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Results for “Mitochondrial DNA Mutation”

22 trials

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Enrolling by Invitation

Showing 20 of 22 results

Early research (Phase 1)Study completedNCT02161380
What this trial is testing

Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy

Who this might be right for
Leber's Hereditary Optic Neuropathy
Byron Lam 28
Testing effectiveness (Phase 2)Temporarily pausedNCT04846036
What this trial is testing

The KHENERGYC Study

Who this might be right for
Mitochondrial DiseasesMitochondrial DNA tRNALeu(UUR) m.3243A<G MutationMELAS+1 more
Khondrion BV 24
Large-scale testing (Phase 3)Study completedNCT05162768
What this trial is testing

Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)

Who this might be right for
Mitochondrial MyopathiesMitochondrial PathologyMitochondrial DNA Mutation+5 more
Stealth BioTherapeutics Inc. 102
Not applicableUnknownNCT05196243
What this trial is testing

Multimodal Imaging Based on Pathological and Genomic Characteristics

Who this might be right for
Mitochondrial DNA MutationEndoscopy
Affiliated Hospital to Academy of Military Medical Sciences 200
Not applicableUnknownNCT00831948
What this trial is testing

Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.

Who this might be right for
Mitochondrial DiseasesDiagnosisDNA Mutations
Centre Hospitalier Universitaire de Nice 20
Large-scale testing (Phase 3)Looking for participantsNCT06451757
What this trial is testing

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

Who this might be right for
Mitochondrial DiseasesMaternally Inherited Diabetes and Deafness (MIDD)Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)+1 more
Khondrion BV 220
Not applicableLooking for participantsNCT05199740
What this trial is testing

MtDNA Mutation Load Analysis in Mesoangioblasts

Who this might be right for
Mitochondrial Myopathies
Maastricht University 30
Early research (Phase 1)Study completedNCT03056209
What this trial is testing

Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers

Who this might be right for
MELAS SyndromeMitochondrial Respiratory Chain Deficiencies
Yungjin Pharm. Co., Ltd. 60
Early research (Phase 1)Study completedNCT02544217
What this trial is testing

A Dose-escalating Clinical Trial With KH176

Who this might be right for
MELASLHONLeigh Syndrome+2 more
Khondrion BV 32
Testing effectiveness (Phase 2)Study completedNCT02909400
What this trial is testing

The KHENERGY Study

Who this might be right for
Mitochondrial DiseasesMitochondrial MyopathiesMitochondrial Encephalomyopathies+2 more
Khondrion BV 20
Early research (Phase 1)WithdrawnNCT04548843
What this trial is testing

A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion

Who this might be right for
Primary Mitochondrial Diseases
Minovia Therapeutics Ltd.
Testing effectiveness (Phase 2)Ended earlyNCT01074359
What this trial is testing

Safety and Efficacy Study of A0001 in Patients With the A3243G Mitochondrial DNA Point Mutation

Who this might be right for
Neuromuscular Disease
Penwest Pharmaceuticals Co. 30
Not applicableEnrolling By InvitationNCT06450964
What this trial is testing

Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic Diseases

Who this might be right for
Mitochondrial Diseases
Anhui Medical University 600
Not applicableLooking for participantsNCT01532791
What this trial is testing

Natural History Study - Mitochondrial Disease

Who this might be right for
MELAS or m.3243 A>G Mitochondrial DNA Mutation Carrier
Columbia University 300
Not applicableStudy completedNCT05012358
What this trial is testing

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Who this might be right for
Mitochondrial MyopathiesMitochondrial DNA MutationMitochondrial Diseases+2 more
Mayo Clinic 9
Testing effectiveness (Phase 2)Study completedNCT04604548
What this trial is testing

The KHENEREXT Study

Who this might be right for
Mitochondrial DiseasesMitochondrial DNA tRNALeu(UUR) m.3243A<G MutationMaternally Inherited Diabetes and Deafness (MIDD)+2 more
Khondrion BV 11
Testing effectiveness (Phase 2)Study completedNCT01854294
What this trial is testing

GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)

Who this might be right for
Amyotrophic Lateral Sclerosis
Genervon Biopharmaceuticals, LLC 12
Not applicableLooking for participantsNCT06682819
What this trial is testing

Metabolomics Analysis According to the Retinal Nerve Fiber Layer in Patients With NOHL Mutations (MétabOCT)

Who this might be right for
Healthy SubjectsLeber Hereditary Optic Neuropathy
Hôpital Necker-Enfants Malades 90
Not applicableLooking for participantsNCT01793168
What this trial is testing

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Who this might be right for
Rare DisordersUndiagnosed DisordersDisorders of Unknown Prevalence+340 more
Sanford Health 20,000
Not applicableStudy completedNCT00406445
What this trial is testing

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Who this might be right for
Mitochondrial DisordersLi-Fraumeni SyndromeCarriers of p53 Mutation
National Heart, Lung, and Blood Institute (NHLBI) 82
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