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Results for “Hedgehog Pathway”

37 trials

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Showing 20 of 37 results

Large-scale testing (Phase 3)WithdrawnNCT03070691
What this trial is testing

Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Who this might be right for
Basal Cell Carcinoma
Novartis Pharmaceuticals
Early research (Phase 1)Study completedNCT01106508
What this trial is testing

A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsRecurrent or Refractory MedulloblastomaLocally Advanced or Metastatic Basal Cell Carcinoma
Novartis Pharmaceuticals 57
Very early researchWithdrawnNCT01694589
What this trial is testing

A Pilot Study of a Hedgehog Pathway Inhibitor (LDE-225) in Surgically Resectable Pancreas Cancer

Who this might be right for
Resectable Pancreatic Cancer
Rutgers, The State University of New Jersey
Early research (Phase 1)Study completedNCT02111187
What this trial is testing

A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer

Who this might be right for
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 14
Testing effectiveness (Phase 2)Ended earlyNCT01601184
What this trial is testing

Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway

Who this might be right for
Histologically Confirmed MedulloblastomaActivation of the Sonic Hedgehog (SHH) Pathway
Centre Leon Berard 24
Testing effectiveness (Phase 2)Study completedNCT04416516
What this trial is testing

Safety and Efficacy of ASN-002 Combined With a Hedgehog Pathway Inhibitor

Who this might be right for
Basal Cell CarcinomaBasal Cell Nevus Syndrome
Ascend Biopharmaceuticals Ltd 21
Early research (Phase 1)Study completedNCT00968981
What this trial is testing

Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 67
Testing effectiveness (Phase 2)Study completedNCT00636610
What this trial is testing

Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Genentech, Inc. 199
Early research (Phase 1)Study completedNCT01546519
What this trial is testing

Vismodegib in Patients With Advanced Solid Malignancies Including Hepatocellular Carcinoma With Varying Degrees of Renal or Hepatic Function

Who this might be right for
Cancer
Genentech, Inc. 31
Testing effectiveness (Phase 2)Study completedNCT00739661
What this trial is testing

Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) As Maintenance Therapy in Patients With Ovarian Cancer in a Second or Third Complete Remission

Who this might be right for
Ovarian Cancer
Genentech, Inc. 104
Early research (Phase 1)Study completedNCT01204073
What this trial is testing

TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies

Who this might be right for
Advanced Nonhematologic MalignanciesCarcinoma, Basal Cell
Millennium Pharmaceuticals, Inc. 34
Early research (Phase 1)Study completedNCT02129101
What this trial is testing

Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies

Who this might be right for
Chronic Myelomonocytic Leukemiade Novo Myelodysplastic SyndromeEssential Thrombocythemia+8 more
Mayo Clinic 63
Testing effectiveness (Phase 2)Looking for participantsNCT04018872
What this trial is testing

Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Who this might be right for
Esophagus AdenocarcinomaEsophagus Squamous Cell CarcinomaGastroesophageal Junction Adenocarcinoma
Dallas VA Medical Center 78
Early research (Phase 1)Study completedNCT01209143
What this trial is testing

Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 52
Testing effectiveness (Phase 2)Active Not RecruitingNCT01878617
What this trial is testing

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Who this might be right for
Medulloblastoma
St. Jude Children's Research Hospital 660
Not applicableUnknownNCT03972748
What this trial is testing

Use Of Oral Itraconazole In Patients With Locally Limited Basocellular Carcinoma Of Skin.

Who this might be right for
Basal Cell CarcinomaHedgehog Pathway
Hospital de Clinicas de Porto Alegre 28
Testing effectiveness (Phase 2)Study completedNCT01350115
What this trial is testing

Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Who this might be right for
Basal Cell CarcinomaGorlin SyndromeNevoid Basal Cell Carcinoma Syndrome
Novartis Pharmaceuticals 10
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Testing effectiveness (Phase 2)Study completedNCT00833417
What this trial is testing

A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma

Who this might be right for
Basal Cell Carcinoma
Genentech, Inc. 104
Not applicableEnded earlyNCT02221245
What this trial is testing

Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of Esophageal Cancer Patients

Who this might be right for
Esophageal Cancer
University of Miami 24
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