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Results for “pMMR/MSS Advanced Colorectal Cancer”

54 trials

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Showing 20 of 54 results

Large-scale testing (Phase 3)Looking for participantsNCT06791512
What this trial is testing

MFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC

Who this might be right for
Colorectal Cancer (CRC)pMMR/MSS Adenocarcinoma of the Colon or Rectum
Jun Huang 166
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06014944
What this trial is testing

Short-course Radiotherapy Combined With Furoquintinib and PD-1 Monoclonal Antibody

Who this might be right for
Rectal Cancer
Changhai Hospital 30
Testing effectiveness (Phase 2)UnknownNCT04724239
What this trial is testing

Sintilimab and Chidamide in Combination With or Without IBI305 in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma

Who this might be right for
Advanced Microsatellite Stable Colorectal CancerMetastatic Microsatellite-stable Colorectal Cancer
Sun Yat-sen University 48
Testing effectiveness (Phase 2)Looking for participantsNCT05731726
What this trial is testing

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Who this might be right for
pMMRMSSMSI-L+1 more
Zhejiang University 50
Early research (Phase 1)Looking for participantsNCT07510308
What this trial is testing

Clinical Study of MSH2-/- Tumor Cell Vaccines for Advanced pMMR Colorectal Cancer Patients

Who this might be right for
pMMR/MSS Advanced Colorectal Cancer
West China Hospital 9
Testing effectiveness (Phase 2)Looking for participantsNCT07448142
What this trial is testing

Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer

Who this might be right for
Colorectal Cancer (CRC)
Sun Yat-sen University 50
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07394192
What this trial is testing

Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS Stage II-III Rectal Cancer

Who this might be right for
Rectal CancerRadiotherapyPD-1 Inhibitor
Peking University Cancer Hospital & Institute 44
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07527520
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial

Who this might be right for
Rectal CancerModerately Hypofractionated RadiotherapySerplulimab+1 more
Fudan University 165
Testing effectiveness (Phase 2)Looking for participantsNCT06930118
What this trial is testing

The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines.

Who this might be right for
Advanced Colorectal Cancer in the Third-line Treatment and BeyondpMMR/MSS Advanced Colorectal Cancer
Shanghai Changzheng Hospital 60
Testing effectiveness (Phase 2)Looking for participantsNCT06543836
What this trial is testing

CtDNA-guided Treatment of TKI Plus PD-1 Inhibitor for Advanced pMMR/MSS Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 68
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07007767
What this trial is testing

Exploring Sintilimab + Bevacizumab + Decitabine for Advanced pMMR/MSS Colorectal Cancer (After 2+ Prior Therapies）

Who this might be right for
Colorectal Cancer Metastatic
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 32
Testing effectiveness (Phase 2)WithdrawnNCT05582031
What this trial is testing

Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers

Who this might be right for
Anal Squamous Cell CarcinomaColorectal NeoplasmsSoft Tissue Sarcoma+5 more
Translational Research in Oncology
Testing effectiveness (Phase 2)Looking for participantsNCT06911684
What this trial is testing

Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.

Who this might be right for
Rectal Cancer Patients
Sun Yat-sen University 88
Testing effectiveness (Phase 2)Active Not RecruitingNCT04833387
What this trial is testing

PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer

Who this might be right for
Colorectal Carcinoma
Sun Yat-sen University 30
Testing effectiveness (Phase 2)Looking for participantsNCT06709885
What this trial is testing

HDAC Inhibitor Combination With Chemoimmunotherapy in the Neoadjuvant Treatment of pMMR Locally Advanced Colon Cancer

Who this might be right for
Colon Adenocarcinoma
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 100
Testing effectiveness (Phase 2)Looking for participantsNCT07279077
What this trial is testing

Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial

Who this might be right for
Colon CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 38
Large-scale testing (Phase 3)Not Yet RecruitingNCT06443671
What this trial is testing

Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Peking University Cancer Hospital & Institute 132
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06599827
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC

Who this might be right for
Rectal Cancer
Shanghai Zhongshan Hospital 54
Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Large-scale testing (Phase 3)Looking for participantsNCT05768503
What this trial is testing

Comparing Chidamide+Sintilimab+Bev With Standard Second-line FOLFIRI+Bev in Advanced MSS/pMMR mCRC

Who this might be right for
Metastatic Microsatellite-stable Colorectal Cancer
Sun Yat-sen University 176
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