pemigatinib + Pembrolizumab vs Pemigatinib Alone vs Standard of Care for Urothelial Carcinoma (FIGHT-205)

Who this might be right for
Metastatic Urothelial CarcinomaUnresectable Urothelial Carcinoma
Incyte Corporation 7
Early research (Phase 1)Active Not RecruitingNCT05567185
What this trial is testing

Erdafitinib Intravesical Delivery System in Japanese Participants With Bladder Cancer

Who this might be right for
Urinary Bladder NeoplasmsReceptors, Fibroblast Growth Factor
Janssen Pharmaceutical K.K. 5
Testing effectiveness (Phase 2)Ended earlyNCT03822117
What this trial is testing

Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)

Who this might be right for
Solid Tumor Malignancy
Incyte Corporation 111
Not applicableLooking for participantsNCT04463316
What this trial is testing

GROWing Up With Rare GENEtic Syndromes

Who this might be right for
Prader-Willi SyndromePWS-like SyndromeSilver Russel Syndrome+30 more
dr. Laura C. G. de Graaff-Herder 600
Testing effectiveness (Phase 2)Study completedNCT04125693
What this trial is testing

Roll-over Study to Continue Treatment With the Investigational Drug Rogaratinib and to Further Test Its Safety

Who this might be right for
Cancer
Bayer 1
Early research (Phase 1)Study completedNCT03235570
What this trial is testing

A Safety and Tolerability Study of Pemigatinib in Japanese Subjects With Advanced Malignancies - (FIGHT-102)

Who this might be right for
Solid Tumors
Incyte Corporation 44
Testing effectiveness (Phase 2)Ended earlyNCT03762122
What this trial is testing

Rogaratinib in Patients With Advanced Pretreated Squamous-cell Non-small Cell Lung Cancer (SQCLC)

Who this might be right for
Squamous-cell Non-small Cell Lung Cancer
Swiss Cancer Institute 15
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