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Results for “Congenital Lactic Acidosis”

22 trials

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Showing 20 of 22 results

Not applicableStudy completedNCT03025659
What this trial is testing

Lactate Acidosis in Postoperative Hearts

Who this might be right for
Post-cardiac SurgeryHyperlactatemia
University of Florida 43
Testing effectiveness (Phase 2)Active Not RecruitingNCT06402123
What this trial is testing

A Phase 2b Study of Zagociguat in Patients With MELAS

Who this might be right for
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
Tisento Therapeutics 43
Not applicableStudy completedNCT00004353
What this trial is testing

Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

Who this might be right for
Mitochondrial MyopathyMELAS SyndromeLactic Acidosis
National Center for Research Resources (NCRR) 35
Testing effectiveness (Phase 2)Study completedNCT00887562
What this trial is testing

Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes

Who this might be right for
MELAS Syndrome
Michio Hirano 27
Testing effectiveness (Phase 2)Looking for participantsNCT06644534
What this trial is testing

Assess TTI-0102 vs Placebo in MELAS Patients

Who this might be right for
MELAS SyndromeMitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
Thiogenesis Therapeutics, Inc. 12
Not applicableNot Yet RecruitingNCT06013397
What this trial is testing

Effectiveness of Ketogenic Diet in MELAS Syndrome

Who this might be right for
MELAS SyndromeKetogenic Dieting
Second Affiliated Hospital, School of Medicine, Zhejiang University 100
Not applicableNo Longer AvailableNCT01797276
What this trial is testing

Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access

Who this might be right for
Mitochondrial Enzyme Deficiencies
University of Florida
Testing effectiveness (Phase 2)UnknownNCT00068913
What this trial is testing

Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome

Who this might be right for
MELAS Syndrome
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 35
Large-scale testing (Phase 3)Study completedNCT00004490
What this trial is testing

Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis

Who this might be right for
Lactic Acidosis
University of Florida 45
Testing effectiveness (Phase 2)Study completedNCT00004493
What this trial is testing

Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia

Who this might be right for
Lactic Acidosis
University of California, San Diego 75
Not applicableLooking for participantsNCT01694940
What this trial is testing

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

Who this might be right for
Mitochondrial DisordersMitochondrial Genetic DisordersMitochondrial Diseases+2 more
Columbia University 1,000
Testing effectiveness (Phase 2)Study completedNCT04604548
What this trial is testing

The KHENEREXT Study

Who this might be right for
Mitochondrial DiseasesMitochondrial DNA tRNALeu(UUR) m.3243A<G MutationMaternally Inherited Diabetes and Deafness (MIDD)+2 more
Khondrion BV 11
Testing effectiveness (Phase 2)Ended earlyNCT02473445
What this trial is testing

A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease

Who this might be right for
Mitochondrial Diseases
Amgen 22
Testing effectiveness (Phase 2)Enrolling By InvitationNCT06961344
What this trial is testing

An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)

Who this might be right for
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
Tisento Therapeutics 44
Not applicableStudy completedNCT00015015
What this trial is testing

Dichloroacetate Kinetics, Metabolism and Toxicology

Who this might be right for
Lactic Acidosis
National Institute of Environmental Health Sciences (NIEHS) 100
Testing effectiveness (Phase 2)Study completedNCT05972954
What this trial is testing

OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)

Who this might be right for
Primary Mitochondrial Disease
Omeicos Therapeutics GmbH 28
Large-scale testing (Phase 3)Looking for participantsNCT06451757
What this trial is testing

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

Who this might be right for
Mitochondrial DiseasesMaternally Inherited Diabetes and Deafness (MIDD)Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)+1 more
Khondrion BV 220
Testing effectiveness (Phase 2)Looking for participantsNCT06792500
What this trial is testing

A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

Who this might be right for
MELAS SyndromeLebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
George Washington University 24
Not applicableStudy completedNCT00874276
What this trial is testing

Pharmacotoxicology of Trichloroethylene Metabolites

Who this might be right for
Congenital Lactic Acidosis
University of Florida 21
Testing effectiveness (Phase 2)Ended earlyNCT04475549
What this trial is testing

Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)

Who this might be right for
MELAS
Tisento Therapeutics 8
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