Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “First-line Therapy”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Large-scale testing (Phase 3)Study completedNCT02494583
What this trial is testing

Study of Pembrolizumab (MK-3475) as First-Line Monotherapy and Combination Therapy for Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (MK-3475-062/KEYNOTE-062)

Who this might be right for
Gastric Adenocarcinoma
Merck Sharp & Dohme LLC 763
Testing effectiveness (Phase 2)Looking for participantsNCT07759856
What this trial is testing

NK Cells Plus ICI for SCLC Maintenance

Who this might be right for
Small Cell Lung Cancer
Tianjin First Central Hospital 42
Testing effectiveness (Phase 2)Active Not RecruitingNCT03093922
What this trial is testing

Two Dosing Schedules of Atezolizumab in Combination With Gemcitabine and Cisplatin as First-Line Treatment for Metastatic Bladder Cancer

Who this might be right for
Urothelial CarcinomaLocally AdvancedUnresectable
Memorial Sloan Kettering Cancer Center 32
Not applicableNot Yet RecruitingNCT06725537
What this trial is testing

Comprehensive Demographics and Clinical Profile of NSCLC Patients

Who this might be right for
Lung Cancer Non Small Cell
D'Or Institute for Research and Education 500
Large-scale testing (Phase 3)Looking for participantsNCT06901531
What this trial is testing

Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

Who this might be right for
Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or CancerLocally Advanced Unresectable Gastric Adenocarcinoma or CancerMetastatic Gastric Adenocarcinoma or Cancer+1 more
Astellas Pharma Global Development, Inc.
Large-scale testing (Phase 3)Not Yet RecruitingNCT07445295
What this trial is testing

Chiauranib Plus PD-1 Inhibitor, Albumin-paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

Who this might be right for
Metastatic Pancreatic Ductal Adenocarcinoma
Chipscreen Biosciences, Ltd. 558
Large-scale testing (Phase 3)Study completedNCT02314117
What this trial is testing

Ramucirumab (LY3009806) in Combination With Capecitabine and Cisplatin in Participants With Stomach Cancer

Who this might be right for
Metastatic Gastric AdenocarcinomaGastroesophageal Junction Adenocarcinoma
Eli Lilly and Company 645
Early research (Phase 1)WithdrawnNCT01160731
What this trial is testing

Panobinostat, Etoposide, and Cisplatin as First-Line Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Who this might be right for
Lung Cancer
Cancer Trials Ireland
Testing effectiveness (Phase 2)Study completedNCT04623775
What this trial is testing

Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-small Cell Lung CancerRecurrent Non-small Cell Lung CancerMetastatic Non-small Cell Lung Cancer
Bristol-Myers Squibb 468
Not applicableStudy completedNCT00710619
What this trial is testing

Observational Patient Diary Study of Treatment Doses for Patients With Haemophilia With Inhibitors to Factors VIII and IX

Who this might be right for
Congenital Bleeding DisorderHaemophilia A With InhibitorsHaemophilia B With Inhibitors
Novo Nordisk A/S 52
Large-scale testing (Phase 3)Looking for participantsNCT07702032
What this trial is testing

Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)

Who this might be right for
Left-sided Colorectal Cancer
Genmab 960
Large-scale testing (Phase 3)Ended earlyNCT03515629
What this trial is testing

REGN2810 (Anti-PD-1 Antibody), Platinum-based Doublet Chemotherapy, and Ipilimumab (Anti-CTLA-4 Antibody) Versus Pembrolizumab Monotherapy in Patients With Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
Regeneron Pharmaceuticals 5
Testing effectiveness (Phase 2)Ended earlyNCT04933695
What this trial is testing

Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment

Who this might be right for
Non-small Cell Lung Cancer
Amgen 42
Testing effectiveness (Phase 2)Study completedNCT01941407
What this trial is testing

First Line Metastatic Breast Cancer Treatment (ESMERALDA)

Who this might be right for
Metastatic Breast Cancer
ARCAGY/ GINECO GROUP 61
Testing effectiveness (Phase 2)Active Not RecruitingNCT05751187
What this trial is testing

Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients

Who this might be right for
Non-squamous NSCLC
Shanghai Chest Hospital 54
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07333287
What this trial is testing

Single-arm Prospective Clinical Study on First-line Treatment of Pancreatic Cancer Liver Metastases With Arterial Infusion Chemotherapy and Embolization Combined With Dual Immune Checkpoint Inhibitors.

Who this might be right for
Pancreatic Cancer Liver MetastasesImmunotherapy-naive
Shandong Provincial Hospital 38
Testing effectiveness (Phase 2)Study completedNCT02769832
What this trial is testing

Nab-Paclitaxel With Gemcitabine for Relapsed Small Cell Cancer

Who this might be right for
Small Cell Lung Cancer (SCLC)
Muhammad Furqan 32
Testing effectiveness (Phase 2)Study completedNCT00891332
What this trial is testing

Study of S-1 Plus LV for Untreated Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Taiho Pharmaceutical Co., Ltd. 73
Large-scale testing (Phase 3)Study completedNCT01523587
What this trial is testing

LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim 795
Testing effectiveness (Phase 2)UnknownNCT04963595
What this trial is testing

Pyrotinib and Vinorelbine Tartrate Capsules With or Without Inetetamab for First Line Treatment in Patients With Trastuzumab-resistant HER2-positive Advanced Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Zhiyong Yu 100
Next Page
500