Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M)”

42 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 42 results

Large-scale testing (Phase 3)Not Yet RecruitingNCT06719479
What this trial is testing

A Clinical Trial to Evaluate Effect of IAE0972 Combined with Chemotherapy for R/M HNSCC or NPC(Note: It is Currently Phase II.).

Who this might be right for
NPCHNSCCRecurrence+1 more
SUNHO（China）BioPharmaceutical CO., Ltd. 60
Early research (Phase 1)UnknownNCT03799744
What this trial is testing

Safety,Tolerability,and Efficacy of VCN-01 With Durvalumab in R/M Head and Neck Squamous Cell Carcinoma

Who this might be right for
Head and Neck NeoplasmsCarcinoma, Squamous Cell of Head and NeckMetastasis+1 more
Institut Català d'Oncologia 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07354984
What this trial is testing

A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Sun Yat-sen University 30
Testing effectiveness (Phase 2)Ended earlyNCT02822482
What this trial is testing

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss

Who this might be right for
Carcinoma, Squamous Cell of Head and Neck
UNICANCER 11
Testing effectiveness (Phase 2)Looking for participantsNCT06869473
What this trial is testing

Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.

Who this might be right for
Head and Neck Squamous Cell Carcinoma (HNSCC)Recurrent Head and Neck CancerMetastatic Head and Neck Cancer
Gruppo Oncologico del Nord-Ovest 67
Not applicableUnknownNCT04740996
What this trial is testing

Study of Pembrolizumab in the First Line Therapy for R/M HNSCC in China

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Shi Yuankai 30
Not applicableLooking for participantsNCT06686342
What this trial is testing

PDO Based Drug Sensitive Test in R/M HNSCC

Who this might be right for
Head and Neck Squamous Cell CarcinomaPatient Derived OrganoidDrug Sensitive Test in Vitro
Huashan Hospital 100
Early research (Phase 1)Ended earlyNCT04659369
What this trial is testing

Study of Pharmacokinetic, Safety, Immunogenicity and Efficacy of CMAB819 and Nivolumab in R/M HNSCC

Who this might be right for
Squamous Cell Carcinoma of the Head and Neck
Taizhou Mabtech Pharmaceutical Co.,Ltd 21
Testing effectiveness (Phase 2)Study completedNCT01040832
What this trial is testing

EMD 1201081 in Combination With Cetuximab in Second-Line Cetuximab-Naïve Subjects With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Who this might be right for
Squamous Cell Carcinoma of the Head and Neck Cancer
EMD Serono 107
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06508606
What this trial is testing

AK117 (Anti-CD47) + Anti-EGFR for R/M HNSCC

Who this might be right for
Head and Neck Squamous Cell Carcinoma
West China Hospital 10
Testing effectiveness (Phase 2)Looking for participantsNCT05260671
What this trial is testing

Penpulimab in Combination With Cetuximab as First-line Treatment in R/M SCCHN

Who this might be right for
Head and Neck NeoplasmsRecurrent DiseaseMetastatic Cancer
Eye & ENT Hospital of Fudan University 48
Testing effectiveness (Phase 2)Ended earlyNCT03020823
What this trial is testing

To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer

Who this might be right for
Head and Neck Neoplasms
SynCore Biotechnology Co., Ltd. 10
Large-scale testing (Phase 3)Study completedNCT05523323
What this trial is testing

Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Merck Sharp & Dohme LLC 112
Testing effectiveness (Phase 2)Study completedNCT02718820
What this trial is testing

Pembrolizumab Plus Docetaxel for the Treatment of Recurrent or Metastatic Head and Neck Cancer

Who this might be right for
Head and Neck Carcinoma
Medical University of Vienna 22
Testing effectiveness (Phase 2)Study completedNCT04997902
What this trial is testing

Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Who this might be right for
HNSCC
Kura Oncology, Inc. 45
Not applicableUnknownNCT05821751
What this trial is testing

The Effect of Prebiotic Inulin on Patients Affected by R/M HNSCC Treated With Immune Checkpoint Inhibitors

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Fondazione del Piemonte per l'Oncologia 40
Not applicableStudy completedNCT05123950
What this trial is testing

Treatment Patterns and Clinical Outcomes in First Line Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (1L R/M SCCHN) Participants in Europe

Who this might be right for
Squamous Cell Carcinoma of the Head and Neck
Bristol-Myers Squibb 304
Testing effectiveness (Phase 2)Looking for participantsNCT06935188
What this trial is testing

Dalpicilib Plus Cetuximab Compared With Cetuximab Alone in HPV-negative, Anti-PD-1-resistant R/M HNSCC

Who this might be right for
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University 98
Testing effectiveness (Phase 2)Study completedNCT04428151
What this trial is testing

Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)

Who this might be right for
Squamous Cell Carcinoma of Head and Neck
Merck Sharp & Dohme LLC 408
Large-scale testing (Phase 3)Active Not RecruitingNCT06295731
What this trial is testing

INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC

Who this might be right for
Head and Neck Squamous Cell Carcinoma (HNSCC)
Inhibrx Biosciences, Inc 410
Load More Results