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Results for “PALB2 Gene Mutation”

36 trials

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Showing 20 of 36 results

Testing effectiveness (Phase 2)WithdrawnNCT04756765
What this trial is testing

Talazoparib Monotherapy in PALB2 Mutation Associated Advanced Breast Cancer

Who this might be right for
Breast CancerAdvanced Breast Cancer
Stanford University
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Early research (Phase 1)Not Yet RecruitingNCT06614751
What this trial is testing

A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway

Who this might be right for
Solid CancersBRCA MutationHRD Cancer+8 more
Danatlas Pharmaceuticals Co., Ltd 112
Testing effectiveness (Phase 2)Active Not RecruitingNCT06033092
What this trial is testing

Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion

Who this might be right for
BRCA MutationPALB2 Gene MutationDuctal Carcinoma in Situ+6 more
European Institute of Oncology 200
Early research (Phase 1)Looking for participantsNCT04890613
What this trial is testing

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Who this might be right for
Advanced Solid Tumor
Senhwa Biosciences, Inc. 52
Not applicableTemporarily pausedNCT02993068
What this trial is testing

Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)

Who this might be right for
BARD1 Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+12 more
M.D. Anderson Cancer Center 5,200
Testing effectiveness (Phase 2)Active Not RecruitingNCT01585805
What this trial is testing

Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

Who this might be right for
Locally Advanced Pancreatic AdenocarcinomaMetastatic Pancreatic AdenocarcinomaStage III Pancreatic Cancer AJCC v8+1 more
National Cancer Institute (NCI) 83
Testing effectiveness (Phase 2)Ended earlyNCT03140670
What this trial is testing

Maintenance Rucaparib in BRCA1, BRCA2 or PALB2 Mutated Pancreatic Cancer That Has Not Progressed on Platinum-based Therapy

Who this might be right for
Pancreatic Cancer
Abramson Cancer Center at Penn Medicine 46
Not applicableActive Not RecruitingNCT05692596
What this trial is testing

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

Who this might be right for
Pancreatic Ductal AdenocarcinomaPancreatic CystChronic Pancreatitis+10 more
H. Lee Moffitt Cancer Center and Research Institute 317
Not applicableLooking for participantsNCT04960839
What this trial is testing

Prophylactic Irradiation to the Contralateral Breast for BCAs Patients

Who this might be right for
Breast Cancer
Second Affiliated Hospital, School of Medicine, Zhejiang University 323
Testing effectiveness (Phase 2)Study completedNCT02401347
What this trial is testing

Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors

Who this might be right for
Advanced Breast CancerHER2/Neu NegativeTriple-Negative Breast Cancer
Melinda Telli 21
Testing effectiveness (Phase 2)Study completedNCT02873975
What this trial is testing

LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency

Who this might be right for
Advanced Cancers
Dana-Farber Cancer Institute 27
Testing effectiveness (Phase 2)WithdrawnNCT06392841
What this trial is testing

Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations

Who this might be right for
Metastatic Hormone-sensitive Prostate Cancer (mHSPC)Deleterious HRR Gene MutationBRCA1 Gene Mutation+7 more
Qian Qin
Not applicableLooking for participantsNCT05420064
What this trial is testing

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Who this might be right for
BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more
Memorial Sloan Kettering Cancer Center 1,000
Not applicableLooking for participantsNCT05097274
What this trial is testing

The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.

Who this might be right for
Prostate CancerBRCA MutationMismatch Repair Gene Mutation+4 more
Institute of Cancer Research, United Kingdom 50
Not applicableActive Not RecruitingNCT02760849
What this trial is testing

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

Who this might be right for
Deleterious BARD1 Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+11 more
M.D. Anderson Cancer Center 374
Not applicableStudy completedNCT03075735
What this trial is testing

Prospective Multicentre Cohort Study PROREPAIR-B (mCRPC)

Who this might be right for
Prostate Cancer
Centro Nacional de Investigaciones Oncologicas CARLOS III 408
Large-scale testing (Phase 3)Looking for participantsNCT06783140
What this trial is testing

Study of NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Pancreatic Cancer

Who this might be right for
Pancreatic Cancer, Advanced or MetastaticBRCA1/2 MutationPALB2 Gene Mutation
University Health Network, Toronto 10
Testing effectiveness (Phase 2)Active Not RecruitingNCT04584255
What this trial is testing

Niraparib + Dostarlimab In BRCA Mutated Breast Cancer

Who this might be right for
Stage I Breast CancerStage II Breast CancerStage III Breast Cancer+5 more
Dana-Farber Cancer Institute 62
Early research (Phase 1)Looking for participantsNCT05694715
What this trial is testing

Combination Therapy in Cancers With Mutations in DNA Repair Genes

Who this might be right for
Metastatic Solid TumorBRCA1 MutationBRCA2 Mutation+2 more
University of California, San Francisco 24
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