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Results for “Severe Functional Impairment”

166 trials

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Showing 20 of 166 results

Early research (Phase 1)Ended earlyNCT02050815
What this trial is testing

MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function

Who this might be right for
Hepatic Impairment
Array Biopharma, now a wholly owned subsidiary of Pfizer 27
Early research (Phase 1)Study completedNCT00824590
What this trial is testing

A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function

Who this might be right for
Alzheimer's DiseaseHuntington's Disease
Pfizer 20
Not applicableStudy completedNCT01435694
What this trial is testing

Robot-assisted Gait Training in Multiple Sclerosis Subjects

Who this might be right for
Multiple Sclerosis
University Hospital of Ferrara 60
Early research (Phase 1)Ended earlyNCT04678505
What this trial is testing

Study of a Single Intravenous (IV) Dose of MK-3402 in Participants With Impaired Renal Function and in Healthy Controls (MK-3402-004)

Who this might be right for
Renal Impairment
Merck Sharp & Dohme LLC 9
Early research (Phase 1)UnknownNCT02840812
What this trial is testing

Pharmacokinetics Study of Nemonoxacin Malate Capsules in Subjects With Severe Impaired Renal Function

Who this might be right for
Kidney Dysfunction
Zhejiang Medicine Co., Ltd. 24
Early research (Phase 1)Study completedNCT05882032
What this trial is testing

LY3502970 in Participants With Impaired and Normal Liver Function

Who this might be right for
HealthyHepatic Insufficiency
Eli Lilly and Company 29
Early research (Phase 1)Study completedNCT06916078
What this trial is testing

Lepodisiran (LY3819469) in Participants With Normal, Mild, Moderate, or Severe Liver Function

Who this might be right for
Liver DysfunctionHealthy
Eli Lilly and Company 30
Large-scale testing (Phase 3)Study completedNCT00702715
What this trial is testing

Comparison of 4.0 mg/kg Sugammadex at 1-2 Post Tetanic Counts (PTC) in Renal or Control Patients (19.4.328)(P05769)

Who this might be right for
Anesthesia
Merck Sharp & Dohme LLC 69
Not applicableLooking for participantsNCT07121660
What this trial is testing

Post-operative Changes Study

Who this might be right for
Post-operative Functional DeclineSevere Neurological Impairment
University of British Columbia 17
Early research (Phase 1)Study completedNCT01766154
What this trial is testing

Pharmacokinetic Evaluation of Tirofiban Using a Single High-Dose Bolus In Subjects With Varying Degrees of Renal Function

Who this might be right for
Renal Insufficiency
Medicure 25
Early research (Phase 1)Study completedNCT05940402
What this trial is testing

Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function

Who this might be right for
Renal Impairment
AbbVie 58
Early research (Phase 1)Study completedNCT02138162
What this trial is testing

Investigate the Effect of Severely Diminished Liver Function on the Metabolism, Safety, and Tolerability of a Single Oral Dose of Enzalutamide in Men

Who this might be right for
Severe Hepatic ImpairmentNormal Hepatic Function
Astellas Pharma Europe B.V. 16
Early research (Phase 1)Study completedNCT01120314
What this trial is testing

Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild, Moderate and Severe Renal Impairment

Who this might be right for
Renal Impairment
Sanofi 48
Early research (Phase 1)Study completedNCT03443063
What this trial is testing

Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Normal Renal Function or With Severe Renal Impairment

Who this might be right for
Renal Impairment
Eisai Inc. 16
Not applicableStudy completedNCT05813353
What this trial is testing

Pre- and Post TAVI Cognitive Functioning and Intraoperative Carotid Flow Measurements

Who this might be right for
Cognitive ImpairmentOlder People--Abuse ofAortic Stenosis, Severe
Catharina Ziekenhuis Eindhoven 54
Early research (Phase 1)Study completedNCT00118170
What this trial is testing

Sorafenib in Treating Patients With Metastatic or Unresectable Solid Tumors, Multiple Myeloma, or Non-Hodgkin's Lymphoma With or Without Impaired Liver or Kidney Function

Who this might be right for
Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid TissueNodal Marginal Zone B-cell LymphomaRecurrent Adult Burkitt Lymphoma+42 more
National Cancer Institute (NCI) 150
Early research (Phase 1)Study completedNCT00698464
What this trial is testing

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Who this might be right for
Hepatic CirrhosisAlcoholism
Novartis Pharmaceuticals 34
Early research (Phase 1)Study completedNCT02096718
What this trial is testing

Afatinib in Subjects With Kidney Dysfunction

Who this might be right for
Renal Insufficiency
Boehringer Ingelheim 30
Early research (Phase 1)Looking for participantsNCT07165002
What this trial is testing

The Pharmacokinetics and Safety of LY3537031 in Participants With Normal Liver Function and With Mild, Moderate, or Severe Liver Impairment

Who this might be right for
HealthyHepatic Insufficiency
Eli Lilly and Company 32
Large-scale testing (Phase 3)Study completedNCT02984124
What this trial is testing

Communication During Hospitalization About Resuscitation Trial

Who this might be right for
Severe Life-limiting COPDSevere Life-limiting Heart FailureSevere Life-limiting Cirrhosis+3 more
University of Vermont 182
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