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Results for “Hedgehog Pathway”

37 trials

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Showing 20 of 37 results

Early research (Phase 1)Study completedNCT01769768
What this trial is testing

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Who this might be right for
Advanced Solid Tumor
Novartis Pharmaceuticals 114
Early research (Phase 1)Study completedNCT00968981
What this trial is testing

Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 67
Testing effectiveness (Phase 2)Study completedNCT00833417
What this trial is testing

A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma

Who this might be right for
Basal Cell Carcinoma
Genentech, Inc. 104
Not applicableUnknownNCT01731262
What this trial is testing

Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis

Who this might be right for
Arthritis, RheumatoidNeovascularization, PathologicSynovitis
Third Affiliated Hospital, Sun Yat-Sen University 78
Testing effectiveness (Phase 2)Study completedNCT00957229
What this trial is testing

To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS)

Who this might be right for
Basal Cell Nevus SyndromeGorlin Syndrome
UCSF Benioff Children's Hospital Oakland 41
Early research (Phase 1)Study completedNCT01209143
What this trial is testing

Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 52
Testing effectiveness (Phase 2)Looking for participantsNCT06422884
What this trial is testing

Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

Who this might be right for
Idiopathic Pulmonary FibrosisProgressive Fibrosing Interstitial Lung Disease
Endeavor Biomedicines, Inc. 200
Testing effectiveness (Phase 2)Study completedNCT01195415
What this trial is testing

Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer

Who this might be right for
Recurrent Pancreatic CarcinomaStage IV Pancreatic Cancer
National Cancer Institute (NCI) 25
Large-scale testing (Phase 3)WithdrawnNCT03070691
What this trial is testing

Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Who this might be right for
Basal Cell Carcinoma
Novartis Pharmaceuticals
Early research (Phase 1)Study completedNCT00670189
What this trial is testing

BMS-833923 (XL139) in Subjects With Advanced or Metastatic Cancer

Who this might be right for
Hedgehog PathwaySmoothenedBasal Cell Carcinoma (BCC)+1 more
Bristol-Myers Squibb 53
Testing effectiveness (Phase 2)Active Not RecruitingNCT01878617
What this trial is testing

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Who this might be right for
Medulloblastoma
St. Jude Children's Research Hospital 660
Testing effectiveness (Phase 2)Study completedNCT01125800
What this trial is testing

A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB

Who this might be right for
MedulloblastomaRhabdomyosarcomaNeuroblastoma+3 more
Novartis Pharmaceuticals 76
Not applicableEnded earlyNCT02221245
What this trial is testing

Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of Esophageal Cancer Patients

Who this might be right for
Esophageal Cancer
University of Miami 24
Early research (Phase 1)Study completedNCT02129101
What this trial is testing

Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies

Who this might be right for
Chronic Myelomonocytic Leukemiade Novo Myelodysplastic SyndromeEssential Thrombocythemia+8 more
Mayo Clinic 63
Early research (Phase 1)Study completedNCT00991718
What this trial is testing

The Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential

Who this might be right for
Healthy
Genentech, Inc. 24
Testing effectiveness (Phase 2)Study completedNCT04416516
What this trial is testing

Safety and Efficacy of ASN-002 Combined With a Hedgehog Pathway Inhibitor

Who this might be right for
Basal Cell CarcinomaBasal Cell Nevus Syndrome
Ascend Biopharmaceuticals Ltd 21
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Very early researchStudy completedNCT02357836
What this trial is testing

Neoadjuvant Itraconazole in Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
University of Texas Southwestern Medical Center 13
Testing effectiveness (Phase 2)Study completedNCT03132636
What this trial is testing

PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy

Who this might be right for
Carcinoma, Basal Cell
Regeneron Pharmaceuticals 138
Testing effectiveness (Phase 2)Study completedNCT01787552
What this trial is testing

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Who this might be right for
Primary MyelofibrosisThrombocytosisEssential Thrombocythemia+7 more
Novartis Pharmaceuticals 50
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