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Results for “PALB2 Gene Mutation”

36 trials

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Showing 20 of 36 results

Not applicableLooking for participantsNCT01689584
What this trial is testing

COsegregation of VARiants in Panel of Genes

Who this might be right for
Gene Mutation-Related CancerGenetic Predisposition
Institut Curie 3,500
Early research (Phase 1)Looking for participantsNCT06488378
What this trial is testing

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

Who this might be right for
Breast CancerPALB2-Mutated Breast CarcinomaHER2-negative Breast Cancer+2 more
Dana-Farber Cancer Institute 20
Early research (Phase 1)Looking for participantsNCT06177171
What this trial is testing

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

Who this might be right for
BRCA1 MutationBRCA2 MutationBRCA Mutation+3 more
Pamela Munster 18
Not applicableActive Not RecruitingNCT02760849
What this trial is testing

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

Who this might be right for
Deleterious BARD1 Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+11 more
M.D. Anderson Cancer Center 374
Early research (Phase 1)Active Not RecruitingNCT05358639
What this trial is testing

Combination of Olaparib and Navitoclax in Women with HGSC and TNBC

Who this might be right for
High Grade Serous CarcinomaTriple Negative Breast CancerOvarian Cancer
Sunnybrook Health Sciences Centre 36
Not applicableLooking for participantsNCT04960839
What this trial is testing

Prophylactic Irradiation to the Contralateral Breast for BCAs Patients

Who this might be right for
Breast Cancer
Second Affiliated Hospital, School of Medicine, Zhejiang University 323
Not applicableLooking for participantsNCT05420064
What this trial is testing

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Who this might be right for
BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more
Memorial Sloan Kettering Cancer Center 1,000
Early research (Phase 1)Looking for participantsNCT04890613
What this trial is testing

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Who this might be right for
Advanced Solid Tumor
Senhwa Biosciences, Inc. 52
Testing effectiveness (Phase 2)Looking for participantsNCT04858334
What this trial is testing

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Who this might be right for
Pancreatic Acinar Cell CarcinomaPancreatic Adenosquamous CarcinomaPancreatic Squamous Cell Carcinoma+4 more
National Cancer Institute (NCI) 152
Testing effectiveness (Phase 2)Active Not RecruitingNCT06033092
What this trial is testing

Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion

Who this might be right for
BRCA MutationPALB2 Gene MutationDuctal Carcinoma in Situ+6 more
European Institute of Oncology 200
Testing effectiveness (Phase 2)Ended earlyNCT05169437
What this trial is testing

Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors

Who this might be right for
Solid TumorBreast TumorColon Tumor, Malignant+9 more
Tempus AI 22
Early research (Phase 1)Not Yet RecruitingNCT06614751
What this trial is testing

A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway

Who this might be right for
Solid CancersBRCA MutationHRD Cancer+8 more
Danatlas Pharmaceuticals Co., Ltd 112
Testing effectiveness (Phase 2)Study completedNCT03377556
What this trial is testing

Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer

Who this might be right for
ATM Gene MutationATR Gene MutationBARD1 Gene Mutation+18 more
SWOG Cancer Research Network 51
Testing effectiveness (Phase 2)Active Not RecruitingNCT01585805
What this trial is testing

Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

Who this might be right for
Locally Advanced Pancreatic AdenocarcinomaMetastatic Pancreatic AdenocarcinomaStage III Pancreatic Cancer AJCC v8+1 more
National Cancer Institute (NCI) 88
Testing effectiveness (Phase 2)Active Not RecruitingNCT02286687
What this trial is testing

Talazoparib in Treating Patients With Recurrent, Refractory, Advanced, or Metastatic Cancers and Alterations in the BRCA Genes

Who this might be right for
Advanced Malignant NeoplasmATM Gene MutationBRCA1 Gene Mutation+5 more
M.D. Anderson Cancer Center 150
Not applicableNot Yet RecruitingNCT06726330
What this trial is testing

Risk-reducing Strategies, Including Fimbriectomy, in Women With a Germline Mutation Predisposing to Ovarian or Pelvic Cancer

Who this might be right for
Tubo-ovarian CarcinomaHigh-grade Serous CarcinomaPrimary Peritoneal Carcinoma Stage III+2 more
Centre Oscar Lambret 1,100
Early research (Phase 1)Looking for participantsNCT05787587
What this trial is testing

PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsBreast CancerOvarian Cancer+6 more
IDEAYA Biosciences 216
Large-scale testing (Phase 3)Looking for participantsNCT06783140
What this trial is testing

Study of NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Pancreatic Cancer

Who this might be right for
Pancreatic Cancer, Advanced or MetastaticBRCA1/2 MutationPALB2 Gene Mutation
University Health Network, Toronto 10
Testing effectiveness (Phase 2)Study completedNCT02401347
What this trial is testing

Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors

Who this might be right for
Advanced Breast CancerHER2/Neu NegativeTriple-Negative Breast Cancer
Melinda Telli 21
Large-scale testing (Phase 3)Looking for participantsNCT02000089
What this trial is testing

The Cancer of the Pancreas Screening-5 CAPS5)Study

Who this might be right for
Pancreas CancerPeutz-Jeghers Syndrome (PJS)Gene Mutation+2 more
Johns Hopkins University 9,000
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