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Results for “Hereditary Optic Neuropathies”

135 trials

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Showing 20 of 135 results

Early research (Phase 1)Study completedNCT00006246
What this trial is testing

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Who this might be right for
Brain and Central Nervous System TumorsChildhood Germ Cell TumorLeukemia+4 more
Pediatric Brain Tumor Consortium 28
Testing effectiveness (Phase 2)Study completedNCT02693119
What this trial is testing

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy

Who this might be right for
Leber's Hereditary Optic Neuropathy
Stealth BioTherapeutics Inc. 12
Not applicableNot Yet RecruitingNCT07313085
What this trial is testing

Mechanisms of Fecal Incontinence in Wolfram Syndrome

Who this might be right for
Wolfram SyndromeFecal Incontinence
Hôpital Necker-Enfants Malades 20
Early research (Phase 1)Study completedNCT01744704
What this trial is testing

Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers

Who this might be right for
Healthy
Dompé Farmaceutici S.p.A 74
Post-approval studies (Phase 4)Study completedNCT00312325
What this trial is testing

Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans

Who this might be right for
Regional Blood FlowOptic Disk
Medical University of Vienna 24
Not applicableStudy completedNCT04909398
What this trial is testing

Pupil Dynamics and Color Vision for the Detection of Eye Diseases

Who this might be right for
Retinitis PigmentosaLeber's Hereditary Optic NeuropathyStargardt Disease
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts 60
Not applicableStudy completedNCT02771379
What this trial is testing

Post Authorisation Safety Study With Raxone in LHON Patients

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 229
Early research (Phase 1)Not Yet RecruitingNCT07258667
What this trial is testing

Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic Neuropathy

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)Leber's Hereditary Optic Neuropathy (LHON)Mitochondrial Disease+1 more
University Hospital, Angers 13
Not applicableEnded earlyNCT02982499
What this trial is testing

Biomechanics of Optic Neuropathy

Who this might be right for
Optic Neuropathy
University of Miami 10
Not applicableLooking for participantsNCT03988764
What this trial is testing

Monogenic Diabetes Misdiagnosed as Type 1

Who this might be right for
Diabetes Mellitus, Type 1Monogenic DiabetesNeonatal Diabetes+4 more
McGill University Health Centre/Research Institute of the McGill University Health Centre 5,000
Large-scale testing (Phase 3)Looking for participantsNCT04912843
What this trial is testing

Gene Therapy Clinical Trial for the Treatment Of Leber's HereDitary Optic Neuropathy

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Wuhan Neurophth Biotechnology Limited Company 102
Testing effectiveness (Phase 2)UnknownNCT04940572
What this trial is testing

Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome

Who this might be right for
Wolfram Syndrome
Centre d'Etude des Cellules Souches 23
Not applicableEnded earlyNCT03886753
What this trial is testing

Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products

Who this might be right for
ALSAutism Spectrum DisorderCancer+15 more
Children's Hospital of Philadelphia 10
Not applicableWithdrawnNCT01302327
What this trial is testing

GLP Analogs for Diabetes in Wolfram Syndrome Patients

Who this might be right for
Diabetes Mellitus Associated With Genetic SyndromeWolfram Syndrome
Hadassah Medical Organization
Large-scale testing (Phase 3)Active Not RecruitingNCT07406854
What this trial is testing

A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)
Wuhan Neurophth Biotechnology Limited Company 95
Early research (Phase 1)Ended earlyNCT00550498
What this trial is testing

Stem Cell Transplantation in Ocular Lesions of Behcet's Disease

Who this might be right for
RetinitisBehcet's Syndrome
Tehran University of Medical Sciences 5
Testing effectiveness (Phase 2)Study completedNCT03140969
What this trial is testing

Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Who this might be right for
Leber's Congenital Amaurosis
Laboratoires Thea 11
Testing effectiveness (Phase 2)Study completedNCT02839720
What this trial is testing

Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma

Who this might be right for
Cutaneous NeurofibromaNeurofibromatosis Type 1Optic Nerve Glioma
National Cancer Institute (NCI) 11
Not applicableStudy completedNCT01421381
What this trial is testing

RHODOS Follow-up Single-visit Study

Who this might be right for
Leber's Hereditary Optic Neuropathy
Santhera Pharmaceuticals 60
Large-scale testing (Phase 3)Looking for participantsNCT06760546
What this trial is testing

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

Who this might be right for
Hypothalamic ObesityMultiple Pituitary Hormone Deficiency Genetic FormSepto-Optic Dysplasia+3 more
Rhythm Pharmaceuticals, Inc. 39
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