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Results for “Hedgehog Pathway”

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Showing 17 of 0 results

Testing effectiveness (Phase 2)Study completedNCT01195415
What this trial is testing

Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer

Who this might be right for
Recurrent Pancreatic CarcinomaStage IV Pancreatic Cancer
National Cancer Institute (NCI) 25
Testing effectiveness (Phase 2)Study completedNCT03132636
What this trial is testing

PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy

Who this might be right for
Carcinoma, Basal Cell
Regeneron Pharmaceuticals 138
Testing effectiveness (Phase 2)Looking for participantsNCT05561634
What this trial is testing

Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma

Who this might be right for
Basal Cell CarcinomaRadiotherapy; Complications
University Hospital, Lille 82
Testing effectiveness (Phase 2)Study completedNCT01125800
What this trial is testing

A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB

Who this might be right for
MedulloblastomaRhabdomyosarcomaNeuroblastoma+3 more
Novartis Pharmaceuticals 76
Early research (Phase 1)Study completedNCT00670189
What this trial is testing

BMS-833923 (XL139) in Subjects With Advanced or Metastatic Cancer

Who this might be right for
Hedgehog PathwaySmoothenedBasal Cell Carcinoma (BCC)+1 more
Bristol-Myers Squibb 53
Testing effectiveness (Phase 2)Active Not RecruitingNCT06422884
What this trial is testing

Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)

Who this might be right for
Idiopathic Pulmonary FibrosisProgressive Fibrosing Interstitial Lung Disease
Endeavor Biomedicines, Inc. 213
Testing effectiveness (Phase 2)Study completedNCT01787552
What this trial is testing

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Who this might be right for
Primary MyelofibrosisThrombocytosisEssential Thrombocythemia+7 more
Novartis Pharmaceuticals 50
Very early researchUnknownNCT02749513
What this trial is testing

Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients

Who this might be right for
Esophageal Cancer
Dallas VA Medical Center 18
Testing effectiveness (Phase 2)Study completedNCT00959647
What this trial is testing

Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study

Who this might be right for
Ovarian CancerBasal Cell CarcinomaMetastatic Colorectal Cancer
Genentech, Inc. 19
Not applicableUnknownNCT01731262
What this trial is testing

Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis

Who this might be right for
Arthritis, RheumatoidNeovascularization, PathologicSynovitis
Third Affiliated Hospital, Sun Yat-Sen University 78
Early research (Phase 1)Study completedNCT01576666
What this trial is testing

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Who this might be right for
Dose EscalationSafetyPreliminary Efficacy+9 more
Novartis Pharmaceuticals 120
Testing effectiveness (Phase 2)Study completedNCT00957229
What this trial is testing

To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS)

Who this might be right for
Basal Cell Nevus SyndromeGorlin Syndrome
UCSF Benioff Children's Hospital Oakland 41
Early research (Phase 1)Study completedNCT01769768
What this trial is testing

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Who this might be right for
Advanced Solid Tumor
Novartis Pharmaceuticals 114
Testing effectiveness (Phase 2)UnknownNCT04481100
What this trial is testing

CCRT With Itraconazole in Locally Advanced Squamous Esophageal Cancer

Who this might be right for
Esophageal NeoplasmEsophageal DiseasesEsophageal Squamous Cell Carcinoma
Hangzhou Cancer Hospital 38
Very early researchStudy completedNCT02357836
What this trial is testing

Neoadjuvant Itraconazole in Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
University of Texas Southwestern Medical Center 13
Early research (Phase 1)Study completedNCT00991718
What this trial is testing

The Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential

Who this might be right for
Healthy
Genentech, Inc. 24
Early research (Phase 1)Study completedNCT00607724
What this trial is testing

GDC-0449 in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
Genentech, Inc. 68