Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe Functional Impairment”

162 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 162 results

Early research (Phase 1)Looking for participantsNCT06952634
What this trial is testing

An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage

Who this might be right for
Hepatic Impairment
Alumis Inc 48
Early research (Phase 1)Looking for participantsNCT06740799
What this trial is testing

Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment

Who this might be right for
Hepatic Impairment
Daiichi Sankyo 12
Not applicableStudy completedNCT03064308
What this trial is testing

The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery

Who this might be right for
Impaired CognitionQuality of LifeSurgery+7 more
University of Nottingham 11
Early research (Phase 1)Not Yet RecruitingNCT07322016
What this trial is testing

HRS-1301 Tablets in Healthy Subjects and Those With Impaired Kidney Function

Who this might be right for
Hyperlipidemias
Shandong Suncadia Medicine Co., Ltd. 36
Early research (Phase 1)Ended earlyNCT01675973
What this trial is testing

Assess the Effect of Severe Renal Impairment on the Pharmacokinetics, as Well as Safety/Tolerability, of Ranolazine

Who this might be right for
Severe Renal Impairment
Gilead Sciences 4
Not applicableStudy completedNCT05813353
What this trial is testing

Pre- and Post TAVI Cognitive Functioning and Intraoperative Carotid Flow Measurements

Who this might be right for
Cognitive ImpairmentOlder People--Abuse ofAortic Stenosis, Severe
Catharina Ziekenhuis Eindhoven 54
Early research (Phase 1)Looking for participantsNCT06908954
What this trial is testing

The Blood Levels of Palovarotene in Participants With Abnormal Liver Function Compared to Healthy Adult Participants After Intake of a Single Dose

Who this might be right for
Hepatic ImpairmentHealthy
Ipsen 32
Early research (Phase 1)Study completedNCT02108639
What this trial is testing

To Assess the Effect of Renal Impairment on the Blood Levels of Daclatasvir (DCV), Asunaprevir (ASV) and BMS-791325 After Multiple Doses of a Fixed Dose Combination Tablet

Who this might be right for
Hepatitis C
Bristol-Myers Squibb 41
Not applicableStudy completedNCT05912933
What this trial is testing

Learn About the Relationship Between Hepatic Impairment and Myelosuppression (Decreased Bone Marrow Function) in Breast Cancer Patients Treated With the Study Medicine Palbociclib (Pal-bow-sai-klib)

Who this might be right for
Breast Cancer
Pfizer 733
Early research (Phase 1)WithdrawnNCT03545087
What this trial is testing

Lanabecestat in Participants With Severe Kidney Impairment Compared to Healthy Participants

Who this might be right for
Renal Insufficiency
Eli Lilly and Company
Early research (Phase 1)Study completedNCT06126575
What this trial is testing

A PK Study Testing Single Oral Dose of Elacestrant in Subjects With Normal or Severely Impaired Hepatic Function

Who this might be right for
Hepatic Impairment
Stemline Therapeutics, Inc. 16
Early research (Phase 1)Study completedNCT03664544
What this trial is testing

PK Study in Subjects With Severe Hepatic Impairment

Who this might be right for
Severe Hepatic ImpairmentHealthy
Tanabe Pharma Corporation 12
Early research (Phase 1)Study completedNCT02016911
What this trial is testing

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

Who this might be right for
DiabetesDiabetes Mellitus, Type 2Healthy
Novo Nordisk A/S 56
Early research (Phase 1)Study completedNCT01766154
What this trial is testing

Pharmacokinetic Evaluation of Tirofiban Using a Single High-Dose Bolus In Subjects With Varying Degrees of Renal Function

Who this might be right for
Renal Insufficiency
Medicure 25
Early research (Phase 1)Study completedNCT03196206
What this trial is testing

Evaluate Pharmacokinetics and Safety of BMS-986177 in Participants With Normal Renal Function and With Moderate or Severe Renal Impairment

Who this might be right for
Thrombosis
Bristol-Myers Squibb 24
Early research (Phase 1)Study completedNCT02170220
What this trial is testing

Pharmacokinetics, Safety and Tolerability of Vortioxetine in Normal Hepatic Function or Severe Hepatic Impairment

Who this might be right for
Severe Hepatic Impairment
Takeda 12
Large-scale testing (Phase 3)UnknownNCT00905944
What this trial is testing

Exercise in Patients With a Biventricular Pacemaker

Who this might be right for
Left Ventricular Failure
Charite University, Berlin, Germany 45
Early research (Phase 1)Study completedNCT02923947
What this trial is testing

Study to Assess Osimertinib in Patients w/ Adv Solid Tumours & Normal Kidney Function or Severe Kidney Impairment

Who this might be right for
Solid Tumours
AstraZeneca 16
Early research (Phase 1)Study completedNCT06318676
What this trial is testing

Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

Who this might be right for
Renal Impairment
Celgene 26
Early research (Phase 1)Study completedNCT04056468
What this trial is testing

Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Who this might be right for
Hepatic ImpairmentHealthy Volunteers
Millennium Pharmaceuticals, Inc. 24
Load More Results