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Results for “OPSCC”

29 trials

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Showing 20 of 29 results

Not applicableUnknownNCT02663583
What this trial is testing

Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell

Who this might be right for
Cancer of the MouthOropharynx Squamous Cell Carcinoma
M.D. Anderson Cancer Center 44
Not applicableEnded earlyNCT01891695
What this trial is testing

OPSCC N0 Nodal Control With Reduced IMRT

Who this might be right for
Oropharyngeal Squamous Cell Carcinoma (OPSCCA)HPV (Human Papillomavirus)-Associated
Paul W. Read, MD 1
Testing effectiveness (Phase 2)Study completedNCT03077243
What this trial is testing

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

Who this might be right for
Carcinoma, Squamous CellHead and Neck NeoplasmsOropharyngeal Neoplasms
UNC Lineberger Comprehensive Cancer Center 195
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07513389
What this trial is testing

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

Who this might be right for
Squamous Cell CarcinomaHuman Papilloma Virus (HPV)Oropharyngeal Squamous Cell Carcinoma (OPSCC)
Medical University of South Carolina 36
Testing effectiveness (Phase 2)Active Not RecruitingNCT05232851
What this trial is testing

A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer

Who this might be right for
Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Human Papillomavirus-Related CarcinomaLocally Advanced Oropharyngeal Carcinoma+2 more
Mayo Clinic 20
Not applicableUnknownNCT04867330
What this trial is testing

Toripalimab Based Induction Chemotherapy Followed by De-escalation Protocols in HPV-related OPSCC

Who this might be right for
Oropharyngeal CarcinomaImmune Checkpoint InhibitorDe-escalation
Fudan University 46
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07418034
What this trial is testing

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)

Who this might be right for
Head and Neck CancerHead and Neck Squamous Cell CancerHead and Neck Squamous Cell Carcinoma+11 more
University of Maryland, Baltimore 132
Large-scale testing (Phase 3)Active Not RecruitingNCT03811015
What this trial is testing

Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

Who this might be right for
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
National Cancer Institute (NCI) 636
Testing effectiveness (Phase 2)Ended earlyNCT04106362
What this trial is testing

Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma

Who this might be right for
Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8KRAS Protein Variant+2 more
Jonsson Comprehensive Cancer Center 1
Testing effectiveness (Phase 2)Ended earlyNCT03258008
What this trial is testing

Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

Who this might be right for
Malignant Neoplasms of Ill-defined Secondary and Unspecified SitesMalignant Neoplasms of Lip Oral Cavity and PharynxOropharyngeal Cancer
M.D. Anderson Cancer Center 3
Testing effectiveness (Phase 2)Active Not RecruitingNCT03799445
What this trial is testing

Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma

Who this might be right for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma+8 more
M.D. Anderson Cancer Center
Testing effectiveness (Phase 2)Study completedNCT03715946
What this trial is testing

Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer

Who this might be right for
Carcinoma, Squamous Cell of Head and NeckOropharynx Squamous Cell Carcinoma
Robert L. Ferris, MD, PhD 40
Not applicableLooking for participantsNCT06174428
What this trial is testing

Validity of Viome's Oral/throat Cancer Test

Who this might be right for
Oral and Throat CancerOropharyngeal Squamous Cell CarcinomaOral Squamous Cell Carcinoma
Viome 1,000
Early research (Phase 1)Study completedNCT01721525
What this trial is testing

Induction Chemotherapy With Afatinib, Ribavirin, and Weekly Carboplatin/Paclitaxel for Stage IVA/IVB HPV Associated Oropharynx Squamous Cell Cancer (OPSCC)

Who this might be right for
Head and Neck CancerSquamous Cell Cancer
Memorial Sloan Kettering Cancer Center 10
Not applicableLooking for participantsNCT07133958
What this trial is testing

A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC

Who this might be right for
Oral Squamous Cell Carcinoma (OSCC)Oropharyngeal Squamous Cell Carcinoma (SCC)
Zhujiang Hospital 35
Not applicableUnknownNCT05065086
What this trial is testing

Single Modality Trans Oral Robotic Surgery for Primary Oropharyngeal Cancer: Exploring the Impact of Surgical Margins on Local Disease Recurrence

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Royal Marsden NHS Foundation Trust 500
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06759155
What this trial is testing

Phase II Clinical Trial of De-Intensified Therapy in Human Papilloma Virus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma

Who this might be right for
OPSCCOropharyngeal Squamous Cell Carcinoma (SCC)HPV Associated Cancers
University of Vermont Medical Center 20
Not applicableActive Not RecruitingNCT06592716
What this trial is testing

Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?

Who this might be right for
Oropharynx CancerOropharynx Cancer, MetastaticOropharynx Cancer, Recurrent+2 more
Rigshospitalet, Denmark 200
Not applicableStudy completedNCT06771674
What this trial is testing

Real-world Study of First Line Pembrolizumab- or Nivolumab-treated HPV-positive Recurrent/Metastatic Oropharyngeal Squamous Cell Carcinoma

Who this might be right for
Oropharyngeal Squamous Cell Carcinoma
Hookipa Biotech GmbH 662
Testing effectiveness (Phase 2)Ended earlyNCT04916002
What this trial is testing

A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer

Who this might be right for
Merkel Cell CarcinomaCutaneous Squamous Cell CarcinomaBasal Cell Carcinoma+3 more
Regeneron Pharmaceuticals 77
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