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Results for “Hedgehog Pathway”

37 trials

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Showing 20 of 37 results

Early research (Phase 1)Study completedNCT01204073
What this trial is testing

TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies

Who this might be right for
Advanced Nonhematologic MalignanciesCarcinoma, Basal Cell
Millennium Pharmaceuticals, Inc. 34
Early research (Phase 1)Study completedNCT01576666
What this trial is testing

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Who this might be right for
Dose EscalationSafetyPreliminary Efficacy+9 more
Novartis Pharmaceuticals 120
Not applicableUnknownNCT01731262
What this trial is testing

Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis

Who this might be right for
Arthritis, RheumatoidNeovascularization, PathologicSynovitis
Third Affiliated Hospital, Sun Yat-Sen University 78
Early research (Phase 1)Study completedNCT01546519
What this trial is testing

Vismodegib in Patients With Advanced Solid Malignancies Including Hepatocellular Carcinoma With Varying Degrees of Renal or Hepatic Function

Who this might be right for
Cancer
Genentech, Inc. 31
Large-scale testing (Phase 3)WithdrawnNCT03070691
What this trial is testing

Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Who this might be right for
Basal Cell Carcinoma
Novartis Pharmaceuticals
Testing effectiveness (Phase 2)Study completedNCT00739661
What this trial is testing

Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) As Maintenance Therapy in Patients With Ovarian Cancer in a Second or Third Complete Remission

Who this might be right for
Ovarian Cancer
Genentech, Inc. 104
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Very early researchWithdrawnNCT01694589
What this trial is testing

A Pilot Study of a Hedgehog Pathway Inhibitor (LDE-225) in Surgically Resectable Pancreas Cancer

Who this might be right for
Resectable Pancreatic Cancer
Rutgers, The State University of New Jersey
Testing effectiveness (Phase 2)Study completedNCT00636610
What this trial is testing

Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Genentech, Inc. 199
Early research (Phase 1)Study completedNCT02111187
What this trial is testing

A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer

Who this might be right for
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 14
Very early researchUnknownNCT02749513
What this trial is testing

Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients

Who this might be right for
Esophageal Cancer
Dallas VA Medical Center 18
Testing effectiveness (Phase 2)Looking for participantsNCT04018872
What this trial is testing

Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Who this might be right for
Esophagus AdenocarcinomaEsophagus Squamous Cell CarcinomaGastroesophageal Junction Adenocarcinoma
Dallas VA Medical Center 78
Testing effectiveness (Phase 2)Study completedNCT01350115
What this trial is testing

Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Who this might be right for
Basal Cell CarcinomaGorlin SyndromeNevoid Basal Cell Carcinoma Syndrome
Novartis Pharmaceuticals 10
Early research (Phase 1)Study completedNCT00607724
What this trial is testing

GDC-0449 in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
Genentech, Inc. 68
Testing effectiveness (Phase 2)Study completedNCT01195415
What this trial is testing

Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer

Who this might be right for
Recurrent Pancreatic CarcinomaStage IV Pancreatic Cancer
National Cancer Institute (NCI) 25
Testing effectiveness (Phase 2)Study completedNCT00957229
What this trial is testing

To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS)

Who this might be right for
Basal Cell Nevus SyndromeGorlin Syndrome
UCSF Benioff Children's Hospital Oakland 41
Testing effectiveness (Phase 2)Active Not RecruitingNCT06422884
What this trial is testing

Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

Who this might be right for
Idiopathic Pulmonary FibrosisProgressive Fibrosing Interstitial Lung Disease
Endeavor Biomedicines, Inc. 213
Testing effectiveness (Phase 2)Study completedNCT00833417
What this trial is testing

A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma

Who this might be right for
Basal Cell Carcinoma
Genentech, Inc. 104
Testing effectiveness (Phase 2)Ended earlyNCT01601184
What this trial is testing

Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway

Who this might be right for
Histologically Confirmed MedulloblastomaActivation of the Sonic Hedgehog (SHH) Pathway
Centre Leon Berard 24
Testing effectiveness (Phase 2)Study completedNCT01787552
What this trial is testing

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Who this might be right for
Primary MyelofibrosisThrombocytosisEssential Thrombocythemia+7 more
Novartis Pharmaceuticals 50
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