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Results for “Severe Primary Immunodeficiency Disorder”

104 trials

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Showing 20 of 104 results

Not applicableActive Not RecruitingNCT05236764
What this trial is testing

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Who this might be right for
Acute Lymphoblastic Leukemia in RemissionAcute Myeloid Leukemia in RemissionMyelodysplastic Syndromes+8 more
Baylor College of Medicine 3
Testing effectiveness (Phase 2)WithdrawnNCT04370795
What this trial is testing

Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus

Who this might be right for
Severe Combined Immune Deficiency (SCID)
National Institute of Allergy and Infectious Diseases (NIAID)
Testing effectiveness (Phase 2)Looking for participantsNCT03311503
What this trial is testing

Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning

Who this might be right for
Severe Combined Immunodeficiency, X LinkedGene Therapy
David Williams 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT02061800
What this trial is testing

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

Who this might be right for
Chronic Myeloid Leukemia (CML)Acute Myelogenous Leukemia (AML)Myelodysplastic Syndrome (MDS)+3 more
Diane George 14
Not applicableEnrolling By InvitationNCT00895271
What this trial is testing

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Who this might be right for
Primary ImmunodeficiencyDOCK8Virus Susceptibility
National Institute of Allergy and Infectious Diseases (NIAID) 200
Not applicableUnknownNCT00006319
What this trial is testing

Molecular and Clinical Studies of Primary Immunodeficiency Diseases

Who this might be right for
Wiskott- Aldrich SyndromeADA Deficient SCID
National Human Genome Research Institute (NHGRI) 266
Testing effectiveness (Phase 2)Study completedNCT01380990
What this trial is testing

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Who this might be right for
Adenosine Deaminase DeficiencySevere Combined Immunodeficiencies (SCID)
Great Ormond Street Hospital for Children NHS Foundation Trust 36
Not applicableStudy completedNCT00695279
What this trial is testing

Long Term Follow Up Of Patients Who Have Received Gene Therapy Or Gene Marked Products

Who this might be right for
Severe Combined ImmunodeficiencyMalignancy, HematologicNeuroblastoma+2 more
St. Jude Children's Research Hospital 41
Not applicableLooking for participantsNCT00128973
What this trial is testing

Evaluation of Patients With Immune Function Abnormalities

Who this might be right for
Chronic Granulomatous Disease (CGD)X-Linked Severe Combined Immune Deficiency (XSCID)Leukocyte Adhesion Deficiency 1 (LAD)+1 more
National Institute of Allergy and Infectious Diseases (NIAID) 3,500
Testing effectiveness (Phase 2)UnknownNCT04489160
What this trial is testing

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Traumatic Brain Injury

Who this might be right for
Traumatic Brain InjuryTrauma, Head
Leiden University Medical Center 106
Not applicableLooking for participantsNCT06659588
What this trial is testing

Study of Populations at Risk of Developing Chronic Hepatitis Linked to Chronic Enteric Virus Infection in Patients With Primary Immunodeficiency and Secondary Humoral Deficiency

Who this might be right for
Humoral Primary Immunodeficiencies (PIDs)Secondary Form of Humoral ImmunodeficienciesCombined Immunodeficiency (CID)+1 more
Assistance Publique - Hôpitaux de Paris 120
Post-approval studies (Phase 4)WithdrawnNCT03311074
What this trial is testing

Retroviral Insertion Site Methodology Study

Who this might be right for
Immune System Diseases
Fondazione Telethon
Early research (Phase 1)Looking for participantsNCT05077527
What this trial is testing

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

Who this might be right for
AIDS-Related Diffuse Large B-cell LymphomaAIDS-Related Non-Hodgkin LymphomaHIV Infection+12 more
AIDS Malignancy Consortium 20
Testing effectiveness (Phase 2)UnknownNCT03315078
What this trial is testing

Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency

Who this might be right for
X-Linked Combined Immunodeficiency Diseases
National Institute of Allergy and Infectious Diseases (NIAID) 13
Not applicableUnknownNCT01359384
What this trial is testing

Bronchial Inflammation in Patients With Severe Immune Deficiency Under Immunoglobulin Treatment

Who this might be right for
Immune Deficiency
Johann Wolfgang Goethe University Hospital 50
Testing effectiveness (Phase 2)Study completedNCT00794508
What this trial is testing

MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID

Who this might be right for
Severe Combined Immunodeficiency
Donald B. Kohn, M.D. 10
Not applicableStudy completedNCT00043225
What this trial is testing

The Role of Bacteria and Genetic Variations in Cystic Fibrosis

Who this might be right for
Psuedomas InfectionCystic Fibrosis
National Heart, Lung, and Blood Institute (NHLBI) 76
Testing effectiveness (Phase 2)Looking for participantsNCT03217617
What this trial is testing

SCID-X1 Gene Therapy Via Intravenous Lentiviral (Ivlv-X1) Injection

Who this might be right for
SCID, X-Linked
Shenzhen Geno-Immune Medical Institute 10
Testing effectiveness (Phase 2)Study completedNCT00730314
What this trial is testing

Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells

Who this might be right for
Sickle Cell DiseaseThalassemiaAnemia+9 more
Children's Hospital Los Angeles 25
Early research (Phase 1)Looking for participantsNCT03601286
What this trial is testing

Lentiviral Gene Therapy for X-linked Severe Combined Immunodeficiency

Who this might be right for
Severe Combined Immunodeficiency, X-Linked
Great Ormond Street Hospital for Children NHS Foundation Trust 5
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