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Results for “Hedgehog Pathway”

37 trials

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Showing 20 of 37 results

Early research (Phase 1)Study completedNCT00607724
What this trial is testing

GDC-0449 in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
Genentech, Inc. 68
Early research (Phase 1)Study completedNCT01209143
What this trial is testing

Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 52
Testing effectiveness (Phase 2)Study completedNCT00959647
What this trial is testing

Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study

Who this might be right for
Ovarian CancerBasal Cell CarcinomaMetastatic Colorectal Cancer
Genentech, Inc. 19
Early research (Phase 1)Study completedNCT02111187
What this trial is testing

A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer

Who this might be right for
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 14
Early research (Phase 1)Study completedNCT00991718
What this trial is testing

The Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential

Who this might be right for
Healthy
Genentech, Inc. 24
Not applicableUnknownNCT01731262
What this trial is testing

Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis

Who this might be right for
Arthritis, RheumatoidNeovascularization, PathologicSynovitis
Third Affiliated Hospital, Sun Yat-Sen University 78
Early research (Phase 1)Study completedNCT01204073
What this trial is testing

TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies

Who this might be right for
Advanced Nonhematologic MalignanciesCarcinoma, Basal Cell
Millennium Pharmaceuticals, Inc. 34
Very early researchStudy completedNCT02357836
What this trial is testing

Neoadjuvant Itraconazole in Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
University of Texas Southwestern Medical Center 13
Testing effectiveness (Phase 2)Looking for participantsNCT05561634
What this trial is testing

Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma

Who this might be right for
Basal Cell CarcinomaRadiotherapy; Complications
University Hospital, Lille 82
Testing effectiveness (Phase 2)Study completedNCT01350115
What this trial is testing

Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Who this might be right for
Basal Cell CarcinomaGorlin SyndromeNevoid Basal Cell Carcinoma Syndrome
Novartis Pharmaceuticals 10
Early research (Phase 1)Study completedNCT01576666
What this trial is testing

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Who this might be right for
Dose EscalationSafetyPreliminary Efficacy+9 more
Novartis Pharmaceuticals 120
Early research (Phase 1)Study completedNCT02129101
What this trial is testing

Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies

Who this might be right for
Chronic Myelomonocytic Leukemiade Novo Myelodysplastic SyndromeEssential Thrombocythemia+8 more
Mayo Clinic 63
Not applicableEnded earlyNCT02221245
What this trial is testing

Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of Esophageal Cancer Patients

Who this might be right for
Esophageal Cancer
University of Miami 24
Not applicableUnknownNCT03972748
What this trial is testing

Use Of Oral Itraconazole In Patients With Locally Limited Basocellular Carcinoma Of Skin.

Who this might be right for
Basal Cell CarcinomaHedgehog Pathway
Hospital de Clinicas de Porto Alegre 28
Testing effectiveness (Phase 2)Study completedNCT03132636
What this trial is testing

PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy

Who this might be right for
Carcinoma, Basal Cell
Regeneron Pharmaceuticals 138
Testing effectiveness (Phase 2)Study completedNCT00739661
What this trial is testing

Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) As Maintenance Therapy in Patients With Ovarian Cancer in a Second or Third Complete Remission

Who this might be right for
Ovarian Cancer
Genentech, Inc. 104
Testing effectiveness (Phase 2)Study completedNCT00957229
What this trial is testing

To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS)

Who this might be right for
Basal Cell Nevus SyndromeGorlin Syndrome
UCSF Benioff Children's Hospital Oakland 41
Testing effectiveness (Phase 2)UnknownNCT04481100
What this trial is testing

CCRT With Itraconazole in Locally Advanced Squamous Esophageal Cancer

Who this might be right for
Esophageal NeoplasmEsophageal DiseasesEsophageal Squamous Cell Carcinoma
Hangzhou Cancer Hospital 38
Early research (Phase 1)Study completedNCT00968981
What this trial is testing

Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 67
Testing effectiveness (Phase 2)Study completedNCT00833417
What this trial is testing

A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma

Who this might be right for
Basal Cell Carcinoma
Genentech, Inc. 104
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