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Results for “Smoothened”

23 trials

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Enrolling by Invitation

Showing 20 of 23 results

Early research (Phase 1)Ended earlyNCT01071564
What this trial is testing

RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By Surgery

Who this might be right for
Estrogen Receptor NegativeHER2/Neu NegativeProgesterone Receptor Negative+5 more
National Cancer Institute (NCI) 13
Testing effectiveness (Phase 2)UnknownNCT05199584
What this trial is testing

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Who this might be right for
Solid Tumors With PTCH1 Loss-of-function Mutations
Endeavor Biomedicines, Inc. 44
Early research (Phase 1)Study completedNCT05817240
What this trial is testing

A Drug-Drug Interaction Study of ENV-101 (Taladegib) on Nintedanib Pharmacokinetics in Healthy Subjects

Who this might be right for
Idiopathic Pulmonary Fibrosis
Endeavor Biomedicines, Inc. 21
Early research (Phase 1)Study completedNCT01106508
What this trial is testing

A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsRecurrent or Refractory MedulloblastomaLocally Advanced or Metastatic Basal Cell Carcinoma
Novartis Pharmaceuticals 57
Early research (Phase 1)Study completedNCT01456676
What this trial is testing

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

Who this might be right for
Philadelphia Chromosome Positive Chronic Myelogenous Leukemia
Novartis Pharmaceuticals 11
Early research (Phase 1)Study completedNCT01208831
What this trial is testing

An East Asian Study of LDE225

Who this might be right for
Advanced Solid Tumor CancersMedulloblastomaBasal Cell Carcinoma
Novartis Pharmaceuticals 45
Not applicableStudy completedNCT01529450
What this trial is testing

Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors

Who this might be right for
Basal Cell Carcinoma
Anne Chang 11
Testing effectiveness (Phase 2)Ended earlyNCT02254551
What this trial is testing

Safety/Efficacy Study of LDE225 (Sonidegib) Plus Bortezomib in Patients With Relapsed or Relapsed/Refractory Multiple Myeloma

Who this might be right for
Multiple Myeloma
SCRI Development Innovations, LLC 7
Testing effectiveness (Phase 2)Study completedNCT01218477
What this trial is testing

Dasatinib Combination Therapy With the Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML)

Who this might be right for
Leukemia
Bristol-Myers Squibb 33
Testing effectiveness (Phase 2)Study completedNCT04968574
What this trial is testing

A Study Evaluating the Safety and Efficacy of ENV-101 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Who this might be right for
Idiopathic Pulmonary Fibrosis
Endeavor Biomedicines, Inc. 41
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Testing effectiveness (Phase 2)Study completedNCT01842646
What this trial is testing

Phase II Hedgehog Inhibitor for Myelodysplastic Syndrome (MDS)

Who this might be right for
Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)
H. Lee Moffitt Cancer Center and Research Institute 35
Early research (Phase 1)Study completedNCT01576666
What this trial is testing

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Who this might be right for
Dose EscalationSafetyPreliminary Efficacy+9 more
Novartis Pharmaceuticals 120
Testing effectiveness (Phase 2)Study completedNCT00961896
What this trial is testing

A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients

Who this might be right for
Treatment for Basal Cell Carcinomas (BCCs) in Gorlin Syndrome Patients
Novartis Pharmaceuticals 18
Early research (Phase 1)Study completedNCT00670189
What this trial is testing

BMS-833923 (XL139) in Subjects With Advanced or Metastatic Cancer

Who this might be right for
Hedgehog PathwaySmoothenedBasal Cell Carcinoma (BCC)+1 more
Bristol-Myers Squibb 53
Early research (Phase 1)Study completedNCT02323139
What this trial is testing

LDE255 in Combination With Azacitidine for High Risk Myelodysplastic Syndrome Patients

Who this might be right for
MDS
Groupe Francophone des Myelodysplasies 23
Testing effectiveness (Phase 2)Study completedNCT03390296
What this trial is testing

OX40, Venetoclax, Avelumab, Glasdegib, Gemtuzumab Ozogamicin, and Azacitidine in Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Recurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center 50
Testing effectiveness (Phase 2)Study completedNCT01787552
What this trial is testing

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Who this might be right for
Primary MyelofibrosisThrombocytosisEssential Thrombocythemia+7 more
Novartis Pharmaceuticals 50
Testing effectiveness (Phase 2)Ended earlyNCT02226172
What this trial is testing

Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib

Who this might be right for
Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
Pfizer 21
Early research (Phase 1)Study completedNCT00880308
What this trial is testing

Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumor CancersMedulloblastomaBasal Cell Carcinoma
Novartis Pharmaceuticals 103
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