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Results for “Hyperammonemia”

35 trials

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Showing 20 of 35 results

Large-scale testing (Phase 3)WithdrawnNCT04128462
What this trial is testing

MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function

Who this might be right for
Hepatic Encephalopathy
Mallinckrodt
Post-approval studies (Phase 4)Study completedNCT01257737
What this trial is testing

To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs)

Who this might be right for
Urea Cycle Disorders
Amgen 88
Testing effectiveness (Phase 2)Study completedNCT06135675
What this trial is testing

PK Profile and Preliminary Efficacy of TNP-2092 Capsules in Liver Cirrhosis Patients With Hyperammonemia

Who this might be right for
Hyperammonemia
TenNor Therapeutics (Suzhou) Limited 36
Not applicableLooking for participantsNCT06805695
What this trial is testing

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

Who this might be right for
Ornithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseUrea Cycle Disorders, Inborn
iECURE, Inc. 13
Not applicableLooking for participantsNCT04602325
What this trial is testing

Systemic Biomarkers of Brain Injury From Hyperammonemia

Who this might be right for
Urea Cycle DisorderOrganic AcidemiaMaple Syrup Urine Disease+3 more
Children's National Research Institute 24
Not applicableLooking for participantsNCT06600659
What this trial is testing

Determine Number of Patients Who Develop High Ammonia Levels After Receiving Recombinant Erwinia Asparaginase

Who this might be right for
Hematopoietic and Lymphatic System NeoplasmAcute Lymphobkastic Leukemia
Mayo Clinic 10
Testing effectiveness (Phase 2)Study completedNCT01966419
What this trial is testing

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)

Who this might be right for
Acute Episode of Overt Hepatic EncephalopathyHepatic Encephalopathy
Ocera Therapeutics, Inc. 231
Large-scale testing (Phase 3)Study completedNCT01347073
What this trial is testing

Study of the Safety, Pharmacokinetics and Efficacy of HPN-100, in Pediatric Subjects With Urea Cycle Disorders (UCDs)

Who this might be right for
Urea Cycle Disorders
Amgen 23
Not applicableEnded earlyNCT02059356
What this trial is testing

Ammonia Levels and Cognitive Impairment

Who this might be right for
DementiaCognitive DeclineCognitive Impairment+1 more
Duke University 17
Not applicableEnrolling By InvitationNCT06987604
What this trial is testing

Continuous Renal Replacement Therapy Intensity in Hyperammonemia

Who this might be right for
Acute Liver FailureAcute on Chronic Liver Failure (ACLF)Acute Kidney Injury+1 more
Hospital de Clinicas de Porto Alegre 152
Not applicableStudy completedNCT05687474
What this trial is testing

Baby Detect : Genomic Newborn Screening

Who this might be right for
Congenital Adrenal HyperplasiaFamilial Hyperinsulinemic Hypoglycemia 1Phosphoglucomutase 1 Deficiency+121 more
Centre Hospitalier Universitaire de Liege 6,824
Not applicableEnrolling By InvitationNCT03655223
What this trial is testing

Early Check: Expanded Screening in Newborns

Who this might be right for
Spinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more
RTI International 30,000
Large-scale testing (Phase 3)UnknownNCT00843921
What this trial is testing

N-Carbamylglutamate (Carbaglu) In The Treatment Of Hyperammonemia

Who this might be right for
Inborn Errors of Metabolism
Mendel Tuchman 52
Testing effectiveness (Phase 2)Study completedNCT01624311
What this trial is testing

Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants

Who this might be right for
Urea Cycle DisordersOrganic Acidemias
Uta Lichter-Konecki 5
Testing effectiveness (Phase 2)Study completedNCT00947544
What this trial is testing

Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders

Who this might be right for
Urea Cycle Disorders
Amgen 17
Not applicableStudy completedNCT03797222
What this trial is testing

Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome

Who this might be right for
Hyperinsulinism-Hyperammonemia Syndrome
Elizabeth A Rosenfeld 14
Not applicableEnrolling By InvitationNCT06041906
What this trial is testing

International Registry of Congenital Portosystemic Shunt (IRCPSS)

Who this might be right for
Congenital Portosystemic ShuntCPSS (Congenital Portosystemic Shunt)
Prof. Valérie Mc Lin 500
Testing effectiveness (Phase 2)Looking for participantsNCT06255782
What this trial is testing

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency

Who this might be right for
Ornithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseOrnithine Carbamoyltransferase Deficiency (Disorder)+1 more
iECURE, Inc. 8
Testing effectiveness (Phase 2)Study completedNCT01599286
What this trial is testing

Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia

Who this might be right for
Propionic Acidemia, Type I and/or Type IIMethylmalonic AcidemiaCarbamoyl-Phosphate Synthase I Deficiency Disease+1 more
Mendel Tuchman 35
Large-scale testing (Phase 3)Study completedNCT00947297
What this trial is testing

Study of the Safety of HPN (Hyperion)-100 for the Long-Term Treatment of Urea Cycle Disorders (Treat UCD)

Who this might be right for
Urea Cycle Disorders
Amgen 60
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