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Results for “Hemoglobinuria, Paroxysmal Nocturnal (PNH)”

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Showing 20 of 0 results

Not applicableUnknownNCT00315419
What this trial is testing

Identifying Characteristics of Bone Marrow Failure Syndromes

Who this might be right for
Bone Marrow Failure SyndromesAnemia, AplasticMyelodysplastic Syndromes+4 more
Office of Rare Diseases (ORD) 450
Large-scale testing (Phase 3)Study completedNCT03818607
What this trial is testing

A Study Evaluating the Efficacy and Safety of ABP 959 Compared With Eculizumab in Adult Participants With PNH

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Amgen 42
Large-scale testing (Phase 3)Study completedNCT03500549
What this trial is testing

Study to Evaluate the Efficacy and Safety of APL-2 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Apellis Pharmaceuticals, Inc. 80
Large-scale testing (Phase 3)Active Not RecruitingNCT04434092
What this trial is testing

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche 210
Not applicableLooking for participantsNCT06312644
What this trial is testing

Study of Ultomiris® (Ravulizumab) Safety in Pregnancy

Who this might be right for
Ultomiris-exposed Pregnant/ PostpartumPregnancyParoxysmal Nocturnal Hemoglobinuria (PNH)+3 more
Alexion Pharmaceuticals, Inc. 75
Large-scale testing (Phase 3)Study completedNCT05630001
What this trial is testing

Single Arm, Open Label Trial With Iptacopan Treatment for 24 Weeks, in Patients on Stable Regimen of Anti-C5 Who Switch to Iptacopan.

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Novartis Pharmaceuticals 52
Testing effectiveness (Phase 2)Study completedNCT00397813
What this trial is testing

Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

Who this might be right for
Atypical Chronic Myeloid Leukemia, BCR-ABL1 NegativeChronic Myelomonocytic Leukemiade Novo Myelodysplastic Syndrome+11 more
Fred Hutchinson Cancer Center 77
Not applicableStudy completedNCT00856388
What this trial is testing

Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders

Who this might be right for
Accelerated Phase Chronic Myelogenous LeukemiaAcute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic SyndromeAdult Acute Lymphoblastic Leukemia in Remission+97 more
Roswell Park Cancer Institute 62
Not applicableStudy completedNCT01020188
What this trial is testing

Study of Global Coagulation Tests in Patients With Paroxysmal Nocturnal Haemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Haemoglobinuria
King's College Hospital NHS Trust 60
Testing effectiveness (Phase 2)Study completedNCT00145613
What this trial is testing

Haploidentical Stem Cell Transplant for Treatment Refractory Hematological Malignancies

Who this might be right for
Acute Lymphoblastic Leukemia (ALL)Acute Myeloid Leukemia (AML)Secondary AML+7 more
St. Jude Children's Research Hospital 25
Large-scale testing (Phase 3)Active Not RecruitingNCT04654468
What this trial is testing

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche 51
Testing effectiveness (Phase 2)Study completedNCT00587054
What this trial is testing

Trial of Allogeneic Stem Cell Transplants From HLA Compatible, Related and Unrelated Donors After a Myeloablative Preparative Regimen With Hyperfractionated TBI, Thiotepa and Fludarabine For Adult Patients With Lymphohematopoietic Disorders

Who this might be right for
Allogeneic Stem Cell TransplantLeukemiaNon-Hodgkins+3 more
Memorial Sloan Kettering Cancer Center 129
Testing effectiveness (Phase 2)Study completedNCT00566696
What this trial is testing

Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies

Who this might be right for
Leukemia, Acute Lymphocytic (ALL)Leukemia, Myeloid, Acute(AML)Leukemia, Myeloid, Chronic(CML)+5 more
St. Jude Children's Research Hospital 73
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07266155
What this trial is testing

Efficacy, Safety, and Pharmacokinetics of LP-005 Injection in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Longbio Pharma 30
Large-scale testing (Phase 3)Active Not RecruitingNCT04747613
What this trial is testing

Long-term Safety and Tolerability of Iptacopan in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Novartis Pharmaceuticals 208
Large-scale testing (Phase 3)Active Not RecruitingNCT04432584
What this trial is testing

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche 190
Not applicableStudy completedNCT01364363
What this trial is testing

Unrelated Donor Stem Cell Transplantation

Who this might be right for
Severe Aplastic AnemiaParoxysmal Nocturnal HemoglobinuriaAcute Myelogenous Leukemia+10 more
Scripps Health 64
Large-scale testing (Phase 3)Active Not RecruitingNCT05389449
What this trial is testing

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 80
Large-scale testing (Phase 3)Ended earlyNCT03829449
What this trial is testing

RVA576 (Coversin) Long Term Safety and Efficacy Surveillance Study

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
AKARI Therapeutics 15
Early research (Phase 1)Study completedNCT06326814
What this trial is testing

Test if SAR443809 is Tolerated and Safe When Taken as a Single Dose in Healthy Adults

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Sanofi 54
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