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Results for “Severe Functional Impairment”

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Showing 20 of 0 results

Large-scale testing (Phase 3)Study completedNCT03242018
What this trial is testing

Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control

Who this might be right for
Type 2 Diabetes MellitusChronic Kidney Disease Stage 4
Lexicon Pharmaceuticals 277
Early research (Phase 1)Study completedNCT03196206
What this trial is testing

Evaluate Pharmacokinetics and Safety of BMS-986177 in Participants With Normal Renal Function and With Moderate or Severe Renal Impairment

Who this might be right for
Thrombosis
Bristol-Myers Squibb 24
Not applicableStudy completedNCT05912933
What this trial is testing

Learn About the Relationship Between Hepatic Impairment and Myelosuppression (Decreased Bone Marrow Function) in Breast Cancer Patients Treated With the Study Medicine Palbociclib (Pal-bow-sai-klib)

Who this might be right for
Breast Cancer
Pfizer 1,342
Early research (Phase 1)Study completedNCT03687554
What this trial is testing

Effect of Venglustat in Patients With Renal Impairment

Who this might be right for
Healthy VolunteersPolycystic Kidney, Autosomal Dominant
Genzyme, a Sanofi Company 24
Early research (Phase 1)Study completedNCT02296853
What this trial is testing

Study to Evaluate the Pharmacokinetics of Tenofovir Alafenamide (TAF) in Adults With Normal Hepatic Function and Adults With Severe Hepatic Impairment

Who this might be right for
Hepatitis B Virus
Gilead Sciences 20
Early research (Phase 1)Study completedNCT01563562
What this trial is testing

Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Who this might be right for
Hepatic ImpairmentHealthy
Biogen 34
Early research (Phase 1)Study completedNCT02016911
What this trial is testing

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

Who this might be right for
DiabetesDiabetes Mellitus, Type 2Healthy
Novo Nordisk A/S 56
Early research (Phase 1)Active Not RecruitingNCT07426380
What this trial is testing

Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function

Who this might be right for
Kidney DiseaseRenal Insufficiency ChronicKidney Failure, Chronic+3 more
Eli Lilly and Company 28
Early research (Phase 1)Study completedNCT05404542
What this trial is testing

To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function

Who this might be right for
Renal Impairment
Cerevel Therapeutics, LLC 14
Early research (Phase 1)Ended earlyNCT04241835
What this trial is testing

Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Who this might be right for
Hepatic ImpairmentAdvanced Malignant Solid Tumor
Epizyme, Inc. 18
Early research (Phase 1)Study completedNCT05718648
What this trial is testing

Test How BI 1015550 is Taken up in the Blood of People With and Without Kidney Problems

Who this might be right for
Renal InsufficiencyHealthy
Boehringer Ingelheim 26
Not applicableStudy completedNCT01539746
What this trial is testing

Transcatheter Aortic Valve Implantation Without Predilation

Who this might be right for
Aortic StenosisLeft Ventricular Function Systolic DysfunctionHigh-risk Patients+1 more
University Hospital, Bonn 110
Early research (Phase 1)Study completedNCT06397872
What this trial is testing

Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses (6 Days) of 100 mg Resmetirom in Subjects With Severe Renal Impairment and in Matched Healthy Control Subjects With Normal Renal Function

Who this might be right for
Renal Impairment
Madrigal Pharmaceuticals, Inc. 28
Early research (Phase 1)Study completedNCT00791401
What this trial is testing

The Pharmacokinetics of ER OROS Paliperidone in Volunteers With Normal or Impaired Renal Function

Who this might be right for
SchizophreniaRenal Impairment
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 47
Early research (Phase 1)Study completedNCT05865171
What this trial is testing

Evaluate Pharmacokinetics (PK) and Safety of Inaxaplin in Participants With Renal Impairment

Who this might be right for
Renal Impairment
Vertex Pharmaceuticals Incorporated 16
Early research (Phase 1)Study completedNCT06723535
What this trial is testing

Evaluate BMS-986278 in Participants With Normal Renal Function, Severe Renal Impairment, or End-Stage Renal Disease on Intermittent Hemodialysis

Who this might be right for
Kidney Failure, ChronicHealthy VolunteersRenal Impairment
Bristol-Myers Squibb 27
Early research (Phase 1)Study completedNCT06962774
What this trial is testing

An Investigational Study of ESK-001 in Participants With Normal Renal Function and Participants With Mild, Moderate, and Severe Impaired Renal Function

Who this might be right for
Renal Impairment
Alumis Inc 16
Early research (Phase 1)Active Not RecruitingNCT07168356
What this trial is testing

Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease

Who this might be right for
Hepatitis B
GlaxoSmithKline 32
Early research (Phase 1)Study completedNCT02402452
What this trial is testing

Pharmacokinetics of Voxilaprevir in Adults With Normal Renal Function and Severe Renal Impairment

Who this might be right for
HCV Infection
Gilead Sciences 20
Early research (Phase 1)Study completedNCT05718258
What this trial is testing

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Who this might be right for
Hepatic Function Abnormal
Sanofi 26
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