Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Uncontrolled Moderate to Severe”

35 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 35 results

Testing effectiveness (Phase 2)Looking for participantsNCT07219173
What this trial is testing

Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

Who this might be right for
Asthma
Eli Lilly and Company 531
Testing effectiveness (Phase 2)Active Not RecruitingNCT07120503
What this trial is testing

Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults With Moderate or Severe Asthma

Who this might be right for
Asthma (Diagnosis)
Windward Bio 136
Large-scale testing (Phase 3)Looking for participantsNCT05732727
What this trial is testing

Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease

Who this might be right for
Chronic Kidney Disease(CKD)Uncontrolled Hypertension
University Hospital, Tours 720
Testing effectiveness (Phase 2)Study completedNCT05251259
What this trial is testing

Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma

Who this might be right for
Asthma
AstraZeneca 670
Large-scale testing (Phase 3)Study completedNCT05280418
What this trial is testing

Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma

Who this might be right for
Asthma
McMaster University 27
Testing effectiveness (Phase 2)Study completedNCT01312961
What this trial is testing

Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma

Who this might be right for
Asthma
Sanofi 104
Not applicableStudy completedNCT00937066
What this trial is testing

Cost-effectiveness Study of Symbicort as Maintenance and Reliever Therapy (SMART)

Who this might be right for
Asthma
AstraZeneca 1,000
Post-approval studies (Phase 4)UnknownNCT02087696
What this trial is testing

Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis

Who this might be right for
Arthritis, Rheumatoid
Spanish Foundation of Rheumatology 122
Large-scale testing (Phase 3)Looking for participantsNCT06959095
What this trial is testing

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)

Who this might be right for
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline 981
Large-scale testing (Phase 3)Study completedNCT03428100
What this trial is testing

A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable

Who this might be right for
Atopic Dermatitis
Eli Lilly and Company 463
Testing effectiveness (Phase 2)Ended earlyNCT01673672
What this trial is testing

CYT003-QbG10, a TLR9-agonist, for Treatment of Uncontrolled Moderate to Severe Allergic Asthma

Who this might be right for
Moderate to Severe Allergic Asthma
Cytos Biotechnology AG 365
Not applicableStudy completedNCT01383564
What this trial is testing

Continuous Positive Airway Pressure Use in Asthma With Moderate to Severe Obstructive Sleep Apnea Patients

Who this might be right for
OSA
Chinese University of Hong Kong 101
Post-approval studies (Phase 4)Active Not RecruitingNCT05097287
What this trial is testing

Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma

Who this might be right for
Asthma
Sanofi 1,339
Testing effectiveness (Phase 2)Study completedNCT01854047
What this trial is testing

An Evaluation of Dupilumab in Patients With Moderate to Severe Uncontrolled Asthma

Who this might be right for
Asthma
Sanofi 776
Testing effectiveness (Phase 2)Study completedNCT00873860
What this trial is testing

Study to Evaluate the Safety and Efficacy of CAT-354

Who this might be right for
Asthma
MedImmune LLC 357
Large-scale testing (Phase 3)Study completedNCT03158311
What this trial is testing

Study to Compare QVM149 and Free Triple Combination of Salmeterol/Fluticasone + Tiotropium

Who this might be right for
Asthma
Novartis Pharmaceuticals 1,426
Large-scale testing (Phase 3)Ended earlyNCT04968184
What this trial is testing

Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD)

Who this might be right for
Chronic Kidney Diseases
KBP Biosciences 652
Large-scale testing (Phase 3)Looking for participantsNCT06961214
What this trial is testing

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

Who this might be right for
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline 960
Testing effectiveness (Phase 2)Study completedNCT06020014
What this trial is testing

Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA

Who this might be right for
Asthma
AstraZeneca 339
Testing effectiveness (Phase 2)Study completedNCT04570657
What this trial is testing

Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma

Who this might be right for
Asthma
AstraZeneca 250
Next Page