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Results for “Endothelin System”

32 trials

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Showing 20 of 32 results

Post-approval studies (Phase 4)Study completedNCT00438503
What this trial is testing

Glucose in Dialysis Water in Diabetics With Chronic Renal Failure

Who this might be right for
Renal Failure, ChronicDiabetic Nephropathies
Regional Hospital Holstebro 18
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06072326
What this trial is testing

DApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation

Who this might be right for
Type 1 Diabetes Mellitus With Diabetic Nephropathy
University Medical Center Groningen 36
Testing effectiveness (Phase 2)Study completedNCT01399580
What this trial is testing

A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With Nephropathy

Who this might be right for
Chronic Kidney DiseaseDiabetic Nephropathy
AbbVie (prior sponsor, Abbott) 48
Early research (Phase 1)WithdrawnNCT01119417
What this trial is testing

The Role of Endothelin in the Supine Hypertension of Autonomic Failure

Who this might be right for
HypertensionPure Autonomic FailureMultiple System Atrophy
Vanderbilt University
Large-scale testing (Phase 3)Study completedNCT01224210
What this trial is testing

Ambrisentan in Patients With Porto-pulmonary Hypertension A Multicenter Open Label Trial

Who this might be right for
Portopulmonary Hypertension
Tufts Medical Center 30
Testing effectiveness (Phase 2)UnknownNCT01617746
What this trial is testing

Examination of the Bronchoprotective Effect of Endothelin Receptor Blockade in Asthma

Who this might be right for
Asthma
University of Glasgow 18
Not applicableStudy completedNCT00814281
What this trial is testing

Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?

Who this might be right for
Airway Inflammation
Marywood University 24
Very early researchLooking for participantsNCT04449198
What this trial is testing

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Who this might be right for
Type 1 Diabetes
Augusta University 24
Testing effectiveness (Phase 2)Active Not RecruitingNCT06256432
What this trial is testing

Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome

Who this might be right for
Hepatorenal SyndromeLiver CirrhosisAcute Kidney Injury+1 more
Noorik Biopharmaceuticals AG 54
Testing effectiveness (Phase 2)Ended earlyNCT00926627
What this trial is testing

Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis

Who this might be right for
SarcoidosisPulmonary Hypertension
Daniel Doberer 32
Testing effectiveness (Phase 2)WithdrawnNCT00406731
What this trial is testing

Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure

Who this might be right for
Ocular PhysiologyOptic DiskRegional Blood Flow
Medical University of Vienna
Testing effectiveness (Phase 2)Ended earlyNCT01050491
What this trial is testing

Study on the Effects of Sitaxsentan on Airway Remodeling in Patients With Severe Asthma

Who this might be right for
Effect of Sitaxsentan on Airway Remodeling in Severe Asthma
Institut National de la Santé Et de la Recherche Médicale, France 17
Very early researchStudy completedNCT01100736
What this trial is testing

Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3)

Who this might be right for
Pulmonary Arterial HypertensionVasodilationVasoconstriction
University of Edinburgh 10
Large-scale testing (Phase 3)Looking for participantsNCT05691244
What this trial is testing

Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke

Who this might be right for
Acute Ischemic StrokeCerebral Stroke
Pharmazz, Inc. 514
Testing effectiveness (Phase 2)Study completedNCT00920764
What this trial is testing

Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors

Who this might be right for
Chronic Kidney DiseaseDiabetic Nephropathy
AbbVie (prior sponsor, Abbott) 92
Testing effectiveness (Phase 2)Study completedNCT00777985
What this trial is testing

Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea

Who this might be right for
Obstructive Sleep ApneaHypertension
University Hospital, Grenoble 19
Testing effectiveness (Phase 2)Looking for participantsNCT06887062
What this trial is testing

Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)

Who this might be right for
Large Vessel VasculitisGiant Cell Arteritis (GCA)Takayasu Arteritis
University of Edinburgh 60
Large-scale testing (Phase 3)Ended earlyNCT00120328
What this trial is testing

To Determine the Effects of Avosentan on Doubling of Serum Creatinine, End Stage Renal Disease and Death in Diabetic Nephropathy

Who this might be right for
Diabetic Nephropathy
Speedel Pharma Ltd. 2,364
Not applicableStudy completedNCT00498498
What this trial is testing

Observational Endothelin and Markers of Cellular Apoptosis In CSF Head Injury

Who this might be right for
Cerebrovascular TraumaNeurohormonesCellular Apoptosis+1 more
Virginia Commonwealth University 51
Large-scale testing (Phase 3)Study completedNCT04047563
What this trial is testing

Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke

Who this might be right for
Cerebral IschemiaCerebral InfarctionStroke, Acute
Pharmazz, Inc. 158
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