Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe Knee Pain”

96 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 96 results

Post-approval studies (Phase 4)Study completedNCT00426647
What this trial is testing

Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip Knee and/or Lumbar Spine

Who this might be right for
OsteoarthritisPain
Norpharma A/S 120
Large-scale testing (Phase 3)Study completedNCT03661996
What this trial is testing

An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA

Who this might be right for
Knee Osteoarthritis
Centrexion Therapeutics 854
Testing effectiveness (Phase 2)UnknownNCT04885972
What this trial is testing

Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis

Who this might be right for
Osteoarthritis, KneeKnee OsteoarthritisKnee Pain Chronic
Sorrento Therapeutics, Inc. 124
Large-scale testing (Phase 3)Study completedNCT00531427
What this trial is testing

Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee

Who this might be right for
Chronic PainOsteoarthritis of the Knee
Purdue Pharma LP 567
Large-scale testing (Phase 3)Ended earlyNCT01400607
What this trial is testing

Neocartilage Implant to Treat Cartilage Lesions of the Knee

Who this might be right for
Articular Cartilage DisorderDegeneration; Articular CartilageChronic Cartilage Injury+2 more
ISTO Technologies, Inc. 14
Large-scale testing (Phase 3)Study completedNCT00348452
What this trial is testing

A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)

Who this might be right for
Chronic Pain
Bausch Health Americas, Inc. 1,000
Not applicableActive Not RecruitingNCT02337244
What this trial is testing

Zimmer POLAR Persona - TKA (EMEA Study)

Who this might be right for
Severe Knee PainSevere Knee DisabilityOsteoarthritis+3 more
Zimmer, GmbH 777
Large-scale testing (Phase 3)Study completedNCT00420992
What this trial is testing

Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee

Who this might be right for
OsteoarthritisChronic Pain
Pfizer 547
Large-scale testing (Phase 3)Study completedNCT01559701
What this trial is testing

Long-term Safety of PF-00345439 (Oxycodone)

Who this might be right for
Pain
Pain Therapeutics 823
Not applicableStudy completedNCT06664905
What this trial is testing

Resistance Exercise in Severe Knee Osteoarthritis

Who this might be right for
Knee Osteoarthritis
University of Valencia 28
Testing effectiveness (Phase 2)Study completedNCT05025787
What this trial is testing

Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.

Who this might be right for
Knee Osteoarthritis
Maurizio Fava, MD 55
Testing effectiveness (Phase 2)Ended earlyNCT00973141
What this trial is testing

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain

Who this might be right for
OsteoarthritisOsteoarthritis, HipOsteoarthritis, Knee+3 more
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 467
Large-scale testing (Phase 3)Study completedNCT00983073
What this trial is testing

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic

Who this might be right for
Chronic PainOsteoarthritis
Grünenthal GmbH 224
Testing effectiveness (Phase 2)Ended earlyNCT01094262
What this trial is testing

A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis

Who this might be right for
OsteoarthritisOsteoarthritis, KneePain+2 more
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 196
Large-scale testing (Phase 3)Ended earlyNCT00982280
What this trial is testing

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.

Who this might be right for
Chronic PainOsteoarthritis
Grünenthal GmbH 82
Large-scale testing (Phase 3)Study completedNCT00902837
What this trial is testing

OXN PR Compared to OxyPR to Demonstrate Non-inferiority in Pain & Locomotor Function & Improvement in Symptoms of Constipation in OA Subjects

Who this might be right for
Chronic Osteoarthritis
Mundipharma Research GmbH & Co KG 181
Testing effectiveness (Phase 2)Study completedNCT05216341
What this trial is testing

Study of OLP-1002 Injections for Reducing Moderate to Severe Pain Due to Osteoarthritis in Hip and/or Knee Joint

Who this might be right for
Osteoarthritis
OliPass Corporation 134
Testing effectiveness (Phase 2)Ended earlyNCT02847702
What this trial is testing

Evaluate the Analgesic Efficacy and Safety of VM902A in Subjects With Osteoarthritis (OA) of the Knee

Who this might be right for
Osteoarthritis Pain of the Knee
Purdue Pharma LP 75
Not applicableStudy completedNCT07252817
What this trial is testing

Intensive Monitoring of Post-surgery Pain in Major Ambulatory Surgery

Who this might be right for
HernioplastyCholecystectomy, LaparoscopicHaemorrhoidal Surgery+2 more
Consorci Sanitari del Maresme 280
Testing effectiveness (Phase 2)Study completedNCT00394563
What this trial is testing

A Phase II Study Looking at Moderate to Severe Osteoarthritis Knee Pain

Who this might be right for
Osteoarthritis
Pfizer 450
Next Page