Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “TP53 Gene Mutation”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Not applicableNot Yet RecruitingNCT07591532
What this trial is testing

Pregnancy Outcomes After Breast Cancer in Young Women With Germline Pathogenic Variants in Genes Other Than BRCA

Who this might be right for
Breast CancerBreast Cancer and Pregnancy
Jules Bordet Institute 2,200
Large-scale testing (Phase 3)Active Not RecruitingNCT03836261
What this trial is testing

Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

Who this might be right for
Chronic Lymphocytic Leukemia
Acerta Pharma BV 984
Early research (Phase 1)Looking for participantsNCT06908434
What this trial is testing

A Phase I First-in-Human Study of GenSci128 in Patients With Solid Tumors Harboring a TP53 Y220C Mutation

Who this might be right for
Solid Tumors Harboring a TP53 Y220C Mutation
Changchun GeneScience Pharmaceutical Co., Ltd. 82
Testing effectiveness (Phase 2)Looking for participantsNCT07499271
What this trial is testing

Genetic Subtype-matched Targeted Therapy for the Treatment of Newly Diagnosed DLBCL With TP53 Mutation

Who this might be right for
Diffuse Large B-Cell Lymphoma (DLBCL)
The First Affiliated Hospital of Soochow University 35
Not applicableStudy completedNCT04872036
What this trial is testing

Prognostic Biomarkers in Patients With Urothelial Carcinoma

Who this might be right for
Bladder Cancer
Hellenic Cooperative Oncology Group 66
Testing effectiveness (Phase 2)Study completedNCT02758665
What this trial is testing

Trial of Ibrutinib Plus Venetoclax Plus Obinutuzumab in Patients With CLL

Who this might be right for
Leukemia, Lymphocytic, Chronic
University of Ulm 41
Testing effectiveness (Phase 2)Looking for participantsNCT07240194
What this trial is testing

The Efficacy and Safety of Glofitamab in Combination With PD-1 Antibody and Lenalidomide in Patients With Relapsed/Refractory Large B-cell Lymphoma (LBCL) With TP53 Aberrations: A Prospective, Multicenter, Phase II Clinical Study

Who this might be right for
Large B-cell LymphomaTP53
The First Affiliated Hospital with Nanjing Medical University 24
Testing effectiveness (Phase 2)Study completedNCT05512377
What this trial is testing

Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder

Who this might be right for
Pancreatic NeoplasmsSolid TumorsBiliary Tract Cancer+2 more
Boehringer Ingelheim 99
Not applicableStudy completedNCT04976439
What this trial is testing

Patogenic Mutation in 5 Genes

Who this might be right for
Colorectal CancerAPC Gene MutationTP53 Gene Mutation+3 more
Dr Cipto Mangunkusumo General Hospital 22
Early research (Phase 1)Study completedNCT05155709
What this trial is testing

Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy.

Who this might be right for
Acute Myeloid Leukemia
Novartis Pharmaceuticals 14
Not applicableUnknownNCT04812938
What this trial is testing

Exploiting Pathogenic Tp53 Mutation for Early Diagnosis of Ovarian Cancer by Mean of Papanicolau Test

Who this might be right for
Ovarian Cancer
Azienda Ospedaliera San Giovanni Battista 190
Testing effectiveness (Phase 2)Ended earlyNCT02612285
What this trial is testing

Study of SNX-5422 in TP53 Null Cancers

Who this might be right for
Cancer
Esanex Inc. 1
Early research (Phase 1)Looking for participantsNCT07372625
What this trial is testing

Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

Who this might be right for
TP53 Y220C MutationAdvanced Solid Tumors
PMV Pharmaceuticals, Inc 14
Testing effectiveness (Phase 2)Looking for participantsNCT07060989
What this trial is testing

Safety, Tolerability and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

Who this might be right for
Advanced Solid Tumors
Nutshell Therapeutics (Shanghai) Co., LTD. 220
Not applicableStudy completedNCT00001148
What this trial is testing

Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor

Who this might be right for
AstrocytomaGlioblastomaGlioma
National Institute of Neurological Disorders and Stroke (NINDS) 25
Not applicableLooking for participantsNCT07419893
What this trial is testing

Germline Genetic Testing of the TP53 Gene

Who this might be right for
TP53 Gene MutationMulti-Gene Transcriptional ProfilingTP53 Gene Germline Mutation Carrier
European Institute of Oncology 1,940
Large-scale testing (Phase 3)Study completedNCT02950051
What this trial is testing

Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation

Who this might be right for
Chronic Lymphocytic Leukemia
German CLL Study Group 926
Testing effectiveness (Phase 2)Study completedNCT03732352
What this trial is testing

18F-FDG PET and Osimertinib in Evaluating Glucose Utilization in Patients with EGFR Activated Recurrent Glioblastoma

Who this might be right for
EGFR Gene AmplificationEGFR Gene MutationGlioblastoma+3 more
Jonsson Comprehensive Cancer Center 12
Early research (Phase 1)Study completedNCT03714958
What this trial is testing

Trametinib + HDM201 in CRC Patients With RAS/RAF Mutant and TP53 Wild-type Advanced/Metastatic Colorectal Cancer Mutant and TP53 Wild-type

Who this might be right for
Colorectal CancerAdvanced CancerMetastatic Cancer
Centre Leon Berard 12
Testing effectiveness (Phase 2)UnknownNCT00082979
What this trial is testing

Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer

Who this might be right for
Breast Cancer
Royal Marsden NHS Foundation Trust 60
Next Page