Early research (Phase 1)Ended earlyNCT01420952What this trial is testingImaging of Brain Receptors Using (11C)mGlu1Who this might be right forDosimetryPharmacokinetics National Institute of Mental Health (NIMH) 3
Early research (Phase 1)Study completedNCT00538798What this trial is testingPET Imaging of Brain mGluR5 Receptors Using [18F]SP203Who this might be right forHealthyGlutamate ReceptormGlur5 Protein+3 more National Institute of Mental Health (NIMH) 50
Early research (Phase 1)Study completedNCT01548703What this trial is testingA Multiple Ascending Dose Study of BCI-838 in Healthy VolunteersWho this might be right forHealthy BrainCells Inc. 30
Early research (Phase 1)Study completedNCT01551329What this trial is testingKetamine for Depression and Alcohol DependenceWho this might be right forDepressionAlcohol Dependence Yale University 5
Not applicableActive Not RecruitingNCT03655223What this trial is testingEarly Check: Expanded Screening in NewbornsWho this might be right forSpinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more RTI International 30,000
Early research (Phase 1)Study completedNCT01896843What this trial is testingEvaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in BrainWho this might be right formGluR5 Receptors National Institute of Mental Health (NIMH) 19
Post-approval studies (Phase 4)WithdrawnNCT02028026What this trial is testingThe Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar DepressivesWho this might be right forMajor Depressive DisorderAnxietyComorbidity Massachusetts General Hospital
Testing effectiveness (Phase 2)Study completedNCT03051256What this trial is testingSafety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDDWho this might be right forDepressive Disorder, MajorDepressive Disorder, Treatment-Resistant Relmada Therapeutics, Inc. 62
Post-approval studies (Phase 4)Study completedNCT00688324What this trial is testingBiomarker Study of Acamprosate in SchizophreniaWho this might be right forSchizophreniaSchizoaffective Disorder University of Maryland, Baltimore 36
Large-scale testing (Phase 3)UnknownNCT00069550What this trial is testingIndependent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett SyndromeWho this might be right forRett Syndrome Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 90
Not applicableStudy completedNCT02456168What this trial is testingDevelopment of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus ErythematosusWho this might be right forSystemic Lupus Erythematosus Northwell Health 30
Early research (Phase 1)Study completedNCT02286817What this trial is testingPhase I Single Dose, Open-Label Pharmacokinetic Study and Single-Blind, Placebo-Controlled Dose Escalation Study of NFC-1 in Adolescents With Attention-Deficit Hyperactivity DisorderWho this might be right forAttention-deficit Hyperactivity Disorder (ADHD) Aevi Genomic Medicine, LLC, a Cerecor company 30
Not applicableStudy completedNCT00980408What this trial is testingThe Influence of Glutamate on Memory in HumansWho this might be right forHealthy Individuals University Hospital, Bonn 120
Post-approval studies (Phase 4)Looking for participantsNCT07076342What this trial is testingThe Role of mGluR5 in CBT-IWho this might be right forMajor Depressive Disorder (MDD) Stony Brook University 42
Large-scale testing (Phase 3)Study completedNCT02777931What this trial is testingEfficacy and Safety of NFC-1 in Adolescents With Genetic Disorders Impacting mGluR and ADHDWho this might be right forAttention Deficit Disorder With Hyperactivity Aevi Genomic Medicine, LLC, a Cerecor company 101
Large-scale testing (Phase 3)Looking for participantsNCT07766655What this trial is testingStudying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)Who this might be right forSmoking Cessation Axsome Therapeutics, Inc. 705
Not applicableUnknownNCT02512146What this trial is testingThe Expression of the Ionotropic Glutamate Receptors in Colon of IBSWho this might be right forIrritable Bowel Syndrome Shandong University 80
Not applicableStudy completedNCT01304147What this trial is testingIntranasal Ketamine in Treatment-Resistant DepressionWho this might be right forMajor Depressive Disorder James Murrough 20
Not applicableEnded earlyNCT00951314What this trial is testingBrain Glutamate Receptors and Cocaine DependenceWho this might be right forDrug AbuseCocaine Dependence National Institute on Drug Abuse (NIDA) 30
Early research (Phase 1)Study completedNCT01359852What this trial is testing[11C]JNJ-42491293, a Possible PET Ligand for the mGlu2 Receptor, in Healthy Adult VolunteersWho this might be right forHealthy Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 20