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Results for “Severe Hepatic Impairment”

123 trials

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Showing 20 of 123 results

Early research (Phase 1)Study completedNCT06052566
What this trial is testing

Efinopegdutide in Participants With Hepatic Impairment (MK-6024-014)

Who this might be right for
Non-alcoholic SteatohepatitisHepatic Impairment
Merck Sharp & Dohme LLC 22
Early research (Phase 1)Study completedNCT02016911
What this trial is testing

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

Who this might be right for
DiabetesDiabetes Mellitus, Type 2Healthy
Novo Nordisk A/S 56
Early research (Phase 1)Not Yet RecruitingNCT07250633
What this trial is testing

Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control Participants

Who this might be right for
Severe Hepatic ImpairmentNormal Hepatic Function
Institut de Recherches Internationales Servier (I.R.I.S.) 20
Early research (Phase 1)Study completedNCT01046058
What this trial is testing

TMC435-TiDP16-C113: A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of TMC435

Who this might be right for
Hepatitis C Virus
Tibotec Pharmaceuticals, Ireland 23
Early research (Phase 1)Looking for participantsNCT06916078
What this trial is testing

Lepodisiran (LY3819469) in Participants With Normal, Mild, Moderate, or Severe Liver Function

Who this might be right for
Liver DysfunctionHealthy
Eli Lilly and Company 33
Early research (Phase 1)Study completedNCT03341884
What this trial is testing

Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants

Who this might be right for
Hepatic Insufficiency
Genentech, Inc. 29
Early research (Phase 1)Study completedNCT01767623
What this trial is testing

The Impact of Severe Hepatic Impairment on the Pharmacokinetics and Safety of Vemurafenib in BRAF V600 Mutation-Positive Cancer Participants

Who this might be right for
Neoplasms
Hoffmann-La Roche 8
Early research (Phase 1)Study completedNCT04190654
What this trial is testing

Single-dose Study to Investigate the Plasma PK of KW-6356 and Its Major Metabolite

Who this might be right for
Hepatic Impairment
Kyowa Kirin, Inc. 26
Early research (Phase 1)Looking for participantsNCT07231991
What this trial is testing

Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function

Who this might be right for
Healthy Participants
Pfizer 24
Early research (Phase 1)Study completedNCT01727128
What this trial is testing

Pharmacokinetic Study of BKM120 in Subjects With Hepatic Impairment

Who this might be right for
Hepatic Impairment
Novartis Pharmaceuticals 31
Early research (Phase 1)Study completedNCT03814005
What this trial is testing

Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, ChronicLeukemia, Myeloid, Acute+3 more
Takeda 17
Early research (Phase 1)Study completedNCT00359463
What this trial is testing

Study Of Eltrombopag in Healthy Subjects and Volunteers With Mild, Moderate or Severe Hepatic Impairment

Who this might be right for
Purpura, Thrombocytopaenic, Idiopathic
GlaxoSmithKline 33
Post-approval studies (Phase 4)Ended earlyNCT03633227
What this trial is testing

Study of Obeticholic Acid (OCA) Evaluating Pharmacokinetics and Safety in Participants With Primary Biliary Cholangitis (PBC) and Hepatic Impairment

Who this might be right for
Liver Cirrhosis, Biliary
Intercept Pharmaceuticals 22
Early research (Phase 1)Study completedNCT05882032
What this trial is testing

LY3502970 in Participants With Impaired and Normal Liver Function

Who this might be right for
HealthyHepatic Insufficiency
Eli Lilly and Company 29
Testing effectiveness (Phase 2)Looking for participantsNCT06682988
What this trial is testing

Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

Who this might be right for
Advanced High-Grade Epithelial OvarianPrimary PeritonealFallopian Tube Cancers+2 more
AbbVie 110
Early research (Phase 1)Study completedNCT04056468
What this trial is testing

Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Who this might be right for
Hepatic ImpairmentHealthy Volunteers
Millennium Pharmaceuticals, Inc. 24
Early research (Phase 1)Study completedNCT03664544
What this trial is testing

PK Study in Subjects With Severe Hepatic Impairment

Who this might be right for
Severe Hepatic ImpairmentHealthy
Tanabe Pharma Corporation 12
Early research (Phase 1)Study completedNCT03742882
What this trial is testing

Assess the Pharmacokinetics of CC-90001 in Subjects With Mild, Moderate, and Severe Hepatic Impairment Compared With Healthy Subjects

Who this might be right for
Hepatic Impairment
Celgene 40
Early research (Phase 1)Looking for participantsNCT07036133
What this trial is testing

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

Who this might be right for
Advanced Solid TumorsHematologic Malignancies
Acrotech Biopharma Inc. 24
Early research (Phase 1)Ended earlyNCT02422524
What this trial is testing

Pretomanid in Adults With Hepatic Impairment

Who this might be right for
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID) 14
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