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Results for “Severe Hepatic Impairment”

125 trials

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Showing 20 of 125 results

Early research (Phase 1)Study completedNCT01185873
What this trial is testing

Danoprevir in Healthy Volunteers And Patients With Hepatic Impairment

Who this might be right for
Healthy Volunteer
Hoffmann-La Roche 81
Early research (Phase 1)Study completedNCT01565902
What this trial is testing

Pharmacokinetics of BAF312 in Patients With Hepatic Impairment

Who this might be right for
Hepatic Impairment
Novartis Pharmaceuticals 40
Early research (Phase 1)Study completedNCT05537142
What this trial is testing

Assess the Phamacokinetics of BV100 in Participants with Varying Degrees of Hepatic Impairment

Who this might be right for
Healthy Participants
BioVersys AG 33
Early research (Phase 1)Study completedNCT01600976
What this trial is testing

Assess Safety and Pharmacokinetics of Telaprevir in Patients With Hepatic Impairment

Who this might be right for
Hepatic Impairment
Janssen Infectious Diseases BVBA 24
Early research (Phase 1)Study completedNCT04154774
What this trial is testing

Apalutamide in Participants With Severe Hepatic Impairment Compared With Participants With Normal Hepatic Function

Who this might be right for
Hepatic Impairment
Janssen Research & Development, LLC 18
Early research (Phase 1)Looking for participantsNCT06911320
What this trial is testing

Study of Bemnifosbuvir/Ruzasvir as a Fixed-dose Combination in Subjects With Normal or Severely Impaired Renal or Hepatic Function

Who this might be right for
Healthy Volunteer StudyHepatic ImpairmentRenal Impairment
Atea Pharmaceuticals, Inc. 28
Early research (Phase 1)Ended earlyNCT05209295
What this trial is testing

Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies

Who this might be right for
Hepatic InsufficiencyNeoplasms
Bristol-Myers Squibb 2
Early research (Phase 1)Study completedNCT06952634
What this trial is testing

An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage

Who this might be right for
Hepatic Impairment
Alumis Inc 32
Early research (Phase 1)Study completedNCT00698464
What this trial is testing

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Who this might be right for
Hepatic CirrhosisAlcoholism
Novartis Pharmaceuticals 34
Early research (Phase 1)Ended earlyNCT04241835
What this trial is testing

Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Who this might be right for
Hepatic ImpairmentAdvanced Malignant Solid Tumor
Epizyme, Inc. 18
Early research (Phase 1)Study completedNCT01817985
What this trial is testing

Evaluate the Pharmacokinetics of GS-5816 in Subjects With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Who this might be right for
Chronic Hepatitis C
Gilead Sciences 33
Early research (Phase 1)Study completedNCT03341884
What this trial is testing

Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants

Who this might be right for
Hepatic Insufficiency
Genentech, Inc. 29
Early research (Phase 1)WithdrawnNCT04759846
What this trial is testing

Hepatic Impairment Study of Encorafenib in Combination With Binimetinib in BRAF Melanoma

Who this might be right for
BRAF V600 MutationUnresectable MelanomaMetastatic Melanoma+1 more
Pierre Fabre Medicament
Early research (Phase 1)Study completedNCT02683577
What this trial is testing

Study to Evaluate a Dose of Telotristat Etiprate in Male and Female With Mild, Moderate and Severe Hepatic Insufficiency and Matched Healthy Subjects

Who this might be right for
Hepatic Impairment
Ipsen 24
Early research (Phase 1)Study completedNCT03814005
What this trial is testing

Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, ChronicLeukemia, Myeloid, Acute+3 more
Takeda 17
Early research (Phase 1)Looking for participantsNCT07165002
What this trial is testing

The Pharmacokinetics and Safety of LY3537031 in Participants With Normal Liver Function and With Mild, Moderate, or Severe Liver Impairment

Who this might be right for
HealthyHepatic Insufficiency
Eli Lilly and Company 32
Early research (Phase 1)Study completedNCT05882032
What this trial is testing

LY3502970 in Participants With Impaired and Normal Liver Function

Who this might be right for
HealthyHepatic Insufficiency
Eli Lilly and Company 29
Early research (Phase 1)Study completedNCT06812780
What this trial is testing

Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD2389

Who this might be right for
Hepatic Impairment
AstraZeneca 35
Early research (Phase 1)Study completedNCT03713242
What this trial is testing

Evaluate the Pharmacokinetics of ACT-541468 in Subjects With Mild, Moderate, and Severe Hepatic Impairment

Who this might be right for
Hepatic Impairment
Idorsia Pharmaceuticals Ltd. 32
Early research (Phase 1)Looking for participantsNCT07231991
What this trial is testing

Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function

Who this might be right for
Healthy Participants
Pfizer 24
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