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Results for “Hypoxia Inducible Factor (HIF)”

47 trials

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Showing 20 of 47 results

Testing effectiveness (Phase 2)Ended earlyNCT05935748
What this trial is testing

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

Who this might be right for
ccRCCClear Cell Renal Cell CarcinomaKidney Cancer+18 more
NiKang Therapeutics, Inc. 18
Large-scale testing (Phase 3)Active Not RecruitingNCT05239728
What this trial is testing

Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 1,800
Early research (Phase 1)Active Not RecruitingNCT04846920
What this trial is testing

Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 52
Large-scale testing (Phase 3)Active Not RecruitingNCT04195750
What this trial is testing

Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 755
Early research (Phase 1)Study completedNCT02299661
What this trial is testing

Pilot PK/PD Study of DS-1093a in Patients With Chronic Kidney Disease

Who this might be right for
Chronic Renal DiseaseRenal Anemia
Daiichi Sankyo 31
Testing effectiveness (Phase 2)Study completedNCT01906489
What this trial is testing

20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia

Who this might be right for
AnemiaChronic Kidney Disease
Akebia Therapeutics 210
Large-scale testing (Phase 3)Study completedNCT02648347
What this trial is testing

Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Who this might be right for
AnemiaNon-Dialysis-Dependent Chronic Kidney Disease
Akebia Therapeutics 1,751
Not applicableStudy completedNCT00646555
What this trial is testing

Inflammatory Breast Cancer, Tumor Markers, and Factors Associated With Angiogenesis

Who this might be right for
Breast Neoplasms
National Cancer Institute (NCI) 300
Testing effectiveness (Phase 2)WithdrawnNCT00960921
What this trial is testing

Study of the Effects of Iron on Lung Blood Pressure at High Altitude

Who this might be right for
Hypertension, Pulmonary
University of Oxford
Testing effectiveness (Phase 2)Active Not RecruitingNCT05468697
What this trial is testing

Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

Who this might be right for
Renal Cell Carcinoma
Merck Sharp & Dohme LLC 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT03634540
What this trial is testing

A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

Who this might be right for
Renal Cell Carcinoma (RCC)Clear Cell Renal Cell Carcinoma (ccRCC)Kidney Cancer+6 more
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 118
Large-scale testing (Phase 3)Active Not RecruitingNCT05899049
What this trial is testing

Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 249
Not applicableUnknownNCT00154973
What this trial is testing

Expression of Hypoxia-Inducible Factor-α in Oral Precancers and Cancers

Who this might be right for
Oral Cancer
National Taiwan University Hospital 60
Large-scale testing (Phase 3)WithdrawnNCT05082584
What this trial is testing

Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease Naive to Erythropoiesis-Stimulating Agents

Who this might be right for
Anemia of Chronic Kidney Disease
Akebia Therapeutics
Not applicableStudy completedNCT02163473
What this trial is testing

Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock

Who this might be right for
Sepsis
University of Florida 63
Post-approval studies (Phase 4)UnknownNCT06115421
What this trial is testing

Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in the Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients

Who this might be right for
Anemia in Dialysis-dependent CKD Patients
Alexandria University 72
Post-approval studies (Phase 4)Study completedNCT00880672
What this trial is testing

Effect of Dutasteride on HIF-1alpha and VEGF in the Prostate

Who this might be right for
Benign Prostatic Hyperplasia
Seoul National University Hospital 40
Early research (Phase 1)Study completedNCT03639155
What this trial is testing

A Study in Evaluating Bioequivalence Between Test and Reference Formulations of Vadadustat Tablets in Healthy Adults

Who this might be right for
Healthy
Akebia Therapeutics 50
Not applicableStudy completedNCT00952302
What this trial is testing

Study of the Effects of Iron Levels on the Lungs at High Altitude

Who this might be right for
Pulmonary HypertensionMountain Sickness
University of Oxford 33
Large-scale testing (Phase 3)Study completedNCT02865850
What this trial is testing

Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Who this might be right for
AnemiaDialysis-Dependent Chronic Kidney Disease
Akebia Therapeutics 369
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