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Results for “BRCA1 Mutation Carrier”

58 trials

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Showing 20 of 58 results

Testing effectiveness (Phase 2)Study completedNCT01009788
What this trial is testing

ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer

Who this might be right for
Breast CancerMetastatic Breast CancerBRCA1 Gene Mutation+1 more
Steven J Isakoff, MD, PhD 63
Early research (Phase 1)Study completedNCT00892736
What this trial is testing

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Who this might be right for
Basal-Like Breast CarcinomaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+14 more
National Cancer Institute (NCI) 98
Large-scale testing (Phase 3)Active Not RecruitingNCT01905046
What this trial is testing

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+2 more
Alliance for Clinical Trials in Oncology 86
Not applicableStudy completedNCT02197000
What this trial is testing

A Nutritional Intervention to Decrease Breast Density Among Female BRCA (BReast CAncer Susceptibility Gene) Carriers

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
Rabin Medical Center 23
Not applicableStudy completedNCT03066856
What this trial is testing

Dietary Intervention and BRCA Penetrance

Who this might be right for
Dietary ModificationBRCA1 MutationBRCA2 Mutation+1 more
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 502
Not applicableLooking for participantsNCT07532434
What this trial is testing

A Bidirectional Cohort Study on Prophylactic Resection Surgery in Populations at Moderate-to-High Risk for Hereditary Ovarian Cancer

Who this might be right for
Ovarian CancerBreast Cancer
Peking University Third Hospital 480
Not applicableLooking for participantsNCT04613440
What this trial is testing

FaCT Trial (Facilitated Cascade Testing Trial)

Who this might be right for
BRCA1 MutationBRCA2 Mutation
Weill Medical College of Cornell University 820
Not applicableStudy completedNCT01219075
What this trial is testing

Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer

Who this might be right for
BRCA1 Mutation CarrierBRCA2 Mutation CarrierDuctal Breast Carcinoma in Situ+6 more
University of Southern California 110
Testing effectiveness (Phase 2)Study completedNCT00580112
What this trial is testing

An Efficacy Study of Trabectedin in the Treatment of Participants With Specific Subtypes of Metastatic Breast Cancer

Who this might be right for
Breast Neoplasms
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 127
Testing effectiveness (Phase 2)Study completedNCT02314156
What this trial is testing

Transdermal or Oral Telapristone Acetate in Treating Patients Undergoing Mastectomy

Who this might be right for
BRCA1 Mutation CarrierBRCA2 Mutation CarrierDuctal Breast Carcinoma In Situ+6 more
Northwestern University 67
Very early researchEnded earlyNCT03382574
What this trial is testing

Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oophorectomy

Who this might be right for
Ovarian Carcinoma
National Cancer Institute (NCI) 2
Early research (Phase 1)Study completedNCT01339650
What this trial is testing

Study of ABT-767 in Subjects With Breast Cancer 1 and Breast Cancer 2 (BRCA 1 and BRCA 2) Mutations and Solid Tumors or High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Fallopian TubePrimary Peritoneal CancerSolid Tumors (e.g. Breast, Ovarian, Prostate, or Pancreatic) and Ovarian
AbbVie (prior sponsor, Abbott) 93
Testing effectiveness (Phase 2)Study completedNCT00664781
What this trial is testing

Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer

Who this might be right for
brca1 Mutation Carrierbrca2 Mutation CarrierBreast Cancer+1 more
Cancer Research UK 78
Early research (Phase 1)Study completedNCT01445418
What this trial is testing

AZD2281 Plus Carboplatin to Treat Breast and Ovarian Cancer

Who this might be right for
Breast CancerOvarian Cancer
National Cancer Institute (NCI) 103
Testing effectiveness (Phase 2)Study completedNCT01506609
What this trial is testing

Study Evaluating Efficacy And Tolerability Of Veliparib in Combination With Temozolomide (TMZ) or In Combination With Carboplatin and Paclitaxel Versus Placebo in Participants With Breast Cancer Gene (BRCA)1 and BRCA2 Mutation and Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
AbbVie 294
Early research (Phase 1)Study completedNCT01154426
What this trial is testing

ABT-888 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors

Who this might be right for
Adult Solid NeoplasmBRCA1 Mutation CarrierBRCA2 Mutation Carrier
National Cancer Institute (NCI) 31
Early research (Phase 1)UnknownNCT01022333
What this trial is testing

The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers

Who this might be right for
Breast Cancer
Women's College Hospital 300
Not applicableStudy completedNCT01874184
What this trial is testing

Group-Based Lifestyle Intervention in Measuring Biomarker Levels in Participants at High Risk for Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaAtypical Lobular Breast HyperplasiaBRCA1 Mutation Carrier+3 more
University of Washington 17
Not applicableActive Not RecruitingNCT02321228
What this trial is testing

Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationOvarian Cancer
University Medical Center Nijmegen 510
Testing effectiveness (Phase 2)Active Not RecruitingNCT02571725
What this trial is testing

PARP-inhibition and CTLA-4 Blockade in BRCA-deficient Ovarian Cancer

Who this might be right for
Ovarian CancerFallopian Tube CancerPeritoneal Neoplasms
New Mexico Cancer Research Alliance 50
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