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Results for “Hypoxia Inducible Factor (HIF)”

47 trials

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Showing 20 of 47 results

Testing effectiveness (Phase 2)Study completedNCT03054337
What this trial is testing

Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD)

Who this might be right for
AnemiaNon-dialysis Dependent Chronic Kidney Disease
Akebia Therapeutics 51
Testing effectiveness (Phase 2)WithdrawnNCT00960921
What this trial is testing

Study of the Effects of Iron on Lung Blood Pressure at High Altitude

Who this might be right for
Hypertension, Pulmonary
University of Oxford
Large-scale testing (Phase 3)Active Not RecruitingNCT05899049
What this trial is testing

Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 249
Testing effectiveness (Phase 2)Ended earlyNCT03140722
What this trial is testing

Study to Evaluate Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) Who Are Hyporesponsive to Erythropoiesis Stimulating Agents

Who this might be right for
AnemiaDialysis-Dependent Chronic Kidney Disease
Akebia Therapeutics 2
Not applicableUnknownNCT00154973
What this trial is testing

Expression of Hypoxia-Inducible Factor-α in Oral Precancers and Cancers

Who this might be right for
Oral Cancer
National Taiwan University Hospital 60
Not applicableStudy completedNCT07025291
What this trial is testing

Assessment of Salivary Biomarker Levels in Individuals With Various Periodontal Diseases

Who this might be right for
Periodontal Diseases
Izmir Katip Celebi University 60
Not applicableStudy completedNCT02163473
What this trial is testing

Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock

Who this might be right for
Sepsis
University of Florida 63
Testing effectiveness (Phase 2)Active Not RecruitingNCT04489771
What this trial is testing

Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 154
Post-approval studies (Phase 4)UnknownNCT06115421
What this trial is testing

Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in the Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients

Who this might be right for
Anemia in Dialysis-dependent CKD Patients
Alexandria University 72
Large-scale testing (Phase 3)WithdrawnNCT03242967
What this trial is testing

Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD)

Who this might be right for
AnemiaDialysis-Dependent Chronic Kidney Disease
Akebia Therapeutics
Testing effectiveness (Phase 2)Study completedNCT02260193
What this trial is testing

16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis

Who this might be right for
AnemiaEnd Stage Renal Disease
Akebia Therapeutics 94
Not applicableStudy completedNCT00646555
What this trial is testing

Inflammatory Breast Cancer, Tumor Markers, and Factors Associated With Angiogenesis

Who this might be right for
Breast Neoplasms
National Cancer Institute (NCI) 300
Early research (Phase 1)Study completedNCT02564614
What this trial is testing

Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC)

Who this might be right for
Carcinoma, Hepatocellular
Hoffmann-La Roche 9
Testing effectiveness (Phase 2)Ended earlyNCT05935748
What this trial is testing

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

Who this might be right for
ccRCCClear Cell Renal Cell CarcinomaKidney Cancer+18 more
NiKang Therapeutics, Inc. 18
Large-scale testing (Phase 3)Study completedNCT02648347
What this trial is testing

Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Who this might be right for
AnemiaNon-Dialysis-Dependent Chronic Kidney Disease
Akebia Therapeutics 1,751
Large-scale testing (Phase 3)Active Not RecruitingNCT04736706
What this trial is testing

Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 1,653
Not applicableStudy completedNCT00952302
What this trial is testing

Study of the Effects of Iron Levels on the Lungs at High Altitude

Who this might be right for
Pulmonary HypertensionMountain Sickness
University of Oxford 33
Large-scale testing (Phase 3)Active Not RecruitingNCT04195750
What this trial is testing

Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 755
Large-scale testing (Phase 3)Study completedNCT02892149
What this trial is testing

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Who this might be right for
AnemiaDialysis-Dependent Chronic Kidney Disease
Akebia Therapeutics 3,554
Testing effectiveness (Phase 2)Ended earlyNCT05119335
What this trial is testing

NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Who this might be right for
ccRCCClear Cell Renal Cell CarcinomaKidney Cancer+14 more
NiKang Therapeutics, Inc. 120
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