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Results for “Parkinson Disease, Secondary”

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Large-scale testing (Phase 3)Study completedNCT02555657
What this trial is testing

Study of Single Agent Pembrolizumab (MK-3475) Versus Single Agent Chemotherapy for Metastatic Triple Negative Breast Cancer (MK-3475-119/KEYNOTE-119)

Who this might be right for
Metastatic Triple Negative Breast Cancer
Merck Sharp & Dohme LLC 622
Not applicableStudy completedNCT04858893
What this trial is testing

Application of Machine Learning Method in Validation of Screening Cognitive Test for Parkinsonisms

Who this might be right for
Primary ParkinsonismSecondary Vascular Parkinson DiseaseMultiple System Atrophy+1 more
Ospedale Generale Di Zona Moriggia-Pelascini 562
Early research (Phase 1)Active Not RecruitingNCT05853367
What this trial is testing

Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)

Who this might be right for
Metastatic Solid TumorsAdvanced Solid Tumors
Merck Sharp & Dohme LLC 95
Large-scale testing (Phase 3)Ended earlyNCT04246177
What this trial is testing

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Who this might be right for
Carcinoma, Hepatocellular
Merck Sharp & Dohme LLC 480
Large-scale testing (Phase 3)Looking for participantsNCT06345729
What this trial is testing

Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 600
Not applicableStudy completedNCT05388526
What this trial is testing

Frailty and Cognitive Function in Parkinson's Disease.

Who this might be right for
Parkinson Disease
University of Oviedo 100
Testing effectiveness (Phase 2)Study completedNCT03993353
What this trial is testing

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

Who this might be right for
Head and Neck CancerHead and Neck Squamous Cell CarcinomaHead and Neck Carcinoma+9 more
University of California, San Diego 7
Large-scale testing (Phase 3)Study completedNCT02702401
What this trial is testing

Study of Pembrolizumab (MK-3475) vs. Best Supportive Care in Participants With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-240/KEYNOTE-240)

Who this might be right for
Hepatocellular Carcinoma
Merck Sharp & Dohme LLC 413
Large-scale testing (Phase 3)Study completedNCT02564263
What this trial is testing

Study of Pembrolizumab (MK-3475) Versus Investigator's Choice Standard Therapy for Participants With Advanced Esophageal/ Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)

Who this might be right for
Esophageal CarcinomaEsophagogastric Junction Carcinoma
Merck Sharp & Dohme LLC 628
Large-scale testing (Phase 3)Study completedNCT04776148
What this trial is testing

Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017)

Who this might be right for
Colorectal Neoplasms
Merck Sharp & Dohme LLC 563
Large-scale testing (Phase 3)Study completedNCT04676412
What this trial is testing

Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 107
Not applicableUnknownNCT02588924
What this trial is testing

Study on the Relationship Between Environmental and Occupational Exposure to Metals and Parkinson's Disease

Who this might be right for
Parkinson Disease, Secondary
University of Campania Luigi Vanvitelli 100
Large-scale testing (Phase 3)Active Not RecruitingNCT05152147
What this trial is testing

Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Who this might be right for
Gastric NeoplasmsGastroesophageal AdenocarcinomaEsophageal Adenocarcinoma
Jazz Pharmaceuticals 920
Large-scale testing (Phase 3)Ended earlyNCT04738487
What this trial is testing

Coformulation of Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab (MK-3475) Monotherapy for Programmed Cell Death 1 Ligand 1 (PD-L1) Positive Metastatic Non-Small Cell Lung Cancer (MK-7684A-003, KEYVIBE-003)

Who this might be right for
Lung NeoplasmsNon-Small-Cell Lung Carcinoma
Merck Sharp & Dohme LLC 1,264
Testing effectiveness (Phase 2)Study completedNCT02447003
What this trial is testing

Study of Pembrolizumab (MK-3475) Monotherapy for Metastatic Triple-Negative Breast Cancer (MK-3475-086/KEYNOTE-086)

Who this might be right for
Breast Cancer
Merck Sharp & Dohme LLC 254
Early research (Phase 1)Study completedNCT02027961
What this trial is testing

Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone

Who this might be right for
Melanoma
MedImmune LLC 68
Large-scale testing (Phase 3)Study completedNCT04191096
What this trial is testing

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)

Who this might be right for
Metastatic Hormone-Sensitive Prostate Cancer
Merck Sharp & Dohme LLC 1,251
Testing effectiveness (Phase 2)Looking for participantsNCT06469944
What this trial is testing

Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

Who this might be right for
Gastroesophageal JunctionGastroesophageal AdenocarcinomaEsophageal Neoplasms+1 more
Merck Sharp & Dohme LLC 160
Testing effectiveness (Phase 2)Study completedNCT00761137
What this trial is testing

Safety and Efficacy Study of NH004 Films for Relief of Sialorrhea Symptoms in Parkinson's Disease Patients

Who this might be right for
Sialorrhea Secondary to Parkinson's Disease
NeuroHealing Pharmaceuticals Inc. 19
Testing effectiveness (Phase 2)Study completedNCT04700072
What this trial is testing

Substudy 02D: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Melanoma Brain Metastasis (MK-3475-02D/KEYMAKER-U02)

Who this might be right for
Melanoma
Merck Sharp & Dohme LLC 56
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