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Results for “Hyperammonemia”

36 trials

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Showing 20 of 36 results

Post-approval studies (Phase 4)Study completedNCT02246218
What this trial is testing

The Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders

Who this might be right for
Urea Cycle Disorder
Amgen 27
Not applicableEnrolling By InvitationNCT03655223
What this trial is testing

Early Check: Expanded Screening in Newborns

Who this might be right for
Spinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more
RTI International 30,000
Early research (Phase 1)Study completedNCT06178718
What this trial is testing

Evaluate PK Profile and Food Effects on PK Parameters of TNP-2092 Capsules

Who this might be right for
Hyperammonemia
TenNor Therapeutics (Suzhou) Limited 58
Testing effectiveness (Phase 2)Looking for participantsNCT06255782
What this trial is testing

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency

Who this might be right for
Ornithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseOrnithine Carbamoyltransferase Deficiency (Disorder)+1 more
iECURE, Inc. 20
Testing effectiveness (Phase 2)WithdrawnNCT03884959
What this trial is testing

A Safety and Efficacy Study of Infusions of HepaStem in Urea Cycle Disorders Pediatric Patients

Who this might be right for
Urea Cycle Disorder
HLB Cell Co., Ltd.
Not applicableStudy completedNCT06721845
What this trial is testing

Non-Cirrhotic Hyperammonemia Versus Hyperlactatemia in Septic Patients and Impact of Treatment

Who this might be right for
Sepsis
Menoufia University 60
Not applicableLooking for participantsNCT06805695
What this trial is testing

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

Who this might be right for
Ornithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseUrea Cycle Disorders, Inborn
iECURE, Inc. 13
Testing effectiveness (Phase 2)Study completedNCT01599286
What this trial is testing

Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia

Who this might be right for
Propionic Acidemia, Type I and/or Type IIMethylmalonic AcidemiaCarbamoyl-Phosphate Synthase I Deficiency Disease+1 more
Mendel Tuchman 35
Large-scale testing (Phase 3)Study completedNCT00947297
What this trial is testing

Study of the Safety of HPN (Hyperion)-100 for the Long-Term Treatment of Urea Cycle Disorders (Treat UCD)

Who this might be right for
Urea Cycle Disorders
Amgen 60
Large-scale testing (Phase 3)Study completedNCT01347073
What this trial is testing

Study of the Safety, Pharmacokinetics and Efficacy of HPN-100, in Pediatric Subjects With Urea Cycle Disorders (UCDs)

Who this might be right for
Urea Cycle Disorders
Amgen 23
Post-approval studies (Phase 4)Study completedNCT01257737
What this trial is testing

To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs)

Who this might be right for
Urea Cycle Disorders
Amgen 88
Not applicableLooking for participantsNCT04602325
What this trial is testing

Systemic Biomarkers of Brain Injury From Hyperammonemia

Who this might be right for
Urea Cycle DisorderOrganic AcidemiaMaple Syrup Urine Disease+3 more
Children's National Research Institute 24
Not applicableStudy completedNCT01569568
What this trial is testing

Investigation of Brain Nitrogen in Partial Ornithine Transcarbamylase Deficiency (OTCD) Using 1 H MRS, DTI, and fMRI

Who this might be right for
Ornithine Transcarbamylase Deficiency
Andrea Gropman 49
Testing effectiveness (Phase 2)Study completedNCT00947544
What this trial is testing

Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders

Who this might be right for
Urea Cycle Disorders
Amgen 17
Early research (Phase 1)Ended earlyNCT05349435
What this trial is testing

A Healthy Volunteer Study to Compare Fezagepras (PBI-4050) With Sodium Phenylbutyrate

Who this might be right for
Hyperammonemia
Liminal BioSciences Ltd. 8
Testing effectiveness (Phase 2)WithdrawnNCT04984798
What this trial is testing

Vitamin E Efficacy in HI/HA

Who this might be right for
Hyperinsulinism-Hyperammonemia Syndrome
Children's Hospital of Philadelphia
Testing effectiveness (Phase 2)Study completedNCT01966419
What this trial is testing

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)

Who this might be right for
Acute Episode of Overt Hepatic EncephalopathyHepatic Encephalopathy
Ocera Therapeutics, Inc. 231
Not applicableStudy completedNCT04771104
What this trial is testing

The Effect of Induced Hyperammonaemia on Sleep and Melanopsin-mediated Pupillary Light Response in Patients With Liver Cirrhosis

Who this might be right for
Hepatic EncephalopathyLiver CirrhosisSleep Disturbance
Rigshospitalet, Denmark 9
Early research (Phase 1)Study completedNCT00645879
What this trial is testing

Anaplerotic Therapy in Propionic Acidemia

Who this might be right for
Propionic Acidemia
Nicola Longo 3
Not applicableLooking for participantsNCT07499349
What this trial is testing

Establishment of a Phamacokinetik Model for Erwinase Pharmacokinetiks: The Aim of This Sub Study is to Optimize Target Trough Attainment While Minimizing High Exposures That Impose Increased Risk of Side Effects Such as Hyperammonemia

Who this might be right for
Acute Lymphoblastic Leukemia
Aarhus University Hospital 475
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