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Results for “Severe Knee Pain”

93 trials

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Showing 20 of 93 results

Early research (Phase 1)Study completedNCT03542838
What this trial is testing

Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis

Who this might be right for
Osteoarthritis, KneePain, Knee
Sorrento Therapeutics, Inc. 94
Testing effectiveness (Phase 2)Ended earlyNCT00973141
What this trial is testing

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain

Who this might be right for
OsteoarthritisOsteoarthritis, HipOsteoarthritis, Knee+3 more
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 467
Large-scale testing (Phase 3)Study completedNCT03429049
What this trial is testing

Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain

Who this might be right for
Osteoarthritis, Knee
Centrexion Therapeutics 332
Post-approval studies (Phase 4)WithdrawnNCT01631513
What this trial is testing

An Open-label Evaluation of Tapentadol Extended Release (ER) in Participants With Moderate to Severe Chronic Pain After Conversion From Hydrocodone, Oxycodone Controlled Release (CR), and/or Morphine Sustained Release (SR)

Who this might be right for
PainChronic Back PainChronic Low Back Pain+1 more
Janssen Scientific Affairs, LLC
Not applicableWithdrawnNCT04472091
What this trial is testing

Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain

Who this might be right for
Knee OsteoarthritisKnee Pain ChronicKnee Pain Swelling+2 more
Andrew Picel
Testing effectiveness (Phase 2)Study completedNCT00669409
What this trial is testing

A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee

Who this might be right for
Osteoarthritis, Knee
Pfizer 83
Large-scale testing (Phase 3)Study completedNCT00420992
What this trial is testing

Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee

Who this might be right for
OsteoarthritisChronic Pain
Pfizer 547
Large-scale testing (Phase 3)Ended earlyNCT01400607
What this trial is testing

Neocartilage Implant to Treat Cartilage Lesions of the Knee

Who this might be right for
Articular Cartilage DisorderDegeneration; Articular CartilageChronic Cartilage Injury+2 more
ISTO Technologies, Inc. 14
Testing effectiveness (Phase 2)Study completedNCT04129944
What this trial is testing

Assess the Safety and Efficacy of a Single Dose of UBX0101 in Patients With Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis, Knee
Unity Biotechnology, Inc. 183
Not applicableStudy completedNCT05112926
What this trial is testing

Effectiveness and Safety of Embosphere Microspheres for Embolization of the Geniculate Artery for the Treatment of Pain With Known Moderate to Severe Knee Osteoarthritis

Who this might be right for
Knee Osteoarthritis
University of Miami 9
Not applicableLooking for participantsNCT05981105
What this trial is testing

Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty

Who this might be right for
Chronic PainOpioid UseAdductor Canal Block+1 more
Hospital for Special Surgery, New York 64
Testing effectiveness (Phase 2)Study completedNCT00667654
What this trial is testing

Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)

Who this might be right for
Osteoarthritis of the Knee
Centrexion Therapeutics 54
Testing effectiveness (Phase 2)Study completedNCT00979953
What this trial is testing

Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis of the Knee
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 408
Large-scale testing (Phase 3)Study completedNCT00421928
What this trial is testing

Tapentadol (CG5503)

Who this might be right for
Osteoarthritis, KneePain
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 1,030
Testing effectiveness (Phase 2)Study completedNCT00819572
What this trial is testing

Study of Intra-articular DLX105 Applied to Patients With Severely Painful Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis
ESBATech AG 27
Testing effectiveness (Phase 2)Study completedNCT01619839
What this trial is testing

Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain

Who this might be right for
Osteoarthritis of the Knee
Nektar Therapeutics 296
Large-scale testing (Phase 3)Study completedNCT01559701
What this trial is testing

Long-term Safety of PF-00345439 (Oxycodone)

Who this might be right for
Pain
Pain Therapeutics 823
Large-scale testing (Phase 3)Study completedNCT05377489
What this trial is testing

Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis
Grünenthal GmbH 714
Not applicableActive Not RecruitingNCT02337244
What this trial is testing

Zimmer POLAR Persona - TKA (EMEA Study)

Who this might be right for
Severe Knee PainSevere Knee DisabilityOsteoarthritis+3 more
Zimmer, GmbH 777
Early research (Phase 1)Not Yet RecruitingNCT07351968
What this trial is testing

A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis

Who this might be right for
Moderate Pain in Knee OsteoarthritisSevere Pain in Knee Osteoarthritis
Shandong Suncadia Medicine Co., Ltd. 200
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