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Results for “Transthyretin Amyloidosis With Polyneuropathy”

39 trials

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Showing 20 of 39 results

Not applicableStudy completedNCT05560555
What this trial is testing

Retrospective Study Collecting Neurological Follow-up of Hereditary Transthyretin Amyloidosis (ATTRv) Patients Included in B3461028 and B3461045.

Who this might be right for
Hereditary Transthyretin Amyloidosis (ATTRv)Polyneuropathy
Pfizer 5
Large-scale testing (Phase 3)WithdrawnNCT04418024
What this trial is testing

Efficacy and Safety of AG10 in Subjects with Transthyretin Amyloid Polyneurophathy

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy
Eidos Therapeutics, a BridgeBio company
Not applicableLooking for participantsNCT06845644
What this trial is testing

Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients

Who this might be right for
Charcot-Marie-Tooth Neuropathy Type 1AHereditary Transthyretin Amyloid NeuropathyAcquired Demyelinating Neuropathy
Assistance Publique Hopitaux De Marseille 120
Large-scale testing (Phase 3)WithdrawnNCT04882735
What this trial is testing

Efficacy and Safety of Acoramidis (AG10) in Subjects with Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy
Eidos Therapeutics, a BridgeBio company
Testing effectiveness (Phase 2)Looking for participantsNCT06539208
What this trial is testing

A Phase I/IIa，Open-label, Single Ascending Dose and Dose-expansion Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of YOLT-201 in Patients With Transthyretin Amyloidosis Polyneuropathy (ATTR-PN) or Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin Amyloidosis PolyneuropathyTransthyrexin Amyloidosis Cardiomyopathy
YolTech Therapeutics Co., Ltd 31
Not applicableActive Not RecruitingNCT06360289
What this trial is testing

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Who this might be right for
Hereditary Amyloidosis, Transthyretin-RelatedAsymptomatic Carrier State
Alnylam Pharmaceuticals 346
Large-scale testing (Phase 3)Study completedNCT00409175
What this trial is testing

Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis

Who this might be right for
Familial Amyloid Polyneuropathy
Pfizer 128
Not applicableLooking for participantsNCT06465810
What this trial is testing

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Who this might be right for
Transthyretin AmyloidosisATTR-CMATTRv-PN+3 more
AstraZeneca 1,850
Not applicableApproved For MarketingNCT02939820
What this trial is testing

Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

Who this might be right for
TTR-mediated AmyloidosisAmyloidosis, HereditaryAmyloid Neuropathies, Familial+3 more
Alnylam Pharmaceuticals
Large-scale testing (Phase 3)Looking for participantsNCT06672237
What this trial is testing

NTLA-2001 in ATTRv-PN

Who this might be right for
Neuromuscular DiseaseNeuromuscular Diseases (NMD)Neurodegenerative Disease+17 more
Intellia Therapeutics 60
Early research (Phase 1)Study completedNCT04601051
What this trial is testing

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Not applicableStudy completedNCT06414746
What this trial is testing

Hereditary Transthyretin Amyloidosis Polyneuropathy in Patients With Carpal Tunnel Syndrome in Russia

Who this might be right for
Hereditary Transthyretin AmyloidosisCarpal Tunnel SyndromePolyneuropathy+1 more
AstraZeneca 721
Not applicableNot Yet RecruitingNCT07654855
What this trial is testing

Long-term Safety of Eplontersen Treated aTTR Patients and in Liver Transplant and Severely Hepatic Impaired Subpopulations

Who this might be right for
Transthyretin AmyloidosisTransthyretin Amyloidosis With CardiomyopathyTransthyretin Amyloidosis With Polyneuropathy
AstraZeneca 320
Large-scale testing (Phase 3)Study completedNCT02175004
What this trial is testing

Extension Study Assessing Long Term Safety and Efficacy of IONIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP)

Who this might be right for
FAPFamilial Amyloid PolyneuropathyTTR+2 more
Ionis Pharmaceuticals, Inc. 135
Not applicableActive Not RecruitingNCT05873868
What this trial is testing

Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran

Who this might be right for
Transthyretin AmyloidosisAmyloidosis, Hereditary
Rennes University Hospital 20
Not applicableLooking for participantsNCT04561518
What this trial is testing

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

Who this might be right for
Transthyretin-Mediated AmyloidosisATTR Amyloidosis
Alnylam Pharmaceuticals 1,500
Not applicableStudy completedNCT01604122
What this trial is testing

Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers

Who this might be right for
Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP)Transthyretin Cardiomyopathy (TTR-CM)Familial Amyloid Cardiomyopathy+1 more
Pfizer 1
Not applicableLooking for participantsNCT05697861
What this trial is testing

Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Large-scale testing (Phase 3)Active Not RecruitingNCT05071300
What this trial is testing

Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

Who this might be right for
Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Ionis Pharmaceuticals, Inc. 151
Post-approval studies (Phase 4)Looking for participantsNCT06940336
What this trial is testing

To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adult Patients With Transthyretin Amyloid Polyneuropathy

Who this might be right for
Transthyretin Amyloid Polyneuropathy
Qilu Pharmaceutical Co., Ltd. 15
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