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Results for “Severe Functional Impairment”

163 trials

Showing 20 of 163 results

Early research (Phase 1)Study completedNCT02016911
What this trial is testing

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

Who this might be right for
DiabetesDiabetes Mellitus, Type 2Healthy
Novo Nordisk A/S 56
Early research (Phase 1)Not Yet RecruitingNCT07250633
What this trial is testing

Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control Participants

Who this might be right for
Severe Hepatic ImpairmentNormal Hepatic Function
Institut de Recherches Internationales Servier (I.R.I.S.) 20
Early research (Phase 1)Study completedNCT01046058
What this trial is testing

TMC435-TiDP16-C113: A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of TMC435

Who this might be right for
Hepatitis C Virus
Tibotec Pharmaceuticals, Ireland 23
Early research (Phase 1)Looking for participantsNCT06916078
What this trial is testing

Lepodisiran (LY3819469) in Participants With Normal, Mild, Moderate, or Severe Liver Function

Who this might be right for
Liver DysfunctionHealthy
Eli Lilly and Company 33
Early research (Phase 1)Study completedNCT01830816
What this trial is testing

Pharmacokinetics Study of Oral Ixazomib (MLN9708) in Relapsed/Refractory Multiple Myeloma and Advanced Solid Tumors Participants With Normal Renal Function or Severe Renal Impairment

Who this might be right for
Multiple MyelomaAdvanced Solid Tumors
Millennium Pharmaceuticals, Inc. 41
Early research (Phase 1)Looking for participantsNCT04953897
What this trial is testing

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic Syndromes
Taiho Oncology, Inc. 18
Early research (Phase 1)Study completedNCT05404542
What this trial is testing

To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function

Who this might be right for
Renal Impairment
Cerevel Therapeutics, LLC 14
Early research (Phase 1)Study completedNCT03196206
What this trial is testing

Evaluate Pharmacokinetics and Safety of BMS-986177 in Participants With Normal Renal Function and With Moderate or Severe Renal Impairment

Who this might be right for
Thrombosis
Bristol-Myers Squibb 24
Post-approval studies (Phase 4)Study completedNCT01770652
What this trial is testing

An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild, Moderate, Severe, or No Renal Impairment

Who this might be right for
Renal Impairment
ApoPharma 32
Early research (Phase 1)Study completedNCT02172118
What this trial is testing

BI 1744 CL in Patients With Severe Renal Impairment in Comparison to Subjects With Normal Renal Function

Who this might be right for
Healthy
Boehringer Ingelheim 22
Early research (Phase 1)Study completedNCT04190654
What this trial is testing

Single-dose Study to Investigate the Plasma PK of KW-6356 and Its Major Metabolite

Who this might be right for
Hepatic Impairment
Kyowa Kirin, Inc. 26
Early research (Phase 1)Study completedNCT05940402
What this trial is testing

Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function

Who this might be right for
Renal Impairment
AbbVie 58
Early research (Phase 1)Study completedNCT00863161
What this trial is testing

Renal Impairment Study

Who this might be right for
RefluxRenal Excretion
AstraZeneca 23
Early research (Phase 1)Looking for participantsNCT07231991
What this trial is testing

Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function

Who this might be right for
Healthy Participants
Pfizer 24
Large-scale testing (Phase 3)Study completedNCT04119843
What this trial is testing

Safety and Diagnostic Efficacy of Mangoral in Participants With Focal Liver Lesions and Reduced Kidney Function

Who this might be right for
Known or Suspected Focal Liver LesionsSevere Renal Impairment
Ascelia Pharma AB 87
Early research (Phase 1)Study completedNCT04024332
What this trial is testing

Study of the Way the Body Takes up, Distributes, and Gets Rid of ACT-541468 in Subjects With Abnormal Kidney Function Compared to Healthy Subjects

Who this might be right for
Renal InsufficiencyHealthy
Idorsia Pharmaceuticals Ltd. 16
Early research (Phase 1)Study completedNCT03259087
What this trial is testing

Pharmacokinetics (PK) and Safety of a Single Intravenous (IV) Dose of MK-3866 in Participants With Impaired Renal Function and in Healthy Controls (MK-3866-005)

Who this might be right for
Renal Impairment
Merck Sharp & Dohme LLC 42
Early research (Phase 1)Not Yet RecruitingNCT07322016
What this trial is testing

HRS-1301 Tablets in Healthy Subjects and Those With Impaired Kidney Function

Who this might be right for
Hyperlipidemias
Shandong Suncadia Medicine Co., Ltd. 36
Early research (Phase 1)Ended earlyNCT01675973
What this trial is testing

Assess the Effect of Severe Renal Impairment on the Pharmacokinetics, as Well as Safety/Tolerability, of Ranolazine

Who this might be right for
Severe Renal Impairment
Gilead Sciences 4
Early research (Phase 1)Study completedNCT01374113
What this trial is testing

Safinamide Renal Impairment Trial

Who this might be right for
Renal Impairment
Newron Pharmaceuticals SPA 24
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