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Results for “Protein Kinase Inhibitors”

108 trials

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Showing 20 of 108 results

Not applicableEnded earlyNCT02455024
What this trial is testing

An Observational Registry to Evaluate the Incidence of and Risk Factors for Vascular Occlusive Events Associated With ICLUSIG®

Who this might be right for
Myeloid Leukemia, Chronic-Phase, Accelerated-Phase, Blast-Phase, Ph+ALL
Ariad Pharmaceuticals 3
Early research (Phase 1)Study completedNCT00443976
What this trial is testing

Aurora Kinase Inhibitor AT9283 in Treating Patients With Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma

Who this might be right for
Non-Hodgkins LymphomaUnspecified Adult Solid Tumor, Protocol Specific
NCIC Clinical Trials Group 35
Not applicableEnded earlyNCT02071719
What this trial is testing

Prediction of Response to Kinase Inhibitors Based on Protein Phosphorylation Profiles in Tumor Tissue From Advanced Renal Cell Cancer Patients

Who this might be right for
Renal Cell Cancer
M. Labots 6
Large-scale testing (Phase 3)Looking for participantsNCT06988475
What this trial is testing

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

Who this might be right for
Solid TumourHaematological MalignancyMalignant Neoplasm+8 more
Cancer Research UK 30
Early research (Phase 1)Ended earlyNCT03116971
What this trial is testing

Phase Ib/II Study of M3814 With Etoposide and Cisplatin in Small Cell Lung Cancer (SCLC) Extensive Disease (ED)

Who this might be right for
Small Cell Lung Cancer
EMD Serono Research & Development Institute, Inc. 2
Testing effectiveness (Phase 2)Study completedNCT01229150
What this trial is testing

Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva...

Who this might be right for
Non Small Cell Lung Carcinoma
National Cancer Institute (NCI) 89
Testing effectiveness (Phase 2)WithdrawnNCT04953052
What this trial is testing

Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care.

Who this might be right for
Acute Respiratory Distress SyndromeCOVID-19 Acute Respiratory Distress SyndromeCovid19+2 more
Exvastat Ltd.
Early research (Phase 1)Study completedNCT05002140
What this trial is testing

Trial of XRD-0394, a Kinase Inhibitor, in Combination With Palliative Radiotherapy in Advanced Cancer Patients

Who this might be right for
MetastasisLocally Advanced Solid TumorRecurrent Cancer
XRad Therapeutics Inc 12
Testing effectiveness (Phase 2)Study completedNCT02362035
What this trial is testing

ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies

Who this might be right for
Follicular Lymphoma (FL)CLLSmall Lymphocytic Lymphoma (SLL)+10 more
Acerta Pharma BV 161
Large-scale testing (Phase 3)Looking for participantsNCT01804686
What this trial is testing

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaMantle Cell Lymphoma+4 more
Janssen Research & Development, LLC 700
Large-scale testing (Phase 3)Not Yet RecruitingNCT07440290
What this trial is testing

DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

Who this might be right for
Haematological MalignancyMalignant NeoplasmLymphoproliferative Disorders+16 more
Cancer Research UK 30
Testing effectiveness (Phase 2)Ended earlyNCT03037645
What this trial is testing

Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaLymphoplasmacytoid Lymphoma+5 more
Sunesis Pharmaceuticals 39
Testing effectiveness (Phase 2)Study completedNCT01750281
What this trial is testing

Assess Efficacy and Safety of AZD6244 in Combination With Docetaxel in Patients Receiving Second Line Non Small Cell Lung Cancer Treatment.

Who this might be right for
Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV
AstraZeneca 212
Not applicableUnknownNCT05430126
What this trial is testing

Hepatotoxicity Related to Protein Kinase Inhibitors

Who this might be right for
Cancer
Central South University 600,000
Large-scale testing (Phase 3)Looking for participantsNCT07185997
What this trial is testing

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

Who this might be right for
Non-Small-Cell Lung CancerMetastatic Non-Small-Cell Lung CancerAdvanced Non-Small-Cell Lung Cancer+3 more
ArriVent BioPharma, Inc.
Early research (Phase 1)WithdrawnNCT04355039
What this trial is testing

INCB053914 and Pomalidomide With Dexamethasone for Relapsed and/or Refractory Multiple Myeloma

Who this might be right for
Refractory Multiple MyelomaRelapse Multiple Myeloma
Medical College of Wisconsin
Testing effectiveness (Phase 2)Study completedNCT04116437
What this trial is testing

Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment

Who this might be right for
Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaMantle Cell LymphomaMarginal Zone Lymphoma+1 more
BeiGene 96
Testing effectiveness (Phase 2)UnknownNCT01764087
What this trial is testing

KX2-391 With Paclitaxel in Patients With Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol SpecificGastric CancerBreast Cancer
Hanmi Pharmaceutical Company Limited 60
Testing effectiveness (Phase 2)Ended earlyNCT04575610
What this trial is testing

IRAK4 Inhibition in Treatment of COVID-19 With ARDS (I-RAMIC)

Who this might be right for
COVID-19
Yale University 7
Early research (Phase 1)Study completedNCT02820961
What this trial is testing

Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer

Who this might be right for
Breast CancerEstrogen Receptor Positive Breast Cancer
Syndax Pharmaceuticals 61
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