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Results for “Leber Hereditary Optic Disease”

74 trials

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Showing 20 of 74 results

Not applicableLooking for participantsNCT03475173
What this trial is testing

New Non-invasive Modalities for Assessing Retinal Structure and Function

Who this might be right for
Ischemic Optic NeuropathyBranch Retinal Artery OcclusionHemianopia+2 more
Randy Kardon 500
Testing effectiveness (Phase 2)UnknownNCT03872479
What this trial is testing

Single Ascending Dose Study in Participants With LCA10

Who this might be right for
Leber Congenital Amaurosis 10Inherited Retinal DystrophiesEye Diseases, Hereditary+4 more
Editas Medicine, Inc. 34
Not applicableStudy completedNCT05555784
What this trial is testing

Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Argo Sante 12
Large-scale testing (Phase 3)UnknownNCT04855045
What this trial is testing

An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene.

Who this might be right for
Leber Congenital Amaurosis 10BlindnessLeber Congenital Amaurosis+8 more
ProQR Therapeutics 15
Large-scale testing (Phase 3)Study completedNCT02652767
What this trial is testing

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation

Who this might be right for
Optic, Atrophy, Hereditary, Leber
GenSight Biologics 39
Testing effectiveness (Phase 2)Ended earlyNCT05820152
What this trial is testing

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations

Who this might be right for
Leber Hereditary Optic Neuropathy (LHON)
Neurophth Therapeutics Inc 11
Not applicableEnded earlyNCT02982499
What this trial is testing

Biomechanics of Optic Neuropathy

Who this might be right for
Optic Neuropathy
University of Miami 10
Testing effectiveness (Phase 2)Active Not RecruitingNCT05203939
What this trial is testing

Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis

Who this might be right for
Retinitis PigmentosaLeber Congenital Amaurosis
Ocugen 22
Not applicableStudy completedNCT01421381
What this trial is testing

RHODOS Follow-up Single-visit Study

Who this might be right for
Leber's Hereditary Optic Neuropathy
Santhera Pharmaceuticals 60
Not applicableStudy completedNCT02946879
What this trial is testing

Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)

Who this might be right for
Leber Congenital Amaurosis (LCA)Eye DiseasesEye Diseases, Hereditary+1 more
MeiraGTx UK II Ltd 15
Not applicableLooking for participantsNCT01694940
What this trial is testing

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

Who this might be right for
Mitochondrial DisordersMitochondrial Genetic DisordersMitochondrial Diseases+2 more
Columbia University 1,000
Not applicableStudy completedNCT01267422
What this trial is testing

Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON)

Who this might be right for
Leber Hereditary Optic Neuropathy
Bin Li 9
Not applicableActive Not RecruitingNCT03602820
What this trial is testing

Long-term Follow-up Study in Subjects Who Received Voretigene Neparvovec-rzyl (AAV2-hRPE65v2)

Who this might be right for
Inherited Retinal Dystrophy Due to RPE65 Mutations
Genentech, Inc. 41
Testing effectiveness (Phase 2)Study completedNCT00747487
What this trial is testing

Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy

Who this might be right for
Leber's Hereditary Optic Neuropathy
Santhera Pharmaceuticals 85
Testing effectiveness (Phase 2)Active Not RecruitingNCT03920007
What this trial is testing

Study of Subretinally Injected ATSN-101 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D

Who this might be right for
Leber Congenital AmaurosisLCALCA1
Atsena Therapeutics Inc. 15
Early research (Phase 1)Study completedNCT01521793
What this trial is testing

Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)

Who this might be right for
LCA (Leber Congenital Amaurosis)RP (Retinitis Pigmentosa)
QLT Inc. 27
Not applicableStudy completedNCT04909398
What this trial is testing

Pupil Dynamics and Color Vision for the Detection of Eye Diseases

Who this might be right for
Retinitis PigmentosaLeber's Hereditary Optic NeuropathyStargardt Disease
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts 60
Not applicableStudy completedNCT02771379
What this trial is testing

Post Authorisation Safety Study With Raxone in LHON Patients

Who this might be right for
Leber's Hereditary Optic Neuropathy (LHON)
Santhera Pharmaceuticals 229
Very early researchUnknownNCT03566147
What this trial is testing

Treatment of RP and LCA by Primary RPE Transplantation

Who this might be right for
Leber Congenital Amaurosis, Retinitis Pigmentosa
Eyecure Therapeutics Inc. 30
Testing effectiveness (Phase 2)Looking for participantsNCT05906953
What this trial is testing

Safety and Efficacy Trial of HG004 for Leber Congenital Amaurosis Related to Rpe65 Gene Mutations (STAR)

Who this might be right for
Leber Congenital AmaurosisInherited Retinal Diseases Caused by RPE65 Mutations
HuidaGene Therapeutics Co., Ltd. 20
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