Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “De-escalation Therapy”

145 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 145 results

Post-approval studies (Phase 4)Looking for participantsNCT06821191
What this trial is testing

Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study

Who this might be right for
Coronary Artery Disease
University of Florida 78
Testing effectiveness (Phase 2)Ended earlyNCT02842580
What this trial is testing

De-escalation Chemotherapies Versus Escalation in Non Pre-treated Unresectable Patients With Metastatic Colorectal Cancer

Who this might be right for
Colorectal Neoplasms
Federation Francophone de Cancerologie Digestive 21
Testing effectiveness (Phase 2)Ended earlyNCT06365437
What this trial is testing

A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation

Who this might be right for
Kidney Transplantation
ITB-Med LLC 33
Not applicableStudy completedNCT03395951
What this trial is testing

Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients

Who this might be right for
SepsisHeart FailureHeart Diseases+3 more
Catharina Ziekenhuis Eindhoven 18
Large-scale testing (Phase 3)Looking for participantsNCT07189325
What this trial is testing

A Prospective Randomized Non-inferiority Trial Comparing Anti-CD20 Maintenance Versus De-Escalation Strategy In Relapsing-Remitting Multiple Sclerosis

Who this might be right for
Relapsing-Remitting Multiple Sclerosis (RRMS)Anti-CD20 Therapy
University Hospital, Montpellier 250
Testing effectiveness (Phase 2)Study completedNCT03944915
What this trial is testing

De-Escalation Therapy for Human Papillomavirus Negative Disease

Who this might be right for
Human Papilloma VirusSquamous Cell CarcinomaSquamous Cell Carcinoma of the Head and Neck+2 more
University of Chicago 35
Testing effectiveness (Phase 2)Looking for participantsNCT05297617
What this trial is testing

Deescalation of Endocrine Therapy Duration in Women With HR+ HER2- Breast Cancer at Very Low Risk

Who this might be right for
Breast Cancer
UNICANCER 696
Large-scale testing (Phase 3)Looking for participantsNCT06675214
What this trial is testing

Under Whole-course of Immunotherapy, Gradient Fractionated RT with CCT Versus CFRT with CCT for LANPC Who Achieved PR Post Induction Chemotherapy.

Who this might be right for
Nasopharyngeal CarcinomaDe-escalation Therapy
Sun Yat-sen University 586
Testing effectiveness (Phase 2)Looking for participantsNCT07661927
What this trial is testing

Skipping Hormone Therapy in Low-Risk Early Breast Cancer

Who this might be right for
Breast Cancer (Early Breast Cancer)
UNICANCER 700
Not applicableStudy completedNCT04393233
What this trial is testing

Drug Management of Rheumatoid Arthritis in Covid-19 Context : Impact on Therapeutic De-escalation

Who this might be right for
Rheumatoid ArthritisCOVID
University Hospital, Brest 300
Testing effectiveness (Phase 2)Looking for participantsNCT05410730
What this trial is testing

SHR-1501 Alone or in Combination With BCG or SHR-1316 in Subjects With NMIBC

Who this might be right for
High-risk NMIBC
Shanghai Hengrui Pharmaceutical Co., Ltd. 150
Testing effectiveness (Phase 2)Looking for participantsNCT07183319
What this trial is testing

Circulating Tumor DNA Response In Urothelial Cancer

Who this might be right for
Urothelial Carcinoma
University of Oklahoma 30
Not applicableLooking for participantsNCT07466238
What this trial is testing

HAIC Plus Systemic Therapy as De-escalation Therapy Strategy for Biliary Tract Cancer

Who this might be right for
Biliary Tract Cancer (BTC)
Peking University 40
Testing effectiveness (Phase 2)WithdrawnNCT04159493
What this trial is testing

Controlled Phase 2 Study to Determine Lowest Efficacious Dose of Ovestin in Vulvar and Vaginal Atrophy

Who this might be right for
Vaginal Atrophy
Aspen USA Inc
Not applicableLooking for participantsNCT06238297
What this trial is testing

Rapid De-escalation of Anti-MRSA Therapy Guided by S. Aureus Nares Screening in Case of Pneumonia

Who this might be right for
Pneumonia, Bacterial
University of Bari Aldo Moro 76
Not applicableNot Yet RecruitingNCT07374718
What this trial is testing

Safety and Efficacy of De-escalation Dual Antiplatelet Therapy After BioFreedom™ Stenting in ACS Patients With Moderate-to-high Ischemic and High Bleeding Risk

Who this might be right for
Acute Coronary Syndrome (ACS)High Bleeding Risk(HBR)Coronary Artery Disease (CAD)
Shenyang Northern Hospital 468
Early research (Phase 1)Study completedNCT00002890
What this trial is testing

Monoclonal Antibody Therapy in Treating Patients With Myelodysplastic Syndrome or Relapsed or Refractory Acute Myeloid Leukemia or Chronic Myelogenous Leukemia

Who this might be right for
LeukemiaMyelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center 24
Post-approval studies (Phase 4)Looking for participantsNCT07303686
What this trial is testing

De-escalation of Ustekinumab Therapy in Patients With Crohn's Disease and Ulcerative Colitis

Who this might be right for
Crohn Disease (CD)Ulcerative Colitis (UC)
McGill University Health Centre/Research Institute of the McGill University Health Centre 115
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07428018
What this trial is testing

Pragmatic Study to Optimize Neoadjuvant Treatment and Surgical De-escalation in HR+/HER2- Early Breast Cancer Using Oncotype DX and Abemaciclib

Who this might be right for
Breast CancerHER2 + Breast CancerHR Positive+1 more
Mario Negri Institute for Pharmacological Research 150
Not applicableNot Yet RecruitingNCT07724769
What this trial is testing

De-escalation of RNI in Breast Cancer Patients With pN0 After Neoadjuvant Therapy

Who this might be right for
Breast Cancer
Aya Ahmed Sayed 100
Next Page