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Results for “pMMR/MSS Advanced Colorectal Cancer”

62 trials

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Showing 20 of 62 results

Testing effectiveness (Phase 2)WithdrawnNCT05582031
What this trial is testing

Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers

Who this might be right for
Anal Squamous Cell CarcinomaColorectal NeoplasmsSoft Tissue Sarcoma+5 more
Translational Research in Oncology
Testing effectiveness (Phase 2)UnknownNCT06239870
What this trial is testing

Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer

Who this might be right for
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Yunnan Cancer Hospital 35
Testing effectiveness (Phase 2)Looking for participantsNCT05731726
What this trial is testing

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Who this might be right for
pMMRMSSMSI-L+1 more
Zhejiang University 50
Large-scale testing (Phase 3)Looking for participantsNCT07528209
What this trial is testing

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

Who this might be right for
Rectal CancerpMMR (Microsatellite Stable Rectal Cancer)
Sun Yat-sen University 556
Testing effectiveness (Phase 2)Ended earlyNCT05733611
What this trial is testing

RP2/RP3 in Combination With Atezolizumab and Bevacizumab for the Treatment of Patients With CRC

Who this might be right for
Refractory Metastatic Colorectal CancerpMMRMSS
Replimune, Inc. 5
Not applicableActive Not RecruitingNCT06865521
What this trial is testing

Akkermansia Probiotics Plus Anti-PD-1 Monoclonal Antibody in MSS/pMMR Advanced Colorectal Cancer

Who this might be right for
Colo-rectal CancerPD-1 InhibitorAkkermansia Muciniphila
West China Hospital 22
Testing effectiveness (Phase 2)Looking for participantsNCT06764680
What this trial is testing

Oral Chemotherapy, Targeted Therapy and Immunotherapy With/Without Radiotherapy as 3rd- or Later-line Therapy for Advanced MSS/pMMR Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticChemotherapyTargeted Therapy+2 more
Sun Yat-sen University 57
Testing effectiveness (Phase 2)Looking for participantsNCT07070518
What this trial is testing

Study of GV20-0251 in Participants With Solid Tumor Malignancies

Who this might be right for
Solid Tumor CancerAdult Refractory CancerEndometrial Carcinoma (EC)+6 more
GV20 Therapeutics 350
Testing effectiveness (Phase 2)Looking for participantsNCT05669430
What this trial is testing

GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

Who this might be right for
Solid Tumor, AdultRefractory CancerEndometrial Carcinoma (EC)+4 more
GV20 Therapeutics 365
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07007767
What this trial is testing

Exploring Sintilimab + Bevacizumab + Decitabine for Advanced pMMR/MSS Colorectal Cancer (After 2+ Prior Therapies）

Who this might be right for
Colorectal Cancer Metastatic
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 32
Early research (Phase 1)Not Yet RecruitingNCT07411781
What this trial is testing

PIN in Combination With Sintilimab in Previously Treated pMMR/MSS CRC With Hepatic Metastases

Who this might be right for
Colorectal CancerAdult
Chinese PLA General Hospital 25
Large-scale testing (Phase 3)Looking for participantsNCT06791512
What this trial is testing

MFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC

Who this might be right for
Colorectal Cancer (CRC)pMMR/MSS Adenocarcinoma of the Colon or Rectum
Jun Huang 166
Testing effectiveness (Phase 2)Study completedNCT04895137
What this trial is testing

MFOLFOX6+Bevacizumab+PD-1 Monoclonal Antibody in Local Advanced MSS CRC

Who this might be right for
Colorectal CancerImmunotherapy
Sixth Affiliated Hospital, Sun Yat-sen University 42
Testing effectiveness (Phase 2)Looking for participantsNCT06484153
What this trial is testing

Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma

Who this might be right for
To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal CarcinomaTo Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal CancerCombination of Fruquintinib and Anti-PD-1 Antibody Was Reported to Improve Patient Prognosis in Colorectal Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Testing effectiveness (Phase 2)Active Not RecruitingNCT04833387
What this trial is testing

PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer

Who this might be right for
Colorectal Carcinoma
Sun Yat-sen University 30
Testing effectiveness (Phase 2)Looking for participantsNCT06930118
What this trial is testing

The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines.

Who this might be right for
Advanced Colorectal Cancer in the Third-line Treatment and BeyondpMMR/MSS Advanced Colorectal Cancer
Shanghai Changzheng Hospital 60
Testing effectiveness (Phase 2)Study completedNCT06884670
What this trial is testing

Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study

Who this might be right for
Rectal Cancer
The First Affiliated Hospital with Nanjing Medical University 130
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07656766
What this trial is testing

Sintilimab Plus Gossypol Acetate in Advanced Colorectal Cancer

Who this might be right for
Advanced Colorectal Cancer
Peking University People's Hospital 32
Testing effectiveness (Phase 2)Looking for participantsNCT07468630
What this trial is testing

Tolecizumab Plus Chemoimmunotherapy for pMMR/MSS Locally Advanced Colon Adenocarcinoma

Who this might be right for
Colon Adenocarcinoma
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 106
Not applicableLooking for participantsNCT07105631
What this trial is testing

Patient-reported Outcomes (PRO) and Treatment Outcomes of Chinese Patients With MSS-type Advanced Colorectal Cancer Who Received the Zidovudine Combination Regimen in the Real World

Who this might be right for
Colorectal Cancer
West China Hospital 300
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