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Results for “Severe Osteoarthritis of the Knee”

127 trials

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Showing 20 of 127 results

Early research (Phase 1)Study completedNCT03542838
What this trial is testing

Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis

Who this might be right for
Osteoarthritis, KneePain, Knee
Sorrento Therapeutics, Inc. 94
Testing effectiveness (Phase 2)Ended earlyNCT00973141
What this trial is testing

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain

Who this might be right for
OsteoarthritisOsteoarthritis, HipOsteoarthritis, Knee+3 more
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 467
Post-approval studies (Phase 4)UnknownNCT03090698
What this trial is testing

Outcomes of Injections in Patients Waiting for Total Knee Replacement

Who this might be right for
Osteoarthritis of the Knee
Universidade Federal Fluminense 120
Large-scale testing (Phase 3)Study completedNCT03429049
What this trial is testing

Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain

Who this might be right for
Osteoarthritis, Knee
Centrexion Therapeutics 332
Post-approval studies (Phase 4)WithdrawnNCT01631513
What this trial is testing

An Open-label Evaluation of Tapentadol Extended Release (ER) in Participants With Moderate to Severe Chronic Pain After Conversion From Hydrocodone, Oxycodone Controlled Release (CR), and/or Morphine Sustained Release (SR)

Who this might be right for
PainChronic Back PainChronic Low Back Pain+1 more
Janssen Scientific Affairs, LLC
Not applicableWithdrawnNCT04472091
What this trial is testing

Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain

Who this might be right for
Knee OsteoarthritisKnee Pain ChronicKnee Pain Swelling+2 more
Andrew Picel
Testing effectiveness (Phase 2)Study completedNCT00669409
What this trial is testing

A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee

Who this might be right for
Osteoarthritis, Knee
Pfizer 83
Large-scale testing (Phase 3)Study completedNCT00420992
What this trial is testing

Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee

Who this might be right for
OsteoarthritisChronic Pain
Pfizer 547
Testing effectiveness (Phase 2)Looking for participantsNCT06485843
What this trial is testing

Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint

Who this might be right for
OsteoarthritisOsteo Arthritis Knee
Ageless Biotech, Inc. 400
Testing effectiveness (Phase 2)Study completedNCT04129944
What this trial is testing

Assess the Safety and Efficacy of a Single Dose of UBX0101 in Patients With Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis, Knee
Unity Biotechnology, Inc. 183
Not applicableNot Yet RecruitingNCT06767787
What this trial is testing

Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?

Who this might be right for
Osteoarthritis of KneeArthroplasties, Knee ReplacementSleeve Gastrectomy
Memorial University of Newfoundland 142
Not applicableStudy completedNCT05112926
What this trial is testing

Effectiveness and Safety of Embosphere Microspheres for Embolization of the Geniculate Artery for the Treatment of Pain With Known Moderate to Severe Knee Osteoarthritis

Who this might be right for
Knee Osteoarthritis
University of Miami 9
Not applicableUnknownNCT04088045
What this trial is testing

High Frequency Intensive Autologous PRP Injection and Genicular Nerve Blocks in Treating Knee Osteoarthritis

Who this might be right for
Knee Osteoarthritis
Chang Gung Memorial Hospital 36
Testing effectiveness (Phase 2)Study completedNCT00667654
What this trial is testing

Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)

Who this might be right for
Osteoarthritis of the Knee
Centrexion Therapeutics 54
Testing effectiveness (Phase 2)Study completedNCT00979953
What this trial is testing

Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis of the Knee
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 408
Large-scale testing (Phase 3)Study completedNCT00421928
What this trial is testing

Tapentadol (CG5503)

Who this might be right for
Osteoarthritis, KneePain
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 1,030
Testing effectiveness (Phase 2)Study completedNCT00819572
What this trial is testing

Study of Intra-articular DLX105 Applied to Patients With Severely Painful Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis
ESBATech AG 27
Testing effectiveness (Phase 2)Study completedNCT01619839
What this trial is testing

Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain

Who this might be right for
Osteoarthritis of the Knee
Nektar Therapeutics 296
Not applicableStudy completedNCT02951026
What this trial is testing

An Observational Study Evaluating the Safety, Tolerability, and Efficacy of Treatment of SM04690 or Placebo Previously Injected in the Target Knee Joint of Subjects With Moderately to Severely Symptomatic Osteoarthritis

Who this might be right for
Osteoarthritis
Biosplice Therapeutics, Inc. 703
Large-scale testing (Phase 3)Study completedNCT01559701
What this trial is testing

Long-term Safety of PF-00345439 (Oxycodone)

Who this might be right for
Pain
Pain Therapeutics 823
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